公开(公告)号：ES2473620T3

公开(公告)日：2014-07-07

申请号：ES08704452

申请日：2008-02-05

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： TOKUMOTO SEIJI ,  MATSUDO TOSHIYUKI ,  KUWAHARA TETSUJI

IPC: A61M37/00

Abstract: Un dispositivo (1) de microagujas para el diagnóstico de una alergia, que comprende: un sustrato (2), microagujas (3) formadas sobre el sustrato (2) a una densidad de 100 a 10.000 agujas por 1 cm2, que pueden perforar la piel hasta una profundidad de entre 5 50 μm y 500 μm, y medio de retención de alérgenos colocados en las microagujas (3), que retienen al menos un alérgeno, en el que las microagujas (3) se preparan usando un material de resina no metálico, natural o sintético.

公开(公告)号：SG183421A1

公开(公告)日：2012-09-27

申请号：SG2012061743

申请日：2011-02-24

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MATSUDO TOSHIYUKI ,  NISHIMURA SHINPEI ,  TOKUMOTO SEIJI ,  MORIMOTO KUMI

Abstract: MICRO-NEEDLE DEVICE AND PREPARATION METHODThe present invention provides a micro-needle device that includes a substrate, a micro-needle provided on the substrate, and a physiologically active composition deposited on the micro-needle5 and/or the substrate. In the micro-needle device, the physiologically active composition contains: at least one polyhydric alcohol selected from glycerin, ethylene glycol, propylene glycol and 1,3-butylene glycol; and a physiologically active substance, and contains substantially no water.Figure 1

公开(公告)号：CA2790923C

公开(公告)日：2017-10-31

申请号：CA2790923

申请日：2011-02-24

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MATSUDO TOSHIYUKI ,  NISHIMURA SHINPEI ,  TOKUMOTO SEIJI ,  MORIMOTO KUMI

IPC: A61M37/00

Abstract: A micro-needle device has a base, micro-needles, which are established on this base, and a physiologically active composition, which is adhered to the micro-needles and/or the base. The physiologically active composition contains a physiologically active substance and at least one type of polyhydric alcohol, selected from glycerin, ethylene glycol, propylene glycol and 1, 3-butylene glycol. The micro-needle device is effectively free of water.

公开(公告)号：AT532553T

公开(公告)日：2011-11-15

申请号：AT07713903

申请日：2007-02-07

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： TOKUMOTO SEIJI ,  MATSUDO TOSHIYUKI ,  KUWAHARA TETSUJI

IPC: A61M37/00 ,  A61M5/30 ,  A61N1/30

Abstract: It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).

公开(公告)号：MY158687A

公开(公告)日：2016-10-31

申请号：MYPI2012700570

申请日：2011-02-24

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： TOKUMOTO SEIJI ,  MORIMOTO KUMI ,  MATSUDO TOSHIYUKI ,  NISHIMURA SHINPEI

Abstract: The present invention provides a micro-needle device that includes a substrate, a micro-needle provided on the substrate, and a physiologically active composition deposited on the micro-needle and/or the substrate. In the micro-needle device, the physiologically active composition contains: at least one polyhydric alcohol selected from glycerin, ethylene glycol, propylene glycol and 1,3-butylene glycol; and a physiologically active substance, and contains substantially no water.

公开(公告)号：CA2790923A1

公开(公告)日：2011-09-01

申请号：CA2790923

申请日：2011-02-24

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MATSUDO TOSHIYUKI ,  NISHIMURA SHINPEI ,  TOKUMOTO SEIJI ,  MORIMOTO KUMI

IPC: A61M37/00

Abstract: A micro-needle device has a base, micro-needles, which are established on this base, and a physiologically active composition, which is adhered to the micro-needles and/or the base. The physiologically active composition contains a physiologically active substance and at least one type of polyhydric alcohol, selected from glycerin, ethylene glycol, propylene glycol and 1, 3-butylene glycol. The micro-needle device is effectively free of water.

公开(公告)号：SG173160A1

公开(公告)日：2011-08-29

申请号：SG2011054277

申请日：2010-01-25

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： KUWAHARA TETSUJI ,  TOKUMOTO SEIJI ,  MATSUDO TOSHIYUKI

Abstract: MICRONEEDLE DEVICEThe present invention aims to allow high molecular weight active ingredients to be contained in a coating agent substantially uniformly. For this purpose, a microneedle device 1 includes amicroneedle base 2, and microneedles 3 capable of piercing a skin and being disposed on the microneedle base 2, wherein at least a part of a surface of the microneedles 3 and/or the microneedle base 2 is coated with, a coating agent containing a high molecular weight active ingredient and a water-soluble polymer, and the content of thewater-soluble polymer in the coating agent is 0.1 to 30% by weight, and the ratio of the content of the water-soluble polymer to the content of the high molecular weight active ingredient in the coating agent is 5:1 to 1:100.Figure 1

公开(公告)号：EP2153863A4

公开(公告)日：2014-01-08

申请号：EP07830111

申请日：2007-10-18

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： TOKUMOTO SEIJI ,  MATSUDO TOSHIYUKI ,  KUWAHARA TETSUJI

IPC: A61M37/00 ,  A61K9/00 ,  A61L31/00 ,  B81C1/00

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00206

Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).

公开(公告)号：EP3006077A4

公开(公告)日：2017-05-24

申请号：EP14804072

申请日：2014-05-29

Applicant: HISAMITSU PHARMACEUTICAL CO INC

Inventor： HASHIMOTO EIJI ,  MATSUDO TOSHIYUKI ,  NISHIMURA SHINPEI ,  TOKUMOTO SEIJI

IPC: A61M37/00 ,  B05D3/04 ,  B81C1/00

CPC classification number: B05C15/00 ,  A61M37/0015 ,  A61M2037/0053 ,  B05C3/00 ,  B05C21/00 ,  B05D3/0486 ,  B81B2201/055 ,  B81C99/0025 ,  F24F3/14 ,  F24F3/1603

Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

Abstract translation: 本发明提供一种用于制造治疗用微针的系统，所述系统用于通过用包含药物的涂布液涂布微针来调节用于制造治疗用微针的涂布室内的空气环境，所述用于制造治疗用微针的系统包括空气压缩机， 湿度调节器，其构造成调节从空气压缩机供应的空气的湿度;以及空气过滤器，其构造成从空气中消除将被供应到涂布室内部的微生物。

公开(公告)号：EP2119469A4

公开(公告)日：2011-06-22

申请号：EP08704452

申请日：2008-02-05

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： TOKUMOTO SEIJI ,  MATSUDO TOSHIYUKI ,  KUWAHARA TETSUJI

IPC: A61M37/00

CPC classification number: A61B10/0035 ,  A61M37/0015 ,  A61M2037/0046