中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.025 seconds)

    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES
    1.
    发明授权
    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES 失效

    公开(公告)号：KR820002388B1

    公开(公告)日：1982-12-29

    申请号：KR820004632

    申请日：1982-10-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  LINK H ,  STOHLER H

    IPC: C07D233/90

    Abstract: The imidazolidines I(R=Cl, CF3; R1=H,F, Cl; R2=H, Cl; Z=O, NH) were prepd. for use as schistosomicides and antiandrogenic substances (test data tabulated). Thus, 3,4-(F3C)CLC6H3NCO reacted with Me2CH(NH2)CN at 100≦̸C to give I(R = CF5, R1 = Cl, R2 = H, Z = NH), which was hydrolyzed to give I(Z = O)

    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES
    2.
    发明授权
    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES 失效

    公开(公告)号：KR820002387B1

    公开(公告)日：1982-12-29

    申请号：KR820004633

    申请日：1982-10-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  LINK H ,  STOHLER H

    IPC: C07D233/72

    Abstract: Title compds. (I; R=II, III, IV, V, VI), useful as an schistosomicide and antiandrogenic substance were prepd. by hydrolyzing Ia. Thus, 61 mg 1-(3-trifluoromethy1-4-chloro-pheny1)-5-imino-4, 4-dimethy1-2-imidazolidinone was dissolved in 4 ml 0.1N HCl, added 2ml H2O and filtrated after 20 hr to give 3-(3-trifluoromethy1-4-chloropheny1)-5,5-dimethylhydantoin(m.p. 156-157.5oC).

    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES
    3.
    发明授权
    PROCESS FOR PREPARING IMIDAZOLIDINE DERIVATIVES 失效

    公开(公告)号：KR820002386B1

    公开(公告)日：1982-12-29

    申请号：KR780003228

    申请日：1978-10-27

    Applicant: HOFFMANN LA ROCHE

    Inventor： BERNAUER K ,  LINK H ,  STOHLER H

    IPC: C07D233/72

    Abstract: The imidazolidines I(R=Cl, CF3; R1=H,F, Cl; R2=H, Cl; Z=O, NH) were prepd. for use as schistosomicides and antiandrogenic substances. Thus, 3, 4-(F3C)ClC6H3NCO reacted with Me2CHCH(NH2)CN at 100≦̸ to give I(R=CF5, R1=Cl, R2=H, z= NH), which washydrolyzed to I(Z=O).

    PROCESS FOR OBTAINING ACYL DERIVATIVE
    8.
    发明专利
    PROCESS FOR OBTAINING ACYL DERIVATIVE 未知

    公开(公告)号：YU70888A

    公开(公告)日：1989-12-31

    申请号：YU70888

    申请日：1988-04-08

    Applicant: HOFFMANN LA ROCHE

    Inventor： FURLENMEIER A ,  GOETSCHI E ,  HEBEISEN P ,  HOFHEIZ W ,  LINK H

    IPC: C07D519/06 ,  A61K31/545 ,  A61P31/04 ,  C07D501/36 ,  C07D501/46 ,  C07D519/00 ,  C07D501/00

    Abstract: Acyl derivatives of the formula I in which R is an acyl group, excluding those acyl groups of the formula in which A is a group of the formulae -NHCO-, -NHCONHCO-, -NHCOCH=CH-, wherein R6 is hydrogen or lower alkyl; R1 and R2 are hydrogen or a protecting group, X is hydrogen, halogen, lower alkoxy, nitro or -OR2, n is 1 or 2, R4 and R5 are hydrogen or together represent an additional bond and Z is a direct bond or carbonyl (where R4 and R5 both represent hydrogen) or a group of the formula -O-B- (where R4 and R5 together represent an additional bond) in which B is a straight-chain, branched or cyclic lower alkylene; and wherein R3 is a substituted bicyclic group of the formulae 7 5 NR7NNN+RE wherein R7 and R8 are independently hydrogen, lower alkyl or trifluoromethyl or, in formulae (a), (b), (e) and (f) together represent alkylene with 3 or 4 carbon atoms, and R', R'' and R''' are independently hydrogen, lower alkyl or lower cycloalkyl; wherein compounds of formula I in which R4 and R5 together represent an additional bond are present in the syn-isomeric form or as a mixture with the anti-isomeric form in which the syn-isomeric form predominates, as well as readily hydrolyzable esters and salts of these compounds and hydrates of the compounds of formula I or of their esters and salts. These compounds are useful as antibiotics.

Patent Agency Ranking