METHOD OF PRODUCING INORGANIC ACID SALT OF AMINO ACID ESTER

    公开(公告)号:JP2001181247A

    公开(公告)日:2001-07-03

    申请号:JP37278999

    申请日:1999-12-28

    Applicant: KYOWA YUKA KK

    Abstract: PROBLEM TO BE SOLVED: To provide a method of efficiently and simply producing an inorganic acid salt of protected or unprotected amino acid esters useful as a raw material for peptide synthesis, raw materials for medicine and the like. SOLUTION: In this method for producing an inorganic acid salt of protected or unprotected amino acid salt by subjecting a protected or unprotected amino acid or their inorganic acid salt and an alcohol to the esterification reaction to produce inorganic acid salt of protected or unprotected amino acid ester, the reaction process characteristically comprises: (1) the step where the esterification reaction is carried out in the presence of thionyl chloride; (2) the step where the crystals of the inorganic acid of the protected or unprotected amino acid ester is filtered after completion of the esterification reaction; (3) in addition, the filtrate is additionally subjected to the following esterification reaction.

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