公开(公告)号：AT80138T

公开(公告)日：1992-09-15

申请号：AT87907350

申请日：1987-11-10

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TANIGUCHI KATSUO ,  TANAKA MICHIO ,  TAKAHATA KAZUNORI ,  SAKAMOTO NAOYA ,  TAKAI TOSHIHIRO ,  KURANO YOSHITO ,  ISHIBASHI MASAYASU

IPC: B01J29/18 ,  B01J29/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/66 ,  C07C2/86 ,  C07C15/00 ,  C07C15/02 ,  C07C15/14 ,  C07C15/16 ,  C07C15/24 ,  C07C37/08 ,  C07C39/15 ,  C07C43/263 ,  C07C67/00 ,  C07C67/08

Abstract: This improved process for producing alkyl group-substd. aromatic hydrocarbons comprises reacting an aromatic hydrocarbon (1) with an alkylating agent (2) in the presence of a mordenite zeolite catalyst treated with a fluorine-contg. cpd. The alkylating agent (2) is selected from olefins, aliphatic lower alcohols, and alkyl halides (pref. propylene). The pref. aromatic hydrocarbon (1) is biphenyl, dibiphenyl or naphthalene. The typical product is p,p'-diisopropylbiphenyl. The fluorine-contg. cpds. can be hydrogen fluoride, ammonium fluoride, CF3Cl, SF6. As an example, 4,4'-dihydroxybiphenyl is produced by the acid-decomposition of 4,4'-diisopropyl biphenyldihydroperoxide which is obtd. by oxidising 4,4'-diisopropylbiphenyl with oxygen molecules. The above 4,4'-diisopropylbiphenyl is reacted with acylising agent to obtain 4,4'-diacyloxybiphenyl.

公开(公告)号：HU205362B

公开(公告)日：1992-04-28

申请号：HU544389

申请日：1989-10-25

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07D519/04

公开(公告)号：HU901273D0

公开(公告)日：1990-05-28

申请号：HU127390

申请日：1990-03-02

Applicant: MITSUI PETROCHEMICAL IND

Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

IPC: C07D519/04

Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

公开(公告)号：HU209687B

公开(公告)日：1994-10-28

申请号：HU127390

申请日：1990-03-02

Applicant: MITSUI PETROCHEMICAL IND

Inventor： KIHARA NORIAKI ,  HATA EIICHIROU ,  SAKAMOTO NAOYA ,  TAN HIROAKI

IPC: C07D519/04

Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

公开(公告)号：DE69002489T2

公开(公告)日：1993-12-02

申请号：DE69002489

申请日：1990-03-05

Applicant: MITSUI PETROCHEMICAL IND

Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

IPC: C07D519/04

Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

公开(公告)号：AT102946T

公开(公告)日：1994-04-15

申请号：AT89308089

申请日：1989-08-09

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07D519/04

公开(公告)号：DE3781547T2

公开(公告)日：1993-01-07

申请号：DE3781547

申请日：1987-11-10

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TANIGUCHI KATSUO ,  TANAKA MICHIO ,  TAKAHATA KAZUNORI ,  SAKAMOTO NAOYA ,  TAKAI TOSHIHIRO ,  KURANO YOSHITO ,  ISHIBASHI MASAYASU

IPC: B01J29/18 ,  B01J29/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/66 ,  C07C2/86 ,  C07C15/00 ,  C07C15/02 ,  C07C15/14 ,  C07C15/16 ,  C07C15/24 ,  C07C37/08 ,  C07C39/15 ,  C07C43/263 ,  C07C67/00 ,  C07C67/08

Abstract: This improved process for producing alkyl group-substd. aromatic hydrocarbons comprises reacting an aromatic hydrocarbon (1) with an alkylating agent (2) in the presence of a mordenite zeolite catalyst treated with a fluorine-contg. cpd. The alkylating agent (2) is selected from olefins, aliphatic lower alcohols, and alkyl halides (pref. propylene). The pref. aromatic hydrocarbon (1) is biphenyl, dibiphenyl or naphthalene. The typical product is p,p'-diisopropylbiphenyl. The fluorine-contg. cpds. can be hydrogen fluoride, ammonium fluoride, CF3Cl, SF6. As an example, 4,4'-dihydroxybiphenyl is produced by the acid-decomposition of 4,4'-diisopropyl biphenyldihydroperoxide which is obtd. by oxidising 4,4'-diisopropylbiphenyl with oxygen molecules. The above 4,4'-diisopropylbiphenyl is reacted with acylising agent to obtain 4,4'-diacyloxybiphenyl.

公开(公告)号：HUT56845A

公开(公告)日：1991-10-28

申请号：HU544389

申请日：1989-10-25

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07D519/04

Abstract: Method for producing a dimeric alkaloid comprises reacting catharanthine with vindoline in the presence of ferric ion, and either (i) removing or inactivating the ferric ion and reacting the prod. with a reducing agent, or (ii) adding oxygen and a dicarboxylic acid or deriv. to the reaction system and reacting the prod. with a hydride source.

公开(公告)号：HUT54167A

公开(公告)日：1991-01-28

申请号：HU127390

申请日：1990-03-02

Applicant: MITSUI PETROCHEMICAL IND

Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

IPC: C07D519/04

Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

公开(公告)号：JPH07215923A

公开(公告)日：1995-08-15

申请号：JP1114294

申请日：1994-02-02

Applicant: MITSUI PETROCHEMICAL IND

Inventor： DOI YASUSHI ,  SAKAMOTO NAOYA ,  OYOSHI HAJIME

IPC: C07C213/02 ,  C07C215/76

Abstract: PURPOSE:To high selectively produce an aminophenol in a high yield by conducting an amination reaction of a divalent phenol in the presence of a mixture of phenol and another phenolic compound other than phenol. CONSTITUTION:In synthesizing an aminophenol of formula III by aminating a divalent phenol of formula I (R is H, a halogen or a lower alkyl) using a compound of formula II (R and R are H, a 1 to 10C alkyl, a 4 to 8C cycloalkyl), this reaction is conducted in the presence of a mixture of phenol and a phenolic compound other than phenol. As the phenol mixture, a mixture composed of phenol and one or more kinds of phenolic compounds selected from a group of cresols, chlorophenols, bromophenols and biphenols is used and a mixture of phenol and a biphenol is especially preferable. As the dihydric phenol of formula I, resorcin or hydroquinone is especially preferable. This aminophenol is useful as an intermediate for synthesis of agricultural and medical drugs and a raw material for pressure-sensitive or heat-sensitive dyes.