公开(公告)号：BR0016568A

公开(公告)日：2002-10-01

申请号：BR0016568

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENNEE ,  BAUT GUILLAUME LE ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14

Abstract: Compound of formula (I):wherein:Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl,A represents a bond or linear or branched (C1-C6)alkylene,its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.

公开(公告)号：AU2003226860B2

公开(公告)日：2008-06-26

申请号：AU2003226860

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  BAUT GUILLAUME LE ,  DUFLOS MURIEL ,  HUSSON-ROBERT BERNADETTE ,  DASSONVILLE ALEXANDRA ,  PFEIFFER BRUNO ,  LEVENS NIGEL ,  BRETECHE ANNE

IPC: C07C50/28 ,  A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：NO20043532A

公开(公告)日：2004-08-24

申请号：NO20043532

申请日：2004-08-24

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  DUFLOS MURIEL ,  PFEIFFER BRUNO ,  DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  BAUT GUILLAUME LE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

CPC classification number: C07D213/50 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C50/28 ,  C07C49/245

公开(公告)号：NO20023023A

公开(公告)日：2002-06-21

申请号：NO20023023

申请日：2002-06-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  BAUT GUILLAUME LE ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14 ,  A61K31/385

CPC classification number: C07D409/14 ,  C07D417/14

公开(公告)号：AU2689001A

公开(公告)日：2001-07-03

申请号：AU2689001

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  BAUT GUILLAUME LE ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14

Abstract: Compound of formula (I):wherein:Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl,A represents a bond or linear or branched (C1-C6)alkylene,its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.

公开(公告)号：AU2003226860B9

公开(公告)日：2008-08-14

申请号：AU2003226860

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  BAUT GUILLAUME LE ,  DUFLOS MURIEL ,  HUSSON-ROBERT BERNADETTE ,  DASSONVILLE ALEXANDRA ,  PFEIFFER BRUNO ,  LEVENS NIGEL ,  BRETECHE ANNE

IPC: C07C50/28 ,  A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：ZA200405446B

公开(公告)日：2005-07-08

申请号：ZA200405446

申请日：2004-07-08

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFRIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50 ,  C07C ,  C07D ,  A61K ,  A61P

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：BR0307465A

公开(公告)日：2004-11-09

申请号：BR0307465

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：NO20043532L

公开(公告)日：2004-08-24

申请号：NO20043532

申请日：2004-08-24

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  DUFLOS MURIEL ,  PFEIFFER BRUNO ,  DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  BAUT GUILLAUME LE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：NO20023023D0

公开(公告)日：2002-06-21

申请号：NO20023023

申请日：2002-06-21

Applicant: SERVIER LAB

Inventor： DUFLOS MURIEL ,  ROBERT JEAN-MICHEL ,  NOURRISSON MARIE-RENEE ,  BAUT GUILLAUME LE ,  CAIGNARD DANIEL-HENRI ,  BIZOT-ESPIARD JEAN-GUY ,  RENARD PIERRE

IPC: C07D213/74 ,  A61K31/427 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/506 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  C07D409/14 ,  C07D417/14 ,  C07D

Abstract: Compound of formula (I):wherein:Het1 and Het2, which may be identical or different, each represents an optionally substituted pyridyl,A represents a bond or linear or branched (C1-C6)alkylene,its optical isomers, where they exist, and addition salts thereof with a pharmaceutically acceptable acid.