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公开(公告)号：NO20061907A
公开(公告)日：2006-07-12
申请号：NO20061907
申请日：2006-04-28
Applicant: HOFFMANN LA ROCHE
Inventor： WOSTL WOLFGANG , SARMIENTO ROSA MARIA RODRIGUEZ , THOMAS ANDREW WILLIAM , WYLER RENE , JOLIDON SYNESE
IPC: C07D223/16
CPC classification number: C07D223/16
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公开(公告)号：ZA200408281B
公开(公告)日：2005-10-14
申请号：ZA200408281
申请日：2004-10-13
Applicant: HOFFMANN LA ROCHE
Inventor： CESURA ANDREA , SCALONE MICHELANGELO , WYLER RENE , SARMIENTO ROSA MARIA RODRIGUEZ , THOMAS ANDREW WILLIAM
IPC: C07D217/04 , A61K31/472 , A61P25/16 , A61P25/28 , A61P43/00 , C07D217/24 , C07D405/06 , C07D , A61K , A61P
Abstract: Disclosed are isoquinolino derivatives of the formulawherein Y is >C=O or -CH2-, Z is >C=O or -CH2-, and R , R and m are as defined herein as well as the pharmaceutically acceptable salts thereof. These compounds are MAO-B selective inhibitors useful, inter alia, in the treatment of Alzheimer's disease and/or senile dementia.
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公开(公告)号：AU2004283452A1
公开(公告)日：2005-05-06
申请号：AU2004283452
申请日：2004-10-14
Applicant: HOFFMANN LA ROCHE
Inventor： JOLIDON SYNESE , WOSTL WOLFGANG , THOMAS ANDREW WILLIAM , WYLER RENE , SARMIENTO ROSA MARIA RODRIGUEZ
IPC: C07D223/16
Abstract: The present invention relates to novel benzazepine derivatives of the following formula: wherein R 1 , R 2 , R 3 , R 4 and R 5 , X, X', Y and Y' are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
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公开(公告)号：BR0312658A
公开(公告)日：2005-04-26
申请号：BR0312658
申请日：2003-07-07
Applicant: HOFFMANN LA ROCHE
Inventor： JOLIDON SYNESE , SARMIENTO ROSA MARIA RODRIGUEZ , THOMAS ANDREW WILLIAM , WYLER RENE , WOSTL WOLFGANG
IPC: A61K31/165 , A61K31/275 , A61P25/28 , A61P43/00 , C07C231/02 , C07C231/12 , C07C235/06 , C07C235/28 , C07C235/34 , C07C255/54 , C07C235/54
Abstract: The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula wherein A is selected from R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , R 21 , R 22 , R 23 , R 24 , and n are as defined herein or pharmaceutically acceptable salts thereof. The invention also relates to processes for preparation of such compounds, compositions containing them, and the use of such derivatives as MAO-B inhibitors. The invention further relates to methods for treating or preventing Alzheimer's disease and senile dementia by administering compounds of the invention.
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公开(公告)号：NO20050665A
公开(公告)日：2005-04-18
申请号：NO20050665
申请日：2005-02-08
Applicant: HOFFMANN LA ROCHE
Inventor： WIRZ BEAT , WOSTL WOLFGANG , SARMIENTO ROSA MARIA RODRIGUEZ , THOMAS ANDREW WILLIAM , WYLER RENE , JOLIDON SYNESE , IDING HANS , KRUMMENACHER DANIELA
IPC: A61K31/4015 , A61P25/16 , A61P25/28 , C07D207/26 , C07D207/273 , C07D207/277 , C07D401/04 , A61P25/00
CPC classification number: C07D207/273 , C07D207/277
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Patent Agency Ranking
公开(公告)号：BR0311338A
公开(公告)日：2005-03-22
申请号：BR0311338
申请日：2003-05-20
Applicant: HOFFMANN LA ROCHE
Inventor： JOLIDON SYNESE , SARMIENTO ROSA MARIA RODRIGUEZ , THOMAS ANDREW WILLIAM , WYLER RENE
IPC: A61P3/00 , A61K31/15 , A61K31/167 , A61K31/216 , A61K31/275 , A61P3/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P29/00 , A61P43/00 , C07C231/02 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/60 , C07C235/16 , C07C237/04 , C07C237/22 , C07C243/14 , C07C243/28 , C07C255/19 , C07C255/23 , C07C255/25 , C07C255/58 , C07C259/06 , C07C323/41
Abstract: This invention relates to N-acylamino aryl derivatives of the formula where R 1 , R 21 , R 22 , R 23 , R 24 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R, and n are as defined herein and where X is -CHRO, -OCHR-, -CH 2 S-, -SCH 2 -, -CH 2 CH 2 -, -CH-CH- or -C≡C-. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.
