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公开(公告)号：GR850718B
公开(公告)日：1985-07-19
申请号：GR850100718
申请日：1985-03-21
Applicant: HOECHST AG
Inventor： URBACH HANS JORG DR , HENNING RAINER DR , GEIGER ROLF PROF DR , TEETZ VOLKER DR
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公开(公告)号：GR76898B
公开(公告)日：1984-09-04
申请号：GR820169182
申请日：1982-09-01
Applicant: HOECHST AG
Inventor： HENNING RAINER DR , URBACH DRHANSJOTG , GEIGER ROLF PROF DR , TEETZ VOLKER DR , SCHOLKENS BERNWARD DR
IPC: C07C275/16 , C07C67/00 , C07C239/00 , C07C275/24 , C07C279/14 , C07C301/00 , C07C303/40 , C07C311/30 , C07C313/00 , C07C315/04 , C07C317/50 , C07C323/44 , C07C323/57 , C07C323/59 , C07D207/16 , C07D207/22 , C07D209/20 , C07D209/42 , C07D209/52 , C07D211/60 , C07D213/55 , C07D217/12 , C07D217/26 , C07D223/06 , C07D231/12 , C07D233/54 , C07D277/06 , C07D333/24 , C07D333/60 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/04 , C07D495/04
Abstract: Compounds of the formula I I in which n denotes 0-3, R1 and R1' are the same or different and denote hydrogen, alkyl or alkenyl, phenyl or benzyl, each substituted as desired; R2 denotes hydrogen, alkyl or alkenyl; R3 denotes hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl or aminoalkyl, alkanoylaminoalkyl, guanidinoalkyl, imidazolylalkyl, indolylalkyl, mercaptoalkyl or alkylthioalkyl, phenylalkyl, hydroxphenylalkyl, phenoxyalkyl or phenylthioalkyl, or R2 and R3, together with the C and N atoms carrying them, denote a saturated or unsaturated 4- to 8-membered monocyclic or 8- to 10-membered bicyclic isocycle or heterocycle, optionally monosubstituted or disubstituted by hydroxyl, alkoxy having 1 to 3 C atoms or alkyl, R4 denotes hydrogen, alkyl, alkenyl, alkadienyl, alkinyl, alkeninyl or alkadiinyl, cycloalkyl, phenyl, benzyl, phenethyl or phenylpropyl, each of which can be optionally monosubstituted or disubstituted; R5 denotes hydrogen or alkyl, hydroxyl or alkoxy and R6 denotes hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, optionally monosubstituted or disubstituted phenyl or naphthyl, their salts, a process for their preparation and their use as medicaments.
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公开(公告)号：DE3160852D1
公开(公告)日：1983-10-13
申请号：DE3160852
申请日：1981-08-26
Applicant: HOECHST AG
Inventor： GEIGER ROLF PROF DR
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公开(公告)号：DE3146598A1
公开(公告)日：1983-07-07
申请号：DE3146598
申请日：1981-11-25
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG DR , GEIGER ROLF PROF DR , OBERMEIER RAINER DR , MUELLNER HUBERT DR
IPC: A61K38/22 , A61K38/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07K7/06 , C07K14/66 , C07C103/52 , A61K37/02
Abstract: A peptide of the formula B1-B2-A1-A2-X in which B1 denotes a basic aminoacid, B2 denotes a basic aminoacid, A1 denotes an aromatic aminoacid, A2 denotes an aromatic aminoacid and X denotes an aminoacid in which the carboxyl group can be esterified, a process for the preparation thereof and the use thereof.
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公开(公告)号：DE3177311D1
公开(公告)日：1994-06-09
申请号：DE3177311
申请日：1981-08-22
Applicant: HOECHST AG
Inventor： GEIGER ROLF PROF DR , TEETZ VOLKER DR , URBACH HANSJOERG DR , SCHOELKENS BERNWARD DR , HENNING RAINER DR
IPC: C07D209/42 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61K38/00 , A61P9/12 , C07D217/26 , C07D233/64 , C07D241/20 , C07D307/54 , C07D309/10 , C07D317/66 , C07D333/24 , C07D335/02 , C07D339/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K14/81 , A61K37/64
Abstract: Amino acid derivatives of the formula I in which n, R , R and R have the meanings given, and salts thereof are used as medicaments.
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Patent Agency Ranking
公开(公告)号：DE3177130D1
公开(公告)日：1990-01-11
申请号：DE3177130
申请日：1981-08-22
Applicant: HOECHST AG
Inventor： GEIGER ROLF PROF DR , TEETZ VOLKER DR , URBACH HANSJOERG DR , SCHOELKENS BERNWARD DR , HENNING RAINER DR
IPC: C07D209/42 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61K38/00 , A61P9/12 , C07D217/26 , C07D233/64 , C07D241/20 , C07D307/54 , C07D309/10 , C07D317/66 , C07D333/24 , C07D335/02 , C07D339/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K14/81
Abstract: Amino acid derivatives of the formula I in which n, R , R and R have the meanings given, and salts thereof are used as medicaments.
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17.发明专利
公开(公告)号：AT48415T
公开(公告)日：1989-12-15
申请号：AT81106535
申请日：1981-08-22
Applicant: HOECHST AG
Inventor： GEIGER ROLF PROF DR , TEETZ VOLKER DR , URBACH HANSJOERG DR , SCHOELKENS BERNWARD DR , HENNING RAINER DR
IPC: A61K38/00 , C07K5/02 , C07D217/26 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12
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公开(公告)号：AT17584T
公开(公告)日：1986-02-15
申请号：AT82110742
申请日：1982-11-20
Applicant: HOECHST AG
Inventor： KOENIG WOLFGANG DR , GEIGER ROLF PROF DR , OBERMEIER RAINER DR , MUELLNER HUBERT DR
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19.发明专利
公开(公告)号：DE3361410D1
公开(公告)日：1986-01-16
申请号：DE3361410
申请日：1983-06-25
Applicant: HOECHST AG
Inventor： KONIG WOLFGANG DR , GEIGER ROLF PROF DR , OBERMEIER RAINER DR , MULLNER HUBERT DR
IPC: C07K14/52 , A61K38/00 , A61K38/21 , A61K39/39 , A61P35/00 , A61P37/00 , C07K7/06 , C07K14/555 , C07K14/565 , A61K37/02
Abstract: The invention provides a nonapeptide of the formula I Glu-Asp-Ser-Ser-Ser-Thr-Gly-Trp-Asn-OH (I) a process for the preparation thereof and its use, furthermore intermediates for preparing a compound of the formula I.
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公开(公告)号：DE3410732A1
公开(公告)日：1985-09-26
申请号：DE3410732
申请日：1984-03-23
Applicant: HOECHST AG
Inventor： URBACH HANSJOERG DR , HENNING RAINER DR , GEIGER ROLF PROF DR , TEETZ VOLKER DR
IPC: A61K38/00 , A61K38/55 , A61P27/02 , A61P27/06 , A61P43/00 , C07D209/12 , A61K31/395 , A61K31/40 , A61K31/44 , A61K31/47 , C07D217/22
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