公开(公告)号：NO128275B

公开(公告)日：1973-10-22

申请号：NO332668

申请日：1968-08-26

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W ,  FRANZMAIR R ,  SCHMIDT B

IPC: C07D27/14

公开(公告)号：ZA7203032B

公开(公告)日：1973-02-28

申请号：ZA7203032

申请日：1972-05-04

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  KLOETZER W ,  TEITEL S

IPC: C07D20060101 ,  C07D

公开(公告)号：SE340460B

公开(公告)日：1971-11-22

申请号：SE1698068

申请日：1968-12-11

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W

IPC: C07D51/44

公开(公告)号：SE310683B

公开(公告)日：1969-05-12

申请号：SE1052360

申请日：1960-11-02

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W

IPC: C07D51/44

公开(公告)号：NO129571B

公开(公告)日：1974-04-29

申请号：NO332768

申请日：1968-08-26

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W ,  FRANZMAIR R

IPC: C07D27/04

公开(公告)号：ZA723031B

公开(公告)日：1973-02-28

申请号：ZA723031

申请日：1972-05-04

Applicant: HOFFMANN LA ROCHE

Inventor： BROSSI A ,  KLOETZER W ,  TEITEL S

IPC: C07D20060101 ,  C07D

公开(公告)号：SE340620B

公开(公告)日：1971-11-29

申请号：SE1150468D

申请日：1968-08-27

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  KLOETZER W ,  FRANZMAIR R ,  SCHMIDT B

IPC: C07D207/22 ,  C07D207/38 ,  C07D27/14

Abstract: (A) Cmpds. (I) and (III): and tautomeric forms of I and III, where R' = Ph opt. substd. by (1-6Ce alkyl, (1-6C) Oalkyl, or halogen. R2 = Ph opt. substd. by (1-6C) alkyl, (1-6C)O alkyl, or halogen, (5-6C) cycloalkyl, or (5-6C) cycloalkenyl. R3, R4, R5 and R6 = H or (1-6C) alkyl. R7 = H, (1-6C) alkyl, lower carbalkoxy, lower alkyl, N(alkyl)2-lower alkyl, lower alkoxyphenyl, or lower alkoxy-lower alkyl. R8 = H or (1-6C) alkyl. X = O, S, or NH. (B) Acid addn. salts (II) of I. I and II Hypoglycaemics. III Intermediates for I.

公开(公告)号：SE340454B

公开(公告)日：1971-11-22

申请号：SE1150568D

申请日：1968-08-27

Applicant: HOFFMANN LA ROCHE

Inventor： FRANZMAIR R ,  BRETSCHNEIDER H ,  KLOETZER W

IPC: C07D27/04

公开(公告)号：SE331996B

公开(公告)日：1971-01-25

申请号：SE245168

申请日：1968-02-26

Applicant: HOFFMANN LA ROCHE

Inventor： BRETSCHNEIDER H ,  FRANZMAIR B ,  KLOETZER W ,  SCHMIDT B

IPC: C07D207/22 ,  C07D207/38 ,  C07D27/14

Abstract: (A) Cmpds. (I) and (III): and tautomeric forms of I and III, where R' = Ph opt. substd. by (1-6Ce alkyl, (1-6C) Oalkyl, or halogen. R2 = Ph opt. substd. by (1-6C) alkyl, (1-6C)O alkyl, or halogen, (5-6C) cycloalkyl, or (5-6C) cycloalkenyl. R3, R4, R5 and R6 = H or (1-6C) alkyl. R7 = H, (1-6C) alkyl, lower carbalkoxy, lower alkyl, N(alkyl)2-lower alkyl, lower alkoxyphenyl, or lower alkoxy-lower alkyl. R8 = H or (1-6C) alkyl. X = O, S, or NH. (B) Acid addn. salts (II) of I. I and II Hypoglycaemics. III Intermediates for I.

公开(公告)号：YU40388A

公开(公告)日：1990-02-28

申请号：YU40388

申请日：1988-03-01

Applicant: HOFFMANN LA ROCHE

Inventor： KLOETZER W ,  MONTAVON M ,  MUESSNER R ,  SINGEWALD N

IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: Imidazole derivatives of the formula I wherein R1 and R2 each is lower alkyl, X is a residue of the formula R3 is hydrogen and R4 is hydrogen or lower alkyl or R3 and R4 taken together are an additional carbon-nitrogen bond; R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts thereof are described. The compounds of formula I possess valuable pharmacodynamic properties, especially inflammation-inhibiting and edema-inhibiting properties, so that they can be used for the control or prevention of illnesses, especially for the control or prevention of inflammations and edemas.