公开(公告)号：WO2008049997A8

公开(公告)日：2009-05-22

申请号：PCT/FR2007001708

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/4045

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): in which: R1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; medicaments.

Abstract translation: 式（I）化合物：其中：R1是烷基，环烷基或环烷基烷基，R2和R3与带有它们的氮原子一起形成包含5至8个环成员的杂环，n是2至6 ; 药物。

公开(公告)号：WO2008049996A3

公开(公告)日：2008-06-19

申请号：PCT/FR2007001707

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

CPC classification number: C07D209/42

Abstract: The invention relates to compounds of formula (I), in which: R is an alkyl, cycloalkyl or cycloalkylalkyl group, R is a linear or branched (C 1 -C 6 ) alkyl group, and n is 1 to 6, and to the use thereof for the treatment of disorders in the melatoninergic system, such as sleep disorders, stress, anxiety, cardiovascular pathologies, etc..

Abstract translation: 本发明涉及式（I）化合物，其中：R是烷基，环烷基或环烷基烷基，R是直链或支链（C 1 -C 6 - ）烷基，n为1至6，以及其用于治疗褪黑激素系统中的疾病的用途，例如睡眠障碍，应激，焦虑，心血管病变等。

公开(公告)号：WO2008049997A3

公开(公告)日：2008-09-12

申请号：PCT/FR2007001708

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BADONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BADONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/4045

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): in which: R 1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R 2 and R 3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; medicaments.

Abstract translation: 式（I）化合物：其中：R 1是烷基，环烷基或环烷基烷基，R 2和R 3， 带有它们的氮原子，包含5至8个环成员的杂环，n为2至6; 药物。

公开(公告)号：UA91646C2

公开(公告)日：2010-08-10

申请号：UAA200904633

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P3/04 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

公开(公告)号：MA30795B1

公开(公告)日：2009-10-01

申请号：MA31791

申请日：2009-04-16

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  A61P9/00

Abstract: COMPOSÉS DE FORMULE (I), DANS LAQUELLE R1 REPRÉSENTE UN GROUPEMENT ALKYLE, CYCLOALKYLE, OU CYCLOALKYLALKYLE; R2 REPRÉSENTE UN GROUPEMENT ALKYLE (C1-C6) LINÉAIRE OU RAMIFIÉ; ET N REPRÉSENTE 1 À 6, ET LEUR UTILISATION POUR TRAITER LES TROUBLES DU SYSTÈME MÉLATONINERGIQUE TELS QUE LES TROUBLES DU SOMMEIL, LE STRESS, L'ANXIÉTÉ, LES PATHOLOGIES CARDIOVASCULAIRES, ETC.

公开(公告)号：AU2003226860B9

公开(公告)日：2008-08-14

申请号：AU2003226860

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  BAUT GUILLAUME LE ,  DUFLOS MURIEL ,  HUSSON-ROBERT BERNADETTE ,  DASSONVILLE ALEXANDRA ,  PFEIFFER BRUNO ,  LEVENS NIGEL ,  BRETECHE ANNE

IPC: C07C50/28 ,  A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：UA79448C2

公开(公告)日：2007-06-25

申请号：UA20040907252

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  LE BAUT GUILLAUME ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/00 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: The invention concerns a compound of formula (I), wherein: R1 and R2, identical or different, represent each a hydrogen atom or an acyl or alkyl group; Ar represents an aryl or heteroaryl group; A represents a group selected from formula (II); R4 represents a hydrogen atom or an alkyl group; R5 represents a hydrogen atom or a group selected among alkyl, aryl and heteroaryl; R3 represents an aryl, heteroaryl, dicyclopropylmethyl or benzhydryl group, or A-R3 represents an optionally substituted naphthyl group, excluding 2,5-dihydioxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone, and 2,5-dihydroxy-3 (2-naphthyl)-6-phenyl-1,4-benzoquinone. The inventive compound is useful for preparing medicines.

公开(公告)号：ZA200405446B

公开(公告)日：2005-07-08

申请号：ZA200405446

申请日：2004-07-08

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFRIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50 ,  C07C ,  C07D ,  A61K ,  A61P

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：BR0307465A

公开(公告)日：2004-11-09

申请号：BR0307465

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：NO20043532L

公开(公告)日：2004-08-24

申请号：NO20043532

申请日：2004-08-24

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  DUFLOS MURIEL ,  PFEIFFER BRUNO ,  DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  BAUT GUILLAUME LE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.