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公开(公告)号：DE60027309T2
公开(公告)日：2006-08-31
申请号：DE60027309
申请日：2000-07-03
Applicant: SYMYX TECHNOLOGIES INC
Inventor： KLAERNER GERRIT , NIELSEN B , MANSKY PAUL , BENOIT DIDIER , CHARMOT DOMINIQUE , JANDELEIT BERND , MAZZOLA T
IPC: C08F292/00 , C08F4/00 , C08F220/54 , C08F220/58 , C12Q1/68 , G01N27/447 , G01N33/48 , G01N33/543
Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
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公开(公告)号：DE60027309D1
公开(公告)日：2006-05-24
申请号：DE60027309
申请日：2000-07-03
Applicant: SYMYX TECHNOLOGIES INC
Inventor： KLAERNER GERRIT , NIELSEN B , MANSKY PAUL , BENOIT DIDIER , CHARMOT DOMINIQUE , JANDELEIT BERND , MAZZOLA T
IPC: C08F292/00 , C08F4/00 , C08F220/54 , C08F220/58 , C12Q1/68 , G01N27/447 , G01N33/48 , G01N33/543
Abstract: Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
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公开(公告)号：DE60106943D1
公开(公告)日：2004-12-09
申请号：DE60106943
申请日：2001-08-16
Applicant: BASF AG , SYMYX TECHNOLOGIES INC
Inventor： SCHROF WOLFGANG , SEUFERT MICHAEL , HEGER ROBERT , IDEN RUEDIGER , HORN DIETER , KOLTZENBURG SEBASTIAN , NIELSEN B , CARLSON ERIC , CHANG HAN-TING , PETRO MIROSLAV , KUEBLER SIGRID
IPC: B82B3/00 , C08F2/00 , C08F212/08 , B01J19/00
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Patent Agency Ranking
公开(公告)号：DE60003913T2
公开(公告)日：2004-02-05
申请号：DE60003913
申请日：2000-05-05
Applicant: SYMYX TECHNOLOGIES INC
IPC: B01J19/00 , C40B50/02 , G05B19/042 , G05B19/414
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公开(公告)号：DE60003913D1
公开(公告)日：2003-08-21
申请号：DE60003913
申请日：2000-05-05
Applicant: SYMYX TECHNOLOGIES INC
IPC: B01J19/00 , C40B50/02 , G05B19/042 , G05B19/414
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公开(公告)号：DE69908336T2
公开(公告)日：2003-11-27
申请号：DE69908336
申请日：1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor： TURNER HOWARD , DALES CAMERON , VAN ERDEN LYNN , VAN BEEK A , HAJDUK A , NIELSEN B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号：DE69908336D1
公开(公告)日：2003-07-03
申请号：DE69908336
申请日：1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor： TURNER HOWARD , DALES CAMERON , VAN ERDEN LYNN , VAN BEEK A , HAJDUK A , NIELSEN B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号：DE60106943T2
公开(公告)日：2005-05-04
申请号：DE60106943
申请日：2001-08-16
Applicant: BASF AG , SYMYX TECHNOLOGIES INC
Inventor： SCHROF WOLFGANG , SEUFERT MICHAEL , HEGER ROBERT , IDEN RUEDIGER , HORN DIETER , KOLTZENBURG SEBASTIAN , NIELSEN B , CARLSON ERIC , CHANG HAN-TING , PETRO MIROSLAV , KUEBLER SIGRID
IPC: B82B3/00 , C08F2/00 , C08F212/08 , B01J19/00
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