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公开(公告)号：DE102005045165A1
公开(公告)日：2007-03-29
申请号：DE102005045165
申请日：2005-09-21
Applicant: LEICA MICROSYSTEMS
Inventor： WEIS ALBRECHT , GANSER MICHAEL
IPC: G02B21/00
Abstract: The system (1) has a dichromatic beam splitter (3) and a blocking filter (4) that are formed as a thin film system with a thin layer on a transparent substrate. A divider-substrate of the beam splitter and/or a blocking filter substrate is formed as a wedge plate with a wedge angle. The divider-substrate and/or the blocking filter substrate is adjustable such that beam deflection in the system opposite to an optical axis (7) is minimized.
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公开(公告)号：DE50206506D1
公开(公告)日：2006-05-24
申请号：DE50206506
申请日：2002-11-28
Applicant: LEICA MICROSYSTEMS
Inventor： GANSER MICHAEL , WESNER JOACHIM
Abstract: A method for blind deconvolution of microscopic images in which only a single parameter is varied for the estimation of the PSF. The single parameter takes account of the optical properties of the environment of the object ( 40 ) between the objective ( 20 ) of the microscope ( 1 ) and the region above the object. The single parameter represents a functional relationship among the parameters of the individual layers.
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公开(公告)号：DE102004026093B4
公开(公告)日：2006-04-13
申请号：DE102004026093
申请日：2004-05-25
Applicant: LEICA MICROSYSTEMS
Inventor： GANSER MICHAEL
Abstract: A system for acquiring and displaying images of preparations is provided. The system includes a first and second illumination device, each including an illumination source defining a respective illumination beam path amid configured to emit light to illuminate the preparation. A camera and a display for displaying a portion of the preparation are further provided. The preparation can be placed on a stage that is movable in x and y coordinate directions. The frame is also provided with a combining device configured to combine the first imaging beam path and the second imaging beam path, and direct them to the camera.
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公开(公告)号：DE10246276A1
公开(公告)日：2004-04-15
申请号：DE10246276
申请日：2002-10-02
Applicant: LEICA MICROSYSTEMS
Inventor： SCHWAAB KLAUS , GANSER MICHAEL
IPC: G02B21/26
Abstract: The specimen stage has a coaxial drive which is attached to a second stage member (2), and moves a drive gearwheel which meshes with a toothed rack arranged on a first stage member (1). A pulling mechanism (11) is provided for displacing a third stage member. An Independent claim is included for a microscope comprising the specimen stage.
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公开(公告)号：DE59900684D1
公开(公告)日：2002-02-21
申请号：DE59900684
申请日：1999-03-11
Applicant: LEICA MICROSYSTEMS
Inventor： GANSER MICHAEL
Abstract: Process for video microscopy in which an image of an object ( 9 ) on a microscope stage ( 7 ) generated by a microscope ( 1 ) is recorded with a video camera, digitized, stored temporarily, and displayed on the monitor ( 13 ) of a personal computer ( 12 ). At one known magnification V 1 , an image detail ( 15 ) is selected. Its image coordinates {right arrow over (r 1 =(x 1 , y 1 ) relative to the center ( 18 ) of the image on the monitor screen ( 17 ) are determined at the proper scale. After a change in magnification from magnification V 1 to another magnification V m the position of the image detail ( 15 ) on the monitor screen is kept the same by moving the microscope stage ( 7 ) in the proper direction by {right arrow over (r 1 (1/V m -1/V).
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Patent Agency Ranking
公开(公告)号：DE10018255A1
公开(公告)日：2001-10-25
申请号：DE10018255
申请日：2000-04-13
Applicant: LEICA MICROSYSTEMS
Inventor： GANSER MICHAEL , WEIS ALBRECHT , STENZEL RUEDIGER
Abstract: The laser cutting method involves bringing an object carrier (10) with a sample (12) to be cut into a microscope (1) which has at least one objective lens (6). Using the objective lens, a region to be cut out is determined. A cut line is defined around the region. A laser beam (4b) is generated through an aperture (18) so that its diameter is reduced such that a laser aperture (36) generated through the lens (6) is smaller than the lens aperture (34) of the lens itself. The sample is then cut along the cut line. Independent claims also cover an apparatus for carrying out the method.
