公开(公告)号：WO2015130707A3

公开(公告)日：2015-11-26

申请号：PCT/US2015017379

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61K9/14

CPC classification number: A61N1/0546 ,  A61N1/0456 ,  A61N1/0496 ,  A61N1/36014 ,  C08F220/54 ,  C08F230/08 ,  H01B1/125 ,  Y10T29/49826 ,  Y10T29/49885 ,  C08F226/10 ,  C08F220/20 ,  C08F2222/1013 ,  C08F2230/085

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

Abstract translation: 本文描述的是用于促进鼻或鼻窦组织的电刺激的聚合物制剂。 聚合物制剂可以是通过UV交联方法制备的水凝胶。 可以将水凝胶作为鼻刺激装置的组分包含，以刺激泪腺以改善泪液的产生并治疗干眼症。 此外，本文描述了用于制造鼻刺激器的装置和方法，包括水凝胶的成形。

公开(公告)号：ES2812752T3

公开(公告)日：2021-03-18

申请号：ES15754827

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61K9/14 ,  C08F220/54 ,  C08F222/10 ,  C08F226/10 ,  C08F230/08

Abstract: Formulación para estimulación eléctrica de tejido nasal o sinusal, que comprende: un primer monómero; un segundo monómero; un fotoiniciador; y un diluyente seleccionado del grupo que consiste en glicerina, metanol, polietilenglicol y combinaciones de los mismos, en la que el primer monómero es un monómero de acrilato seleccionado de un monómero monofuncional, un monómero difuncional y un monómero trifuncional, y el segundo monómero se selecciona del grupo que consiste en dimetilacrilamida, metacrilato de glicidilo, Nvinilpirrolidona y diacrilato de 1,4-butanodiol, y el primer monómero y el segundo monómero no son el mismo tipo de monómero.

公开(公告)号：AU2015223184B2

公开(公告)日：2020-07-02

申请号：AU2015223184

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61K9/14

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：AU2020250288A1

公开(公告)日：2020-11-05

申请号：AU2020250288

申请日：2020-10-09

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  FRANKE MANFRED ,  HAMILTON DANIEL N ,  DORAISWAMY ANAND ,  ACKERMANN DOUGLAS MICHAEL

IPC: A61N1/36

Abstract: CONTACT LENS FOR INCREASING TEAR PRODUCTION Abstract Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

公开(公告)号：AU2015223184A1

公开(公告)日：2016-08-25

申请号：AU2015223184

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61K9/14

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：AU2015335772B2

公开(公告)日：2020-07-09

申请号：AU2015335772

申请日：2015-10-22

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  FRANKE MANFRED ,  HAMILTON DANIEL N ,  DORAISWAMY ANAND ,  ACKERMANN DOUGLAS MICHAEL

IPC: A61N1/36

Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

公开(公告)号：ZA201605563B

公开(公告)日：2017-09-27

申请号：ZA201605563

申请日：2016-08-11

Applicant: OCULEVE INC

Inventor： CHRIST F RICHARD ,  CHRIST MARIE DVORAK ,  DORAISWAMY ANAND ,  STIVERS CHRISTOPHER WILLIAM ,  WARDLE JOHN ,  GUPTA AMITAVA ,  LOUDIN JAMES DONALD

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：AU2015335772A1

公开(公告)日：2017-05-18

申请号：AU2015335772

申请日：2015-10-22

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  FRANKE MANFRED ,  HAMILTON DANIEL N ,  DORAISWAMY ANAND ,  ACKERMANN DOUGLAS MICHAEL

IPC: A61N1/36

Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

公开(公告)号：CA2965514A1

公开(公告)日：2016-04-28

申请号：CA2965514

申请日：2015-10-22

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  FRANKE MANFRED ,  HAMILTON DANIEL N ,  DORAISWAMY ANAND ,  ACKERMANN DOUGLAS MICHAEL

IPC: A61N1/36

Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

公开(公告)号：CA2940533A1

公开(公告)日：2015-09-03

申请号：CA2940533

申请日：2015-02-24

Applicant: OCULEVE INC

Inventor： LOUDIN JAMES DONALD ,  GUPTA AMITAVA ,  WARDLE JOHN ,  STIVERS CHRISTOPHER WILLIAM ,  DORAISWAMY ANAND ,  CHRIST MARIE DVORAK ,  CHRIST F RICHARD

IPC: A61N1/05 ,  A61N1/36 ,  H01B1/12

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.