公开(公告)号：CA2527935C

公开(公告)日：2008-02-12

申请号：CA2527935

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： NIELSEN RALPH B ,  BENNETT JAMES ,  KUEBLER SIGRID C ,  PETRO MIROSLAV ,  SAFIR ADAM ,  CARLSON ERIC ,  FRECHET JEAN M J ,  DALES G CAMERON ,  LEE THOMAS S

IPC: G01N35/10

Abstract: A method for characterizing a polymer sample that includes the steps of withdrawing a polymer sample from a sample container into an injection probe of an auto- sampler where the probe is heated to maintain the withdrawn sample at a temperature of not less than about 75 degrees Celsius while resident in the probe. The heated injection probe resides in a first environment maintained at about ambient temperature while withdrawing the polymer sample. The method further includes loading at least a portion of the withdrawn sample into an injection port or a loading port of a liquid chromatography system where the injection port or loading port is adaptable for fluid communication with a chromatographic column. The chromatographic column resides in a heated second environment maintained at a temperature of not less than about 75 degrees Celsius. The loaded sample is injected into a mobile phase of the liquid chromatography system. The sample is maintained at a temperature but not les s than about 75 degrees Celsius during a period of time including from when the sample is withdrawn from the sample container to when the sample is within the heated second environment. The injected sample is chromatographically separated and a property of the sample or a composition thereof is detected.

公开(公告)号：DE60106943T2

公开(公告)日：2005-05-04

申请号：DE60106943

申请日：2001-08-16

Applicant: BASF AG ,  SYMYX TECHNOLOGIES INC

Inventor： SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  HEGER ROBERT ,  IDEN RUEDIGER ,  HORN DIETER ,  KOLTZENBURG SEBASTIAN ,  NIELSEN B ,  CARLSON ERIC ,  CHANG HAN-TING ,  PETRO MIROSLAV ,  KUEBLER SIGRID

IPC: B82B3/00 ,  C08F2/00 ,  C08F212/08 ,  B01J19/00

公开(公告)号：AU2002316372A1

公开(公告)日：2003-01-08

申请号：AU2002316372

申请日：2002-06-24

Applicant: SYMYX TECHNOLOGIES INC

Inventor： NIELSEN RALPH B ,  PETRO MIROSLAV ,  REGAN JACQUELINE M

IPC: G01N30/46 ,  G01N30/88 ,  G01N30/89 ,  G01N33/50 ,  G01N33/558 ,  G01N33/543 ,  G01N33/38 ,  G01N33/36 ,  G01N33/44 ,  G01N33/46 ,  G01N35/08 ,  G01N33/20 ,  G01N33/02

Abstract: Methods and apparatus for the evaluation of interactions between substances using inverse chromatography are disclosed. Preferably, interactions are evaluated between a liquid test sample and a solid phase comprising a receptor in the presence of a liquid carrier. Preferably, one of the modifying agent or receptor are members of a combinatorial library.

公开(公告)号：CA2321376A1

公开(公告)日：2001-04-01

申请号：CA2321376

申请日：2000-09-28

Applicant: SYMYX TECHNOLOGIES INC

Inventor： PETRO MIROSLAV

IPