公开(公告)号：KR820002388B1

公开(公告)日：1982-12-29

申请号：KR820004632

申请日：1982-10-14

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: C07D233/90

Abstract: The imidazolidines I(R=Cl, CF3; R1=H,F, Cl; R2=H, Cl; Z=O, NH) were prepd. for use as schistosomicides and antiandrogenic substances (test data tabulated). Thus, 3,4-(F3C)CLC6H3NCO reacted with Me2CH(NH2)CN at 100≦̸C to give I(R = CF5, R1 = Cl, R2 = H, Z = NH), which was hydrolyzed to give I(Z = O)

公开(公告)号：KR820002387B1

公开(公告)日：1982-12-29

申请号：KR820004633

申请日：1982-10-14

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: C07D233/72

Abstract: Title compds. (I; R=II, III, IV, V, VI), useful as an schistosomicide and antiandrogenic substance were prepd. by hydrolyzing Ia. Thus, 61 mg 1-(3-trifluoromethy1-4-chloro-pheny1)-5-imino-4, 4-dimethy1-2-imidazolidinone was dissolved in 4 ml 0.1N HCl, added 2ml H2O and filtrated after 20 hr to give 3-(3-trifluoromethy1-4-chloropheny1)-5,5-dimethylhydantoin(m.p. 156-157.5oC).

公开(公告)号：KR820002386B1

公开(公告)日：1982-12-29

申请号：KR780003228

申请日：1978-10-27

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: C07D233/72

Abstract: The imidazolidines I(R=Cl, CF3; R1=H,F, Cl; R2=H, Cl; Z=O, NH) were prepd. for use as schistosomicides and antiandrogenic substances. Thus, 3, 4-(F3C)ClC6H3NCO reacted with Me2CHCH(NH2)CN at 100≦̸ to give I(R=CF5, R1=Cl, R2=H, z= NH), which washydrolyzed to I(Z=O).

公开(公告)号：NZ188720A

公开(公告)日：1984-12-14

申请号：NZ18872078

申请日：1978-10-24

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: A61K31/215 ,  A61K31/22 ,  A61K31/24 ,  A61P5/00 ,  A61P33/00 ,  C07C67/00 ,  C07C239/00 ,  C07C275/42 ,  C07D233/66 ,  C07D233/72 ,  C07D233/88 ,  C07C127/00 ,  C07D233/00 ,  A61K31/17

Abstract: Imidazolidine derivatives, as well as processes for their preparation, which have antiandrogenic and schistosomicidal activity.

公开(公告)号：NZ188721A

公开(公告)日：1984-11-09

申请号：NZ18872178

申请日：1978-10-24

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: A61K31/415 ,  A61K31/4166 ,  A61P5/00 ,  A61P33/10 ,  C07D233/66 ,  C07D233/72 ,  C07D233/74 ,  C07D233/88 ,  C07D233/00

Abstract: Imidazolidine derivatives of the formula I wherein X is oxygen or imino and R is one of the groups their preparation, use as antiandrogenically or schistosomicidally active agents, and corresponding pharmaceutical preparations, are described.

公开(公告)号：PH13569A

公开(公告)日：1980-06-26

申请号：PH21743

申请日：1978-10-30

Applicant: HOFFMANN LA ROCHE

Inventor： LINK H ,  BERNAUER K ,  STOHLER H

IPC: A61K31/415 ,  A61K31/4166 ,  A61P5/00 ,  A61P33/10 ,  C07D233/66 ,  C07D233/72 ,  C07D233/74 ,  C07D233/88 ,  C07D235/00

Abstract: Imidazolidine derivatives of the formula I wherein X is oxygen or imino and R is one of the groups their preparation, use as antiandrogenically or schistosomicidally active agents, and corresponding pharmaceutical preparations, are described.

公开(公告)号：ZA7805930B

公开(公告)日：1979-09-26

申请号：ZA7805930

申请日：1978-10-20

Applicant: HOFFMANN LA ROCHE

Inventor： STOHLER H ,  LINK H ,  BERNAUER K

IPC: A61K20060101 ,  C07D20060101 ,  C07D

CPC classification number: Y02A50/423

公开(公告)号：SE7811194A

公开(公告)日：1979-04-29

申请号：SE7811194

申请日：1978-10-27

Applicant: HOFFMANN LA ROCHE

Inventor： BERNAUER K ,  LINK H ,  STOHLER H

IPC: A61K31/415 ,  A61K31/4166 ,  A61P5/00 ,  A61P33/10 ,  C07D233/66 ,  C07D233/72 ,  C07D233/74 ,  C07D233/88

CPC classification number: C07D233/88 ,  C07D233/72

公开(公告)号：BR8103216A

公开(公告)日：1982-02-16

申请号：BR8103216

申请日：1981-05-22

Applicant: HOFFMANN LA ROCHE

Inventor： STOHLER H ,  HOFHEINZ W

IPC: C07D233/92 ,  A61K31/415 ,  A61P33/10 ,  C07D233/91

Abstract: 2-Nitroimidazoles having filaricidal activity of the formula I wherein A is one of the groups -C(R3)=C(R1)(R2),-CHBr-CH2Br or -CH2-CCl=CH2; n is 1, 2, 3 or 4; R1 and R2 are hydrogen or C1-3-alkyl and R3 is hydrogen, C1-3-alkyl, chlorine or bromine, and processes for their preparation are described. The compounds of formula I and compounds of formula VII wherein R4 is -CH2-CH2OH, -CH2-CHOH-CH2OCH3, -CH2-CHOH-CH2OH or are useful in the treatment of filariasis is also described.

公开(公告)号：ZA785930B

公开(公告)日：1979-09-26

申请号：ZA785930

申请日：1978-10-20

Applicant: HOFFMANN LA ROCHE

Inventor： STOHLER H ,  LINK H ,  BERNAUER K

IPC: A61K20060101 ,  C07D20060101 ,  C07D