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公开(公告)号：BR7807115A
公开(公告)日：1979-05-15
申请号：BR7807115
申请日：1978-10-27
Applicant: HOFFMANN LA ROCHE
Inventor： BERNAUER K , STOHLER H , LINK H
IPC: A61K31/215 , A61K31/22 , A61K31/24 , A61P5/00 , A61P33/00 , C07C67/00 , C07C239/00 , C07C275/42 , C07D233/66 , C07D233/72 , C07D233/88 , A61K31/17 , A61K31/415 , C07C127/15
Abstract: Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.
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公开(公告)号：SE7811194L
公开(公告)日：1979-04-29
申请号：SE7811194
申请日：1978-10-27
Applicant: HOFFMANN LA ROCHE
Inventor： BERNAUER K , LINK H , STOHLER H
IPC: A61K31/415 , A61K31/4166 , A61P5/00 , A61P33/10 , C07D233/66 , C07D233/72 , C07D233/74 , C07D233/88
Abstract: Imidazolidine derivatives of the formula I wherein X is oxygen or imino and R is one of the groups their preparation, use as antiandrogenically or schistosomicidally active agents, and corresponding pharmaceutical preparations, are described.
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公开(公告)号：ZW8781A1
公开(公告)日：1981-12-16
申请号：ZW8781
申请日：1981-04-15
Applicant: HOFFMANN LA ROCHE
Inventor： HOFHEINZ W , STOHLER H
IPC: C07D233/92 , A61K31/415 , A61P33/10 , C07D233/91 , C07D , A61K
Abstract: 2-Nitroimidazoles having filaricidal activity of the formula I wherein A is one of the groups -C(R3)=C(R1)(R2),-CHBr-CH2Br or -CH2-CCl=CH2; n is 1, 2, 3 or 4; R1 and R2 are hydrogen or C1-3-alkyl and R3 is hydrogen, C1-3-alkyl, chlorine or bromine, and processes for their preparation are described. The compounds of formula I and compounds of formula VII wherein R4 is -CH2-CH2OH, -CH2-CHOH-CH2OCH3, -CH2-CHOH-CH2OH or are useful in the treatment of filariasis is also described.
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公开(公告)号：AU7064081A
公开(公告)日：1981-11-26
申请号：AU7064081
申请日：1981-05-15
Applicant: HOFFMANN LA ROCHE
Inventor： HOFHEINZ W , STOHLER H
IPC: C07D233/92 , A61K31/415 , A61P33/10 , C07D233/91
Abstract: 2-Nitroimidazoles having filaricidal activity of the formula I wherein A is one of the groups -C(R3)=C(R1)(R2),-CHBr-CH2Br or -CH2-CCl=CH2; n is 1, 2, 3 or 4; R1 and R2 are hydrogen or C1-3-alkyl and R3 is hydrogen, C1-3-alkyl, chlorine or bromine, and processes for their preparation are described. The compounds of formula I and compounds of formula VII wherein R4 is -CH2-CH2OH, -CH2-CHOH-CH2OCH3, -CH2-CHOH-CH2OH or are useful in the treatment of filariasis is also described.
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公开(公告)号：ZA785929B
公开(公告)日：1980-05-28
申请号：ZA785929
申请日：1978-10-20
Applicant: HOFFMANN LA ROCHE
Inventor： BERNAUER K , STOHLER H , LINK H
IPC: A61K20060101 , C07D20060101 , A61K , C07D
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Patent Agency Ranking
公开(公告)号：ZA7805929B
公开(公告)日：1980-05-28
申请号：ZA7805929
申请日：1978-10-20
Applicant: HOFFMANN LA ROCHE
Inventor： BERNAUER K , STOHLER H , LINK H
IPC: A61K20060101 , C07D20060101 , A61K , C07D
CPC classification number: Y02A50/423
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公开(公告)号：BR7807097A
公开(公告)日：1979-05-08
申请号：BR7807097
申请日：1978-10-27
Applicant: HOFFMANN LA ROCHE
Inventor： STOHLER H , BERNAUER K , LINK H
IPC: A61K31/415 , A61K31/4166 , A61P5/00 , A61P33/10 , C07D233/66 , C07D233/72 , C07D233/74 , C07D233/88 , C07D233/70
Abstract: Imidazolidine derivatives of the formula I wherein X is oxygen or imino and R is one of the groups their preparation, use as antiandrogenically or schistosomicidally active agents, and corresponding pharmaceutical preparations, are described.
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公开(公告)号：SE7811193A
公开(公告)日：1979-04-29
申请号：SE7811193
申请日：1978-10-27
Applicant: HOFFMANN LA ROCHE
Inventor： BERNAUER K , LINK H , STOHLER H
IPC: A61K31/215 , A61K31/22 , A61K31/24 , A61P5/00 , A61P33/00 , C07C67/00 , C07C239/00 , C07C275/42 , C07D233/66 , C07D233/72 , C07D233/88 , A61K9/00
CPC classification number: C07D233/72 , A61K31/24 , C07D233/88 , Y02A50/423
Abstract: Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.
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公开(公告)号：SE433304B
公开(公告)日：1984-05-21
申请号：SE7811193
申请日：1978-10-27
Applicant: HOFFMANN LA ROCHE
Inventor： BERNAUER K , LINK H , STOHLER H
IPC: A61K31/215 , A61K31/22 , A61K31/24 , A61P5/00 , A61P33/00 , C07C67/00 , C07C239/00 , C07C275/42 , C07D233/66 , C07D233/72 , C07D233/88 , A61K9/20 , A61K9/48
Abstract: Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.
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公开(公告)号：SE8202106L
公开(公告)日：1982-04-01
申请号：SE8202106
申请日：1982-04-01
Applicant: HOFFMANN LA ROCHE
Inventor： BERNAUER K , LINK H , STOHLER H
IPC: A61K31/215 , A61K31/22 , A61K31/24 , A61P5/00 , A61P33/00 , C07C67/00 , C07C239/00 , C07C275/42 , C07D233/66 , C07D233/72 , C07D233/88 , C07C127/19 , C07D233/28
Abstract: Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.
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