公开(公告)号：DE60124747T2

公开(公告)日：2007-03-29

申请号：DE60124747

申请日：2001-09-26

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CHARMOT DOMINIQUE ,  CHANG TING ,  LI YUNXIAO ,  HUEFNER PETER

IPC: C07D231/10 ,  C08F2/38 ,  C07C337/02 ,  C07C337/04 ,  C07C337/08 ,  C07D285/125 ,  C08F2/00 ,  C08F4/00 ,  C08F4/04 ,  C08F8/00 ,  C08F293/00

Abstract: A method of free radical polymerization and for cleaving a thio group from the resulting polymer is provided. The method comprises forming a mixture of one or more monomers, at least one free radical source and a control agent, wherein the control agent comprises a thio moiety. The mixture is polymerized, and the resulting polymer is mixed with a free radical source, and optionally an addition fragmentation agent under cleavage conditions. The thio moiety on the polymer is replaced with a group of interest.

公开(公告)号：AT346099T

公开(公告)日：2006-12-15

申请号：AT01973529

申请日：2001-09-26

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CHARMOT DOMINIQUE ,  CHANG HAN TING ,  LI YUNXIAO ,  HUEFNER PETER

IPC: C07D231/10 ,  C07C337/02 ,  C07C337/04 ,  C07D285/125 ,  C08F2/00 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04 ,  C08F8/00 ,  C08F293/00 ,  C07C337/08

Abstract: A method of free radical polymerization and for cleaving a thio group from the resulting polymer is provided. The method comprises forming a mixture of one or more monomers, at least one free radical source and a control agent, wherein the control agent comprises a thio moiety. The mixture is polymerized, and the resulting polymer is mixed with a free radical source, and optionally an addition fragmentation agent under cleavage conditions. The thio moiety on the polymer is replaced with a group of interest.

公开(公告)号：DE60112129T2

公开(公告)日：2006-01-12

申请号：DE60112129

申请日：2001-09-26

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CHARMOT DOMINIQUE ,  CHANG TING

IPC: C08F2/00 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04

Abstract: Control agents that have a nitrogen-nitrogen bond in a cyclic ring covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization without a bimodal molecular weight distribution at high monomer conversions. These control agents provide superior properties for the production of block polymers having narrow molecular weight distributions.

公开(公告)号：AU9653001A

公开(公告)日：2002-04-15

申请号：AU9653001

申请日：2001-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： LIU MINGJUN ,  NIELSEN RALPH B ,  CHARMOT DOMINIQUE ,  HADJUK DAMIAN ,  FRECHET JEAN M J ,  KHOSDEL EZAT

IPC: C08F2/38 ,  C08F4/00 ,  C08F293/00 ,  C08F297/00 ,  C08F297/02 ,  C08F297/06

Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.

公开(公告)号：CA2377739A1

公开(公告)日：2001-01-11

申请号：CA2377739

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MANSKY PAUL ,  BENOIT DIDIER ,  KLAERNER GERRIT ,  CHARMOT DOMINIQUE ,  NIELSEN RALPH B ,  JANDELEIT BERND ,  MAZZOLA LAURA T

IPC: C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F292/00 ,  G01N33/48 ,  C12Q1/68

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which compris e a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled fr ee radical polymerization techniques which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

公开(公告)号：DE60112129D1

公开(公告)日：2005-08-25

申请号：DE60112129

申请日：2001-09-26

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CHARMOT DOMINIQUE ,  CHANG TING

IPC: C08F2/00 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04

Abstract: Control agents that have a nitrogen-nitrogen bond in a cyclic ring covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization without a bimodal molecular weight distribution at high monomer conversions. These control agents provide superior properties for the production of block polymers having narrow molecular weight distributions.

公开(公告)号：AT299897T

公开(公告)日：2005-08-15

申请号：AT01973533

申请日：2001-09-26

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CHARMOT DOMINIQUE ,  CHANG HAN TING

IPC: C08F2/00 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04

Abstract: Control agents that have a nitrogen-nitrogen bond in a cyclic ring covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization without a bimodal molecular weight distribution at high monomer conversions. These control agents provide superior properties for the production of block polymers having narrow molecular weight distributions.

公开(公告)号：DE60124747D1

公开(公告)日：2007-01-04

申请号：DE60124747

申请日：2001-09-26

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CHARMOT DOMINIQUE ,  CHANG TING ,  LI YUNXIAO ,  HUEFNER PETER

IPC: C07D231/10 ,  C08F2/38 ,  C07C337/02 ,  C07C337/04 ,  C07C337/08 ,  C07D285/125 ,  C08F2/00 ,  C08F4/00 ,  C08F4/04 ,  C08F8/00 ,  C08F293/00

Abstract: A method of free radical polymerization and for cleaving a thio group from the resulting polymer is provided. The method comprises forming a mixture of one or more monomers, at least one free radical source and a control agent, wherein the control agent comprises a thio moiety. The mixture is polymerized, and the resulting polymer is mixed with a free radical source, and optionally an addition fragmentation agent under cleavage conditions. The thio moiety on the polymer is replaced with a group of interest.

公开(公告)号：DE60027309T2

公开(公告)日：2006-08-31

申请号：DE60027309

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  NIELSEN B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA T

IPC: C08F292/00 ,  C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  C12Q1/68 ,  G01N27/447 ,  G01N33/48 ,  G01N33/543

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

公开(公告)号：DE60027309D1

公开(公告)日：2006-05-24

申请号：DE60027309

申请日：2000-07-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KLAERNER GERRIT ,  NIELSEN B ,  MANSKY PAUL ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE ,  JANDELEIT BERND ,  MAZZOLA T

IPC: C08F292/00 ,  C08F4/00 ,  C08F220/54 ,  C08F220/58 ,  C12Q1/68 ,  G01N27/447 ,  G01N33/48 ,  G01N33/543

Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.