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公开(公告)号：IE63500B1
公开(公告)日：1995-05-03
申请号：IE304389
申请日：1989-09-22
Applicant: HOECHST AG
Inventor： KESSELER KURT , BARTMANN WILHELM , WESS GUENTHER , GRANZER ERNOLD
IPC: A61K31/215 , A61K31/34 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/496 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C33/48 , C07C45/30 , C07C47/222 , C07C47/24 , C07C51/367 , C07C59/42 , C07C59/46 , C07C59/48 , C07C59/56 , C07C59/76 , C07C67/31 , C07C69/606 , C07C69/732 , C07C69/734 , C07D207/08 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/48 , C07D213/55 , C07D213/62 , C07D213/63 , C07D231/12 , C07D233/64 , C07D237/08 , C07D239/26 , C07D261/08 , C07D275/02 , C07D309/30 , C07D405/06
Abstract: 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I I as well as the corresponding lactones of the formula II II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
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公开(公告)号：NO175637C
公开(公告)日：1994-11-09
申请号：NO893167
申请日：1989-08-04
Applicant: HOECHST AG
Inventor： BECK GERHARD , BARTMANN WILHELM , WESS GUNTHER , GRANZER ERNOLD
IPC: A61K31/19 , A61K31/215 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C29/147 , C07C33/48 , C07C45/56 , C07C47/55 , C07C59/56 , C07C67/00 , C07C67/31 , C07C67/343 , C07C69/65 , C07C69/732 , C07C69/738 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D213/79 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06
Abstract: 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II in which R1 and R2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
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公开(公告)号：DE58907280D1
公开(公告)日：1994-04-28
申请号：DE58907280
申请日：1989-09-19
Applicant: HOECHST AG
Inventor： KESSELER KURT , BARTMANN WILHELM , WESS GUENTHER , GRANZER ERNOLD
IPC: A61K31/215 , A61K31/34 , A61K31/35 , A61K31/351 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/496 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C33/48 , C07C45/30 , C07C47/222 , C07C47/24 , C07C51/367 , C07C59/42 , C07C59/46 , C07C59/48 , C07C59/56 , C07C59/76 , C07C67/31 , C07C69/606 , C07C69/732 , C07C69/734 , C07D207/08 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/48 , C07D213/55 , C07D213/62 , C07D213/63 , C07D231/12 , C07D233/64 , C07D237/08 , C07D239/26 , C07D261/08 , C07D275/02 , C07D309/30 , C07D405/06
Abstract: 7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I I as well as the corresponding lactones of the formula II II in which R and R DEG have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
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公开(公告)号：NO172538C
公开(公告)日：1993-08-04
申请号：NO891937
申请日：1989-05-12
Applicant: HOECHST AG
Inventor： JENDRALLA HEINER , WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD
IPC: A61K31/365 , A61K31/185 , A61K31/19 , A61K31/35 , A61K31/366 , A61P3/06 , C07C39/367 , C07C59/64 , C07C59/68 , C07C323/01 , C07C323/09 , C07D309/30
Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.
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公开(公告)号：NO172537B
公开(公告)日：1993-04-26
申请号：NO883074
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： BERGMANN ANDREAS , BARTMANN WILHELM , BECK GERHARD , LAU HANS-HERMANN
IPC: C07D213/30 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61P3/06 , A61P9/10 , C07C45/68 , C07C47/55 , C07C51/00 , C07C51/09 , C07C59/00 , C07C59/125 , C07C59/48 , C07C59/68 , C07C59/72 , C07C59/90 , C07C67/00 , C07C313/00 , C07C323/52 , C07C333/04 , C07D213/55 , C07D239/26 , C07D309/10 , C07D309/30 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D493/04 , C07D493/14 , C07F7/18 , C07H15/18
Abstract: 3-Desmethyl-4-fluoromevalonic acid derivatives of the formula I and the corresponding dihydroxycarboxylic acid derivatives of the formula II … … in which R, X and Y have the meanings given, processes for the preparation of these compounds, their use as medicaments and pharmaceutical preparations are described. Novel intermediates for the preparation of the compounds of the formula I or formula II are additionally described.