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公开(公告)号：NO20044806A
公开(公告)日：2004-12-29
申请号：NO20044806
申请日：2004-11-04
Applicant: HOFFMANN LA ROCHE
Inventor： SARMIENTO ROSA MARIA RODRIGUEZ , THOMAS ANDREW WILLIAM , WYLER RENE , JOLIDON SYNESE
IPC: A61P3/00 , A61K31/15 , A61K31/167 , A61K31/216 , A61K31/275 , A61P3/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P29/00 , A61P43/00 , C07C231/02 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/60 , C07C235/16 , C07C237/04 , C07C237/22 , C07C243/14 , C07C243/28 , C07C255/19 , C07C255/23 , C07C255/25 , C07C255/58 , C07C259/06 , C07C323/41
CPC classification number: C07C259/06 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/60 , C07C235/16 , C07C237/04 , C07C237/22 , C07C243/14 , C07C243/28 , C07C255/19 , C07C255/23 , C07C255/25 , C07C323/41 , C07C2601/02
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公开(公告)号：UY27990A1
公开(公告)日：2004-03-31
申请号：UY27990
申请日：2003-09-18
Applicant: HOFFMANN LA ROCHE
Inventor： JOLIDON SYNESE , THOMAS ANDREW WILLIAM , WYLER RENE , WIRZ BEAT , IDING HANS , KRUMMENACHER DANIELA , SARMIENTO ROSA MARIA RODRIGUEZ , WOSTL WOLFGANG
IPC: A61K31/4015 , A61P25/16 , A61P25/28 , C07D207/26 , C07D207/273 , C07D207/277 , C07D401/04 , A61P25/00 , C07D207/18 , C07D213/04 , C07D403/04
Abstract: Derivados de 4-pirrolidino racémicos o enantioméricamente puros, procesos para su preparación, composiciones farmacéuticas que comprenden dichos derivados, y su uso en la prevención y tratamiento de enfermedades, en particular las que están mediadas por inhibidores de la monoamino oxidasa B, en particular enfermedades de Alzheimer o demencia senil.
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公开(公告)号：UY27825A1
公开(公告)日：2003-12-31
申请号：UY27825
申请日：2003-05-27
Applicant: HOFFMANN LA ROCHE
Inventor： THOMAS ANDREW WILLIAM , WYLER RENE , SARMIENTO ROSA MARIA RODRIGUEZ
IPC: A61P3/00 , A61K31/15 , A61K31/167 , A61K31/216 , A61K31/275 , A61P3/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P29/00 , A61P43/00 , C07C231/02 , C07C233/15 , C07C233/25 , C07C233/33 , C07C233/60 , C07C235/16 , C07C237/04 , C07C237/22 , C07C243/14 , C07C243/28 , C07C255/19 , C07C255/23 , C07C255/25 , C07C255/58 , C07C259/06 , C07C323/41
Abstract: Esta invención se refiere a derivados N-acilamino arilo de fórmula general Se ha descubierto que los compuestos de fórmula general I son inhibidores selectivos de la monoamino oxidasa, y son por lo tanto de utilidad en el tratamiento de enfermedades mediadas por los inhibidores de la monoamino oxidasa B, por ejemplo, para el tratamiento de la enfermedad de Alzheimer o la demencia senil.
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公开(公告)号：BRPI0814999A2
公开(公告)日：2015-02-03
申请号：BRPI0814999
申请日：2008-07-30
Applicant: HOFFMANN LA ROCHE
Inventor： GOBBI LUCA , JAESCHKE GEORG , SARMIENTO ROSA MARIA RODRIGUEZ , STEWARD LUCINDA
IPC: C07D211/32
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