公开(公告)号：JPS6036463A

公开(公告)日：1985-02-25

申请号：JP14391683

申请日：1983-08-08

Applicant: GRELAN PHARMACEUTICAL CO ,  PERMACHEM ASIA LTD

Inventor： KIKAZAWA KAZUO ,  HIIRAGI MINEJI ,  SAWABE TAKASHI ,  WAKIZAKA KIKUO ,  IRINO OSAMU ,  KOUNO OSAMU ,  MISAKI NORIYUKI ,  MURAYAMA YUU ,  ISHII KIYOSHI ,  NAMIKI YOSHIE

IPC: A61K31/415 ,  A61K31/4166 ,  A61P1/04 ,  A61P17/00 ,  C07D233/72 ,  C07D233/88

Abstract: NEW MATERIAL:An allantoin derivative shown by the formula I (R is lower alkyl, cycloalkyl, or aryl; this lower alkyl group may be replaced with hydroxyl group or alkoxycarbonyl group). EXAMPLE:8-(1'Hydroxymethylpropyl)allantoin. USE:Showing antipeptic ulcer action, suppressing action on gastriointestinal disorder, protecting action on the skin, remedying action on skin disease or trauma, useful as an antipeptic ulcer, remedy for wound, etc. Also useful as an intermediate for synthesizing drugs. Being administered orally and parenterally. PREPARATION:A compound shown by the formula II is condensed with an amine shown by the formula R-NH2, to give a compound shown by the formula I . The condensation is preferably carried out by using a condensation agent such as N,N'-dicyclohexylcarbodiimide or its derivative, or N-ethoxycarbonyl-2- ethoxy-1,2-dihydroquinoline, etc.

公开(公告)号：JP2007291033A

公开(公告)日：2007-11-08

申请号：JP2006122702

申请日：2006-04-26

Applicant: Permachem Asia Ltd ,  株式会社パーマケム・アジア

Inventor： TSUKAHARA TATSUYA ,  OWAKI KEIJI ,  ISHII KIYOSHI

IPC: C07F9/58

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing type-A crystal of 3-pyridyl-1-hydroxy-1,1-bisphosphonic acid sodium salt 2.5 hydrate.
SOLUTION: The production method comprises (1) a step to dissolve 1-2 equivalent of an alkali metal hydroxide to a 8:2 mixture of water and an organic solvent and add the obtained liquid to a mixture of an aqueous suspension of 3-pyridyl-1,1-bisphosphonic acid and an organic solvent at a volume ratio of 7:3 to 9:1, (2) a step to heat the mixture at 45-90°C for 1-3 hr and (3) a step to cool the mixture.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供3-吡啶基-1-羟基-1,1-二膦酸钠盐2.5水合物的A型晶体的制造方法。 解决方案：制备方法包括（1）将1-2当量碱金属氢氧化物溶解在水和有机溶剂的8:2混合物中的步骤，并将得到的液体加入到 3-吡啶基-1,1-二膦酸和有机溶剂，体积比为7:3至9:1，（2）在45-90℃下加热混合物1-3小时和（3 ）冷却混合物的步骤。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JPS6393750A

公开(公告)日：1988-04-25

申请号：JP23914986

申请日：1986-10-09

Applicant: PERMACHEM ASIA LTD

Inventor： ISHII KIYOSHI ,  WATANABE MICHIO

IPC: A01N33/20 ,  C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/28 ,  C07C205/29

Abstract: NEW MATERIAL:Methylene-bis-(2,2-dibromo-2-nitroethyl)ether shown by formula I. USE:Showing strongly germicidal action on bacteria and fungi and useful as a germicide, antiseptic, mildewcide, etc. PREPARATION:A compound shown by formula II is reacted with formaldehyde or paraformaldehyde in the presence of an acidic catalyst to give a compound shown by formula I. The compound of formaldehyde used is preferably 0.3-0.7mol based on 1mol compound shown by formula II. The reaction temperature is 25-150 deg.C, preferably 60-90 deg.C. The starting compound shown by formula II is synthesized by condensing formaldehyde with nitromethane by a caustic alkali and treating the condensate with bromine.

