公开(公告)号：EP3209370A4

公开(公告)日：2018-05-30

申请号：EP15851950

申请日：2015-10-22

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  FRANKE MANFRED ,  HAMILTON DANIEL N ,  DORAISWAMY ANAND ,  ACKERMANN DOUGLAS MICHAEL

IPC: A61N1/36 ,  A61N1/378

CPC classification number: A61N1/3787 ,  A61N1/36046 ,  A61N1/36121 ,  B29D11/00038 ,  B29D11/00826

Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

公开(公告)号：EP3110405A4

公开(公告)日：2017-10-18

申请号：EP15754827

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61K9/14 ,  C08F220/54 ,  C08F222/10 ,  C08F226/10 ,  C08F230/08

CPC classification number: A61N1/0546 ,  A61N1/0456 ,  A61N1/0496 ,  A61N1/36014 ,  C08F220/54 ,  C08F230/08 ,  H01B1/125 ,  Y10T29/49826 ,  Y10T29/49885 ,  C08F226/10 ,  C08F220/20 ,  C08F2222/1013 ,  C08F2230/085

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.