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Patent Agency Ranking
公开(公告)号：NO170803C
公开(公告)日：1992-12-09
申请号：NO883073
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： KESSELER KURT , BECK GERHARD , BARTMANN WILHELM , GRANZER ERNOLD
IPC: A61K31/44 , A61K31/365 , A61K31/4418 , A61K31/443 , A61K31/505 , A61P3/06 , A61P9/10 , C07D213/55 , C07D239/26 , C07D405/06 , C07D405/14 , C07F7/18 , C07D213/04 , C07D237/06
Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.
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公开(公告)号：HU206312B
公开(公告)日：1992-10-28
申请号：HU239489
申请日：1989-05-12
Applicant: HOECHST AG
Inventor： JENDRALLA HEINER , WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD
IPC: A61K31/365 , A61K31/185 , A61K31/19 , A61K31/35 , A61K31/366 , A61P3/06 , C07C39/367 , C07C59/64 , C07C59/68 , C07C323/01 , C07C323/09 , C07D309/30 , C07C59/48 , A61K31/075
Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.
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公开(公告)号：NZ230217A
公开(公告)日：1991-12-23
申请号：NZ23021789
申请日：1989-08-04
Applicant: HOECHST AG
Inventor： BECK GERHARD , BARTMANN WILHELM , WESS GUNTHER , GRANZER ERNOLD
IPC: A61K31/19 , A61K31/215 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C29/147 , C07C33/48 , C07C45/56 , C07C47/55 , C07C59/56 , C07C67/00 , C07C67/31 , C07C67/343 , C07C69/65 , C07C69/732 , C07C69/738 , C07D207/32 , C07D207/333 , C07D207/337 , C07D213/30 , C07D213/48 , C07D213/55 , C07D213/79 , C07D237/08 , C07D239/26 , C07D307/54 , C07D309/30 , C07D333/24 , C07D405/06 , C07D407/06 , C07D409/06 , C07D213/26 , C07D207/08 , C07C47/24 , C07D309/20 , A61K31/23
Abstract: 6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II in which R1 and R2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.
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公开(公告)号：NO167795C
公开(公告)日：1991-12-11
申请号：NO883071
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD , GRANZER ERNOLD
IPC: C12N9/99 , A61K31/19 , A61K31/22 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/381 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C31/125 , C07C31/13 , C07C31/135 , C07C31/137 , C07C33/025 , C07C33/12 , C07C33/14 , C07C33/28 , C07C33/38 , C07C33/46 , C07C33/48 , C07C41/00 , C07C43/13 , C07C43/178 , C07C47/00 , C07C47/21 , C07C51/00 , C07C51/09 , C07C59/42 , C07C59/48 , C07C59/54 , C07C59/56 , C07C59/58 , C07C59/64 , C07C67/00 , C07C69/65 , C07C69/66 , C07C69/675 , C07C69/732 , C07C69/738 , C07C253/00 , C07D307/34 , C07D307/54 , C07D309/30 , C07D333/02 , C07D333/38 , C07D405/06 , C07D407/02 , C07D407/06 , C07D409/02 , C07D409/06 , C07C59/245
Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).
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公开(公告)号：AU608868B2
公开(公告)日：1991-04-18
申请号：AU1929588
申请日：1988-07-22
Applicant: HOECHST AG
Inventor： WESS GUNTHER , BARTMANN WILHELM , BECK GERHARD , ANAGNOSTOPULOS HIRISTO
IPC: A61K31/38 , A61K31/085 , A61K31/10 , A61K31/12 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/34 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/00 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D317/38 , C07D333/16 , C07C149/273 , C07C147/14 , A61K31/185 , A61K31/255 , C07C147/10
Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases (I) in which R1, R2, R3, R4, R5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
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