公开(公告)号：JPS62185002A

公开(公告)日：1987-08-13

申请号：JP2401986

申请日：1986-02-07

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  UEJIMA TAKUO ,  FUKUDA TAKESHI ,  ISHII KIYOSHI

IPC: A01N35/04 ,  D21H21/04

Abstract: PURPOSE:To provide the titled controlling agent containing a specific halogen- containing acetophenone compound as an active component, exhibiting excellent antibacterial activity and effective in controlling slime in process water in the paper-making industry. CONSTITUTION:The objective agent contains a compound of formula (X is F, Cl or Br; m and n are 1 or 2), e.g. alpha-bromo-2-bromoacetophenone, alpha,alpha- dibromo-4-fluoroacetophenone, etc., as an active component. The compound of formula can be easily produced e.g. by brominating methyl halogenophenyl ketone with Br2 in an inert solvent such as CCl4. The compound is used in the form of solution or suspension by dissolving in a solvent such as dimethylsulfoxide, xylene, etc., or suspended in water as fine particles. Sufficient effect can be attained by adding the controlling agent to the process water for paper-making at a concentration of 0.1-100ppm in terms of the active component.

公开(公告)号：JPS56122345A

公开(公告)日：1981-09-25

申请号：JP2612280

申请日：1980-03-04

Applicant: PERMACHEM ASIA LTD

Inventor： TOKUNAGA HISATOKU ,  OONO ATSUKO ,  ONO TAKESHI ,  ISHII KIYOSHI ,  SHINNO HIDEKI

IPC: A61K31/195 ,  A61P1/00 ,  C07C67/00 ,  C07C325/00 ,  C07C381/12

Abstract: NEW MATERIAL:A compound of formula (n is 1-3). EXAMPLE:Dihydroxyaluminum methioninate-S-methyl chloride. USE:Remedy for peptic ulcer. The compound is stable and can be easily prepared. PROCESS:The compound of formula can be prepared by reacting S-methylmethionine sulfonium chloride with a compound of formula Al(OR)3 (R is H or lower alkyl). The value of n in the formula can be adjusted to a desired value by selecting the molar ratio of the raw materials.

公开(公告)号：JPS54160357A

公开(公告)日：1979-12-19

申请号：JP6730078

申请日：1978-06-06

Applicant: PERMACHEM ASIA LTD

Inventor： ISHII KIYOSHI ,  YOKOGOE KIYONORI

IPC: C07C49/753 ,  C07C45/00 ,  C07C49/84 ,  C07C67/00

公开(公告)号：JP2015051956A

公开(公告)日：2015-03-19

申请号：JP2013185970

申请日：2013-09-09

Applicant: 株式会社パーマケム・アジア ,  Permachem Asia Ltd

Inventor： MIWA KAZUTOMO ,  TANIGAWA KEIICHIRO ,  SUGIURA MICHIHARU ,  INAGAKI NOBUYA ,  FUJIMOTO SHINPEI ,  SATO YUICHI ,  ISHII KIYOSHI ,  OWAKI KEIJI

IPC: C07D213/66 ,  A61K31/44 ,  A61K31/5377 ,  A61P3/10

Abstract: 【課題】経口投与した際の吸収性が良好で、安全性の高い血糖低下剤であり、AGE生成反応のインヒビターとして有用な化合物、およびその製造方法の提供。【解決手段】ピリドキサールと1−アミノー3−プロピルグアニジンヨウ化水素酸塩、4−メチル−S−メチルイソチオセミカルバジドヨウ化水素酸塩、3−メチルイソセミカルバジド塩酸塩、モルホリン−4−カルボキシイミドヒドラジドヨウ化水素酸塩のいずれかを反応させることによる、次式(V)で表されるピリジン誘導体のアミノ基を変換した構造を有する、ピリドキサール・アミノグアニジン誘導体またはそれらの塩。【選択図】なし

Abstract translation: 要解决的问题：提供口服吸收性好的化合物，作为高安全性的降血糖药，可用作AGE形成反应的抑制剂及其制备方法。解决方案：制备吡哆醛/氨基胍衍生物的方法及其制备方法 具有与另一基团取代的式（Ⅴ）吡啶衍生物的氨基结构的盐包括使吡哆醛与1-氨基-3-丙基胍氢碘酸盐，4-甲基-S-甲基异硫代氨基脲氢碘酸盐，3-甲基异氨基脲盐酸盐和 吗啉-4-羧酰亚胺酰肼氢碘酸盐。

