公开(公告)号：DE3665578D1

公开(公告)日：1989-10-19

申请号：DE3665578

申请日：1986-06-13

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26 ,  C07C79/18

Abstract: A process for producing a dibromonitro compound represented by the general formulawherein R represents a hydrogen atom or a methyl group, which comprises condensing nitromethane with formaldehyde or acetaldehyde in the presence of an alkali, the amount of the aldehyde being at least 1.5 moles per mole of nitromethane; and thereafter without isolating the product, treating the reaction mixture with bromine to brominate the product.

公开(公告)号：FI862557A

公开(公告)日：1986-12-18

申请号：FI862557

申请日：1986-06-16

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26 ,  C07C

Abstract: A process for producing a dibromonitro compound represented by the general formulawherein R represents a hydrogen atom or a methyl group, which comprises condensing nitromethane with formaldehyde or acetaldehyde in the presence of an alkali, the amount of the aldehyde being at least 1.5 moles per mole of nitromethane; and thereafter without isolating the product, treating the reaction mixture with bromine to brominate the product.

公开(公告)号：EP0206173A1

公开(公告)日：1986-12-30

申请号：EP86108117

申请日：1986-06-13

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26 ,  C07C79/18

CPC classification number: C07C201/12 ,  C07C201/16 ,  C07C205/26

Abstract: A process for producing a dibromonitro compound represented by the general formula

wherein R represents a hydrogen atom or a methyl group, which comprises condensing nitromethane with formaldehyde or acetaldehyde in the presence of an alkali, the amount of the aldehyde being at least 1.5 moles per mole of nitromethane; and thereafter without isolating the product, treating the reaction mixture with bromine to brominate the product.

Abstract translation: 一种由通式表示的二溴硝基化合物的制备方法，其中R表示氢原子或甲基，该方法包括在碱的存在下将硝基甲烷与甲醛或乙醛缩合，醛的量为每摩尔至少1.5摩尔 硝基甲烷; 然后不分离产物，用溴处理反应混合物以溴化产物。

公开(公告)号：FI862557A0

公开(公告)日：1986-06-16

申请号：FI862557

申请日：1986-06-16

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26 ,  C07C

Abstract: A process for producing a dibromonitro compound represented by the general formulawherein R represents a hydrogen atom or a methyl group, which comprises condensing nitromethane with formaldehyde or acetaldehyde in the presence of an alkali, the amount of the aldehyde being at least 1.5 moles per mole of nitromethane; and thereafter without isolating the product, treating the reaction mixture with bromine to brominate the product.

公开(公告)号：FI85135B

公开(公告)日：1991-11-29

申请号：FI862557

申请日：1986-06-16

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26

Abstract: A process for producing a dibromonitro compound represented by the general formulawherein R represents a hydrogen atom or a methyl group, which comprises condensing nitromethane with formaldehyde or acetaldehyde in the presence of an alkali, the amount of the aldehyde being at least 1.5 moles per mole of nitromethane; and thereafter without isolating the product, treating the reaction mixture with bromine to brominate the product.

公开(公告)号：FI85135C

公开(公告)日：1992-03-10

申请号：FI862557

申请日：1986-06-16

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26

公开(公告)号：CA1267158A

公开(公告)日：1990-03-27

申请号：CA511512

申请日：1986-06-13

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26 ,  C07C79/18

Abstract: A process for producing a dibromonitro compound represented by the general formula (I) wherein R represents a hydrogen atom or a methyl group, which comprises condensing nitromethane with formaldehyde or acetaldehyde in the presence of an alkali, the amount of the aldehyde being at least 1.5 moles per mole of nitromethane; and thereafter without isolating the product, treating the reaction mixture with bromine to brominate the product.

公开(公告)号：AT46320T

公开(公告)日：1989-09-15

申请号：AT86108117

申请日：1986-06-13

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI MIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26 ,  C07C79/18

Abstract: A process for producing a dibromonitro compound represented by the general formulawherein R represents a hydrogen atom or a methyl group, which comprises condensing nitromethane with formaldehyde or acetaldehyde in the presence of an alkali, the amount of the aldehyde being at least 1.5 moles per mole of nitromethane; and thereafter without isolating the product, treating the reaction mixture with bromine to brominate the product.

公开(公告)号：JPS6028922A

公开(公告)日：1985-02-14

申请号：JP13674783

申请日：1983-07-28

Applicant: GRELAN PHARMACEUTICAL CO ,  PERMACHEM ASIA LTD

Inventor： KIKAZAWA KAZUO ,  HIIRAGI MINEJI ,  SAWABE TAKASHI ,  WAKIZAKA KIKUO ,  MURAYAMA YUU ,  ISHII KIYOSHI

IPC: A61K8/49 ,  A61K8/40 ,  A61K9/06 ,  A61K31/415 ,  A61P17/00 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q19/00 ,  C07D233/88

Abstract: PURPOSE:An external preparation for the skin useful for remedying and preventing skin diseases such as humid tetter, acne, wound, etc., protecting the skin as a drug, quasi-drug, or cosmetic, containing 5-methylallantoin. CONSTITUTION:An external preparation for the skin containing 5-methylallantoin as an active ingredient. The external preparation for the skin has remedy promoting action on damaged parts such as wound, ulcer, burn, etc., astringent action, and covering action. It is useful for remedying erosion of the skin or mucosa, ulcer, and skin diseases such as humid tetter, etc., and used as a drug or quasi-drug having the above-mentioned medicinal effects. Since the active ingredient has no irritation to the skin, it may be blended with cosmetic, it prevents skin irritations of lips and chapped skin, is expected to have soft feeling in use, to make people undergo rejuvenation, etc. An amount of the active ingredient added is 0.01-20wt% based on the whole amount of pharmaceutical preparation, preferably 0.01-5wt% in the case of cosmetic, and 1-20wt% in the case of quasi-drug.

公开(公告)号：JPS61289063A

公开(公告)日：1986-12-19

申请号：JP13003285

申请日：1985-06-17

Applicant: PERMACHEM ASIA LTD

Inventor： WATANABE MICHIO ,  ISHII KIYOSHI ,  NAMIKI YOSHIE ,  FUKUDA TAKESHI

IPC: C07C67/00 ,  C07C201/00 ,  C07C201/12 ,  C07C205/26

Abstract: PURPOSE:To obtain the titled substance useful as pharmaceuticals and disinfectants, etc., safely in high yield and purity, by using formaldehyde or acetaldehyde as a raw material at a specific ratio to nitromethane, condensing the raw materials using an alkali, and brominating the product with bromine without separating from the reaction system. CONSTITUTION:1mol of nitromethane and >=1.5mol of formaldehyde or acetaldehyde are dissolved in a solvent and condensed with an alkali such as sodium hydroxide, potassium methoxide, etc. The condensation product is, without separating from the reaction system, brominated with bromine to obtain the compound of formula (R is H or methyl). The solvent used in the above reaction is water, lower alcohol, toluene, etc., and the condensation reaction is carried out at -20-+120 deg.C. Bromine may be used as it is in the bromination reaction, however, it is preferable to dissolve bromine in a solvent and add the solution dropwise to the reaction system. The amount of bromine is generally >=2 equivalent based on nitromethane.