-
公开(公告)号：WO2015130707A3
公开(公告)日：2015-11-26
申请号：PCT/US2015017379
申请日：2015-02-24
Applicant: OCULEVE INC
Inventor： LOUDIN JAMES DONALD , GUPTA AMITAVA , WARDLE JOHN , STIVERS CHRISTOPHER WILLIAM , DORAISWAMY ANAND , CHRIST MARIE DVORAK , CHRIST F RICHARD
IPC: A61K9/14
CPC classification number: A61N1/0546 , A61N1/0456 , A61N1/0496 , A61N1/36014 , C08F220/54 , C08F230/08 , H01B1/125 , Y10T29/49826 , Y10T29/49885 , C08F226/10 , C08F220/20 , C08F2222/1013 , C08F2230/085
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
Abstract translation: 本文描述的是用于促进鼻或鼻窦组织的电刺激的聚合物制剂。 聚合物制剂可以是通过UV交联方法制备的水凝胶。 可以将水凝胶作为鼻刺激装置的组分包含，以刺激泪腺以改善泪液的产生并治疗干眼症。 此外，本文描述了用于制造鼻刺激器的装置和方法，包括水凝胶的成形。
-
公开(公告)号：WO2014172693A2
公开(公告)日：2014-10-23
申请号：PCT/US2014034733
申请日：2014-04-18
Applicant: OCULEVE INC
Inventor： ACKERMAN DOUGLAS MICHAEL , LOUDIN JAMES DONALD , WARDLE JOHN , BALDWIN JARREN ARMOND , HAMILTON DANIEL N , KUZMA JNAUSZ , STIVERS CHRISTOPHER WILLIAM
CPC classification number: A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
Abstract translation: 这里描述了通过向鼻腔或鼻窦组织提供刺激来治疗一种或多种病症（如干眼症）或改善眼部健康的装置，系统和方法。 通常，设备可以是手持式的或可植入的。 在一些变型中，手持装置可以具有刺激器主体和具有一个或多个鼻插入尖端的刺激器探针。 当装置和系统用于治疗干眼症时，可以刺激鼻或鼻窦组织以增加泪液产生，减少干眼症状和/或改善眼部表面的健康。
-
公开(公告)号：ES2812752T3
公开(公告)日：2021-03-18
申请号：ES15754827
申请日：2015-02-24
Applicant: OCULEVE INC
Inventor： LOUDIN JAMES DONALD , GUPTA AMITAVA , WARDLE JOHN , STIVERS CHRISTOPHER WILLIAM , DORAISWAMY ANAND , CHRIST MARIE DVORAK , CHRIST F RICHARD
IPC: A61K9/14 , C08F220/54 , C08F222/10 , C08F226/10 , C08F230/08
Abstract: Formulación para estimulación eléctrica de tejido nasal o sinusal, que comprende: un primer monómero; un segundo monómero; un fotoiniciador; y un diluyente seleccionado del grupo que consiste en glicerina, metanol, polietilenglicol y combinaciones de los mismos, en la que el primer monómero es un monómero de acrilato seleccionado de un monómero monofuncional, un monómero difuncional y un monómero trifuncional, y el segundo monómero se selecciona del grupo que consiste en dimetilacrilamida, metacrilato de glicidilo, Nvinilpirrolidona y diacrilato de 1,4-butanodiol, y el primer monómero y el segundo monómero no son el mismo tipo de monómero.
-
公开(公告)号：AU2020281058A1
公开(公告)日：2021-01-07
申请号：AU2020281058
申请日：2020-12-02
Applicant: OCULEVE INC
Inventor： FRANKE MANFRED , LOUDIN JAMES DONALD , WARDLE JOHN , HOLDBROOK MARK JEFFREY
IPC: A61N1/36
Abstract: STIMULATION DEVICES AND METHODS FOR TREATING DRY EYE Abstract Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
-
公开(公告)号：AU2015223184B2
公开(公告)日：2020-07-02
申请号：AU2015223184
申请日：2015-02-24
Applicant: OCULEVE INC
Inventor： LOUDIN JAMES DONALD , GUPTA AMITAVA , WARDLE JOHN , STIVERS CHRISTOPHER WILLIAM , DORAISWAMY ANAND , CHRIST MARIE DVORAK , CHRIST F RICHARD
IPC: A61K9/14
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
-
Patent Agency Ranking
公开(公告)号：AU2015335776B2
公开(公告)日：2020-09-03
申请号：AU2015335776
申请日：2015-10-22
Applicant: OCULEVE INC
Inventor： FRANKE MANFRED , LOUDIN JAMES DONALD , WARDLE JOHN , HOLDBROOK MARK JEFFREY
IPC: A61N1/36
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
-
公开(公告)号：AU2015203275A1
公开(公告)日：2015-07-09
申请号：AU2015203275
申请日：2015-06-16
Applicant: OCULEVE INC
Inventor： ACKERMANN DOUGLAS MICHAEL , LOUDIN JAMES DONALD , WARDLE JOHN , BALDWIN JARREN ARMOND , HAMILTON DANIEL N , KUZMA JANUSZ , STIVERS CHRISTOPHER WILLIAM
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health. WO 2014/172693 PCT/US2014/034733 100-% 118 0 o142
-
公开(公告)号：AU2014253754A1
公开(公告)日：2015-02-26
申请号：AU2014253754
申请日：2014-04-18
Applicant: OCULEVE INC
Inventor： ACKERMANN DOUGLAS MICHAEL , LOUDIN JAMES DONALD , WARDLE JOHN , BALDWIN JARREN ARMOND , HAMILTON DANIEL N , KUZMA JANUSZ , STIVERS CHRISTOPHER WILLIAM
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
-
公开(公告)号：EP3209372A4
公开(公告)日：2018-08-01
申请号：EP15853425
申请日：2015-10-22
Applicant: OCULEVE INC
Inventor： FRANKE MANFRED , LOUDIN JAMES DONALD , WARDLE JOHN , HOLDBROOK MARK JEFFREY
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
-
公开(公告)号：ES2809599T3
公开(公告)日：2021-03-04
申请号：ES15853425
申请日：2015-10-22
Applicant: OCULEVE INC
Inventor： FRANKE MANFRED , LOUDIN JAMES , WARDLE JOHN , HOLDBROOK MARK
Abstract: Dispositivo para suministrar un estímulo eléctrico a la mucosa nasal de un paciente, que comprende: una sonda de estimulador que comprende una punta de inserción nasal, una parte distal de la punta de inserción nasal comprende electrodos primero y segundo, en el que el primer electrodo está configurado para suministrar corriente; caracterizado porque un contacto de retorno está ubicado en la sonda de estimulador en la base de la punta de inserción nasal; y una interfaz de usuario está configurada para permitir que el paciente ajuste una cantidad de corriente suministrada entre los electrodos primero y segundo y entre el primer electrodo y el contacto de retorno.
-
-
-
-
-
-
-
-
-
Search Results
30
records
(took 0.038 seconds)
