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公开(公告)号：AU2007233320B2
公开(公告)日：2013-12-12
申请号：AU2007233320
申请日：2007-04-04
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： TODD JOHN , PUSKAS ROBERT , HELD DOUGLAS , GOIX PHILIPPE , LIVINGSTON RICHARD , WU ALAN
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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12.发明专利
公开(公告)号：CA2648382A1
公开(公告)日：2008-04-24
申请号：CA2648382
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： TODD JOHN , PUSKAS ROBERT , GOIX PHILIPPE , LIVINGSTON RICHARD , HELD DOUGLAS
Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused lase r beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomola r, or lower. The methods, kits, and compositions also allow the determination o f concentration over a wide range, e.g., 7-log range, without need for sample dilution.
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公开(公告)号：AU2016204877A1
公开(公告)日：2016-07-28
申请号：AU2016204877
申请日：2016-07-13
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin. WO 2007/114947 PCT/US2007/008506 30 3 7 0 630 5 Figure 1A
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公开(公告)号：ES2550004T3
公开(公告)日：2015-11-03
申请号：ES11169710
申请日：2007-04-04
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN H
Abstract: Un método para determinar una enfermedad cardiovascular en un individuo que comprende: (a) medir la concentración en suero o plasma de la troponina cardiaca a partir de una muestra de sangre del individuo; (b) comparar la concentración medida a una concentración umbral predeterminada que representa la concentración de percentil 99º de la troponina cardiaca en un grupo de individuos normales con un coeficiente de variación (CV) correspondiente del 10% o menos, en donde la concentración umbral es menos de 10 pg/mL; (c) determinar al menos uno de los siguientes en el individuo cuando la concentración de troponina cardiaca es mayor que la concentración umbral: daño cardiaco, daño miocárdico, un evento cardiaco anterior y cardiotoxicidad.
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15.发明专利
公开(公告)号：AU2013219225A1
公开(公告)日：2013-10-03
申请号：AU2013219225
申请日：2013-08-23
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Abstract: METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 5OF THE DISCLOSURE Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution. WO 2008/048371 PCT/US2007/008394 Figur IA1 308 307 306 305 Figure 1A
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Patent Agency Ranking
公开(公告)号：CA3086149A1
公开(公告)日：2007-10-11
申请号：CA3086149
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN H
Abstract: ABSTRACT Methods for sensitive detection of cardiac troponin are described for diagnosis, prognosis, and determination of treatment in conditions that involve release of cardiac troponin. A method for determining cardiovascular health of an individual comprises measuring serum or plasma concentration of Cardiac Troponin I (cTnI) and/or Cardiac Troponin T (cTnT), determined by an assay with a cTnI or cTnT detection limit of less than 10 pg/mL. Concentrations are compared to a predetermined threshold representing the 99th percentile of cTnI or cTnT with a corresponding coefficient variation of 10% or less in normal individuals. Cardiac damage or disease is determined when sample concentration is above threshold. A method of evaluating an individual for a previous cardiac event comprises detecting a concentration of cTnI in a sample and determining a previous cardiac event when cTnI level is greater than 7 pg/mL. Date Recue/Date Received 2020-07-08
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公开(公告)号：CA2648385A1
公开(公告)日：2007-10-11
申请号：CA2648385
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： TODD JOHN , PUSKAS ROBERT , GOIX PHILIPPE , LIVINGSTON RICHARD , HELD DOUGLAS
IPC: G01N33/53
Abstract: The invention provides methods for diagnosing, predicting or prognosing acute myocardial infarction in an individual based on the sensitive detection of cardiac troponin.
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公开(公告)号：AU2007233320A1
公开(公告)日：2007-10-11
申请号：AU2007233320
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： TODD JOHN , PUSKAS ROBERT , HELD DOUGLAS , GOIX PHILIPPE , LIVINGSTON RICHARD
IPC: G01N33/53
Abstract: The invention provides methods for diagnosing, predicting or prognosing acute myocardial infarction in an individual based on the sensitive detection of cardiac troponin.
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19.发明申请METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开高灵敏度分析标记物和检测分子的方法和组合物
公开(公告)号：WO2008048371A9
公开(公告)日：2008-11-27
申请号：PCT/US2007008394
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
Abstract translation: 公开了用于单个生物分子的荧光检测的方法，试剂盒和组合物，例如， 使用高度敏感的荧光染料和具有一个询问空间的流动池用于通过聚焦激光束进行照射。 这些方法，试剂盒和组合物可用于确定样品中分子浓度达到1飞摩尔，1摩尔或更低的水平。 该方法，试剂盒和组合物还允许在很宽的范围，例如7个对数范围内测定浓度，而不需要样品稀释。
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公开(公告)号：WO2007114947A2
公开(公告)日：2007-10-11
申请号：PCT/US2007008506
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
IPC: G06F15/00
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。
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