公开(公告)号：JP2002187889A

公开(公告)日：2002-07-05

申请号：JP2000386401

申请日：2000-12-20

Applicant: PERMACHEM ASIA LTD

Inventor： ISHII KIYOSHI ,  YOKOGOSHI KIYONORI

IPC: C07D401/04

Abstract: PROBLEM TO BE SOLVED: To provide an oxyquinolinecarboxylic acid anhydride usable as an antibacterial agent for medical use. SOLUTION: The oxyquinolinecarboxylic acid anhydride expressed by formula II is produced by dissolving oxyquinolinecarboxylic acid of formula I in an organic solvent and adding anhydrous hydrogen chloride to the solution. The organic solvent may be a solvent dissolving the compound of formula I or a mixture of the solvent dissolving the compound and a solvent scarcely dissolving the compound.

公开(公告)号：JPS58167513A

公开(公告)日：1983-10-03

申请号：JP4812982

申请日：1982-03-27

Applicant: GRELAN PHARMACEUTICAL CO ,  PERMACHEM ASIA LTD

Inventor： KIKAZAWA KAZUO ,  HIIRAGI MINEJI ,  KOUNO OSAMU ,  MISAKI NORIYUKI ,  UCHIDA KATSUYUKI ,  MURAYAMA YUU ,  ISHII KIYOSHI

IPC: C07D233/88 ,  A61K31/415 ,  A61P1/04

Abstract: PURPOSE:The titled remedy, containing 5-methylallantoin as an active constituent, and having a remedial effect on the peptic ulcer with low toxicity. CONSTITUTION:A remedy for peptic ulcer containing 5-methylallantoin of formulaIas an active constituent. The active constituent of formulaIis synthesized by reacting a urea compd. of formula II with an alpha-ketocarboxylic acid of formula III in the presence of a dehydrating agent, preferably an acidic catalyst at room temperature or under a little warming. An inorganic acid, e.g. hydrochloric or sulfuric acid, is used as the acidic catalyst. The melting point, etc. of the 5-methylallantoin of formulaIare not described in literature, and the structure thereof is determined by elementary analyses and measurement of various spectra with the estimated 211 deg.C melting point. In use as the titled remedy, the dosage form for the oral administration is a tablet, capsule, powder, etc. may be cited, and the daily dose of the active constituent is suitably 100mg-1g for an adult.

公开(公告)号：JP2008222630A

公开(公告)日：2008-09-25

申请号：JP2007062613

申请日：2007-03-12

Applicant: Permachem Asia Ltd ,  株式会社パーマケム・アジア

Inventor： OWAKI KEIJI ,  ISHII KIYOSHI ,  YOKOGOSHI KIYONORI

IPC: C07H19/056

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing ribavirin R-II type crystal which is assumed to be an effective ingredient in a ribavirin medicine.
SOLUTION: The manufacturing method comprises dissolving ribavirin in an organic solvent and a small amount of water followed by refluxing and subsequent recrystallization. Concretely, the ribavirin R-II type crystal is produced by dissolving 1 pt.wt. of ribavirin in a mixed solvent of at least 20 pts.wt. of a 3C or higher alcohol solvent with at most 25 wt.%, based on the alcohol solvent, of water followed by refluxing under heating, and subsequently cooling the mixed solvent down to 10°C or lower followed by filtration.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供在利巴韦林药物中假定为有效成分的利巴韦林R-II型晶体的制造方法。 解决方案：制造方法包括将有利溶剂中的利巴韦林溶解在有机溶剂和少量水中，然后回流并随后重结晶。 具体来说，利巴韦林R-II型晶体通过溶解1重量％ 的利巴韦林在至少20重量份的混合溶剂中 的基于醇溶剂的至多25重量％的3C或更高级的醇溶剂，然后在加热下回流，随后将混合溶剂冷却至10℃或更低，然后过滤。 版权所有（C）2008，JPO＆INPIT