公开(公告)号：CZ20031290A3

公开(公告)日：2003-08-13

申请号：CZ20031290

申请日：2001-10-11

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN LUC ,  ORTUNO JEAN-CLAUDE ,  LEVENS NIGEL ,  CHAMORRO SUSANA ,  BOUTIN JEAN ALBERT

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/55 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  A61K31/381 ,  A61K31/341 ,  A61P9/00 ,  A61P25/00 ,  A61P1/00

Abstract: A compound of formula (I): wherein: R1 and R2 represent hydrogen or a group as defined in the description, R3 represents hydrogen or alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, R4 represents a group of formula (II): wherein W and B are as defined in the description, R5 represents hydrogen or alkyl, A represents a group selected from -A2-, -A1-A2-, -A2-A1- and -A1-A2-A1-, V is as defined in the description.

公开(公告)号：NZ519610A

公开(公告)日：2003-05-30

申请号：NZ51961002

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  C07D295/18 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D295/13 ,  C07C233/10

Abstract: Described are compounds of formula (I), processes for their preparation and pharmaceutical compositions comprising compounds of formula (I) for use in treating diabetes, wherein; A represents a saturated carbon ring having from 4 to 8 ring members, optionally substituted by one or more linear or branched (C1-C6)alkyl groups, R1 and R4, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)acyl group, R2 and R3, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)alkyl group, R5 and R6, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)alkyl group, or R5 and R6 together with the nitrogen atom carrying thrm, form a nitrogen containing heterocycle optionally substituted by one or more identical or different groups selected from cyano, CO2R7, nitro, CONR8aR8b (wherein R8a and R8b, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)alkyl group or R8a and R8b together form a nitrogen-containing heterocycle), S(O)nR9 (wherein n represents 1, 2 or 3, and R9 represents a hydrogen atom, a linear or branched (C1-C6)alkyl group or an aryl group) and PO3R10aR10b (wherein R10a and R10b, which may be identical or different, each represents a hydrogen atom or a linear or branched (C1-C6)alkyl group).

公开(公告)号：CZ20022119A3

公开(公告)日：2003-02-12

申请号：CZ20022119

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：ZA200203867B

公开(公告)日：2003-01-02

申请号：ZA200203867

申请日：2002-05-15

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: A61K31/40 ,  A61K31/426 ,  C07D295/10 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D ,  A61K

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：FR2826003A1

公开(公告)日：2002-12-20

申请号：FR0107934

申请日：2001-06-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN MARIE ,  LEVENS NIGEL ,  HUSSON ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D207/12

Abstract: Cyclic alpha- amino gamma-hydroxy amides (I), their stereoisomers, and acid addition salts are new. Cyclic alpha- amino gamma-hydroxy amides (I), their stereoisomers, and acid addition salts are new. ring A = 4-8 membered saturated C ring that may be substituted by one or more 1-6C alkyl groups; R1 and R4 = H or 1-6C acyl; R2 and R3 = H or 1-6C alkyl; R5 and R6 = H, 1-6C alkyl, or together with the N atom form a saturated mono- or bicyclic nitrogen heterocycle having 1-3 heteroatoms (additional heteroatoms being O, N, or S) optionally substituted by one or more groups CN, COOR7, COR7, NO2, CONR8aR8b, S(O)nR9, or PO3R10aR10b; R7 = H or 1-6C alkyl; R8a and R8b = H, 1-6C alkyl or together form a N heterocycle as defined; R9 = H, 1-6C alkyl, or phenyl, biphenyl, naphthyl, or tetrahydronaphthyl all these aryl groups being optionally substituted by halogen, 1-6C alkyl or alkoxy, OH, 1-6C polyhalolalkyl, NO2, or 1 or 2 C alkylene dioxy; R10a and R10b = H or 1-6C alkyl; n = 1, 2, or 3.

公开(公告)号：AU4065402A

公开(公告)日：2002-11-21

申请号：AU4065402

申请日：2002-05-15

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BOULANGER MICHELLE ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  LEVENS NIGEL ,  BENOIST ALAIN ,  PORTEVIN BERNARD

IPC: C07D295/10 ,  A61K31/40 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D295/192 ,  C07D277/22 ,  C07D277/30 ,  A61K31/401

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：NO20022285L

公开(公告)日：2002-11-18

申请号：NO20022285

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: A61K31/40 ,  C07D295/10 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：NO20022285D0

公开(公告)日：2002-05-14

申请号：NO20022285

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: A61K31/40 ,  C07D295/10 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：AU1063202A

公开(公告)日：2002-04-22

申请号：AU1063202

申请日：2001-10-11

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  LEVENS NIGEL ,  CHAMORRO SUSANA ,  BOUTIN JEAN ALBERT

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/55 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12

Abstract: A compound of formula (I): wherein: R1 and R2 represent hydrogen or a group as defined in the description, R3 represents hydrogen or alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, R4 represents a group of formula (II): wherein W and B are as defined in the description, R5 represents hydrogen or alkyl, A represents a group selected from -A2-, -A1-A2-, -A2-A1- and -A1-A2-A1-, V is as defined in the description.

公开(公告)号：AU2003226860B9

公开(公告)日：2008-08-14

申请号：AU2003226860

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  BAUT GUILLAUME LE ,  DUFLOS MURIEL ,  HUSSON-ROBERT BERNADETTE ,  DASSONVILLE ALEXANDRA ,  PFEIFFER BRUNO ,  LEVENS NIGEL ,  BRETECHE ANNE

IPC: C07C50/28 ,  A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.