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公开(公告)号：DE10018251A1
公开(公告)日：2001-10-25
申请号：DE10018251
申请日：2000-04-13
Applicant: LEICA MICROSYSTEMS
Inventor： GANSER MICHAEL , WEIS ALBRECHT , STENZEL RUEDIGER
Abstract: A laser micro-dissection microscope has a table for a sample illuminated by a laser light source with a lens-focused beam. The table is fixed in both the X and Y axes during dissection. The laser has a scanner with two thick wedge-shaped glass panels. The panels are inclined with respect to the optical axis and may be rotated independently of each other about the axis. A laser micro-dissection microscope has a table (1) for a sample (3) illuminated by a laser (7) light source (5) with a lens-focused (10) beam (18). The table is fixed in both the X and Y axes during dissection. The laser (7) has a scanner (9) with two thick wedge-shaped glass panels (11a,11b). The panels are inclined with respect to the optical axis (8) and may be rotated independently of each other about the axis. Rotation deflects the beam about the axis by an angle alpha. The laser beam is offset laterally with respect to the optical axis (8) by the thickness and angle of the glass panels and impinges on the center of the lens pupil (19) for all alpha angles. The laser light source is an ultra violet or VIS laser. The wedge-shaped glass panels are rotated as required by electric motors (14a,14b) with control units. The dissection unit is linked to a computer (26) with a mouse and a monitor screen (28). The computer is coupled to the motor control and laser light source. Also claimed is a process in which the preparation remains fixed while being progressively sliced in steps by the laser beam. An image of the preparation is captured by a camera (16) and presented on the monitor screen (28).
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公开(公告)号：DE19845603A1
公开(公告)日：2000-05-04
申请号：DE19845603
申请日：1998-10-05
Applicant: LEICA MICROSYSTEMS
Inventor： WEIS ALBRECHT , GANSER MICHAEL , RUEHL ERNST , GILBERT MANFRED
Abstract: The invention relates to an illumination device (1) for a microscope, whereby a first light source (2), a collector lens (3), an aperture diaphragm (4) and a condenser lens (5) are arranged in the path of an illuminating beam (6). The illuminating light is directed through the aperture diaphragm via the condenser lens (5) into the object plane (9). A second light source (8) is arranged in the path of the illuminating beam on an optical axis and is projected in an infinite manner from the condenser lens onward.
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公开(公告)号：DE102010060841B3
公开(公告)日：2012-06-06
申请号：DE102010060841
申请日：2010-11-26
Applicant: LEICA MICROSYSTEMS
Inventor： GANSER MICHAEL
IPC: G02B21/24
Abstract: Beschrieben ist eine Einrichtung zum Fokussieren eines Mikroskopobjektivs (26) auf eine Probe (18). Die Einrichtung umfasst eine Positioniereinheit (20) mit einem Grundkörper (22), einem an dem Grundkörper beweglich gelagerten Objektivhalter (24) zum Halten des Mikroskopobjektivs (26) und einem Aktor (27) zum Bewegen des Objektivhalters (24) längs der optischen Achse (O) des Mikroskopobjektivs. Der Objektivhalter hält einen der Probe (18) zugewandten Frontabschnitt des Mikroskopobjektivs (26).
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公开(公告)号：DE102005045165B4
公开(公告)日：2008-04-17
申请号：DE102005045165
申请日：2005-09-21
Applicant: LEICA MICROSYSTEMS
Inventor： WEIS ALBRECHT , GANSER MICHAEL
IPC: G02B21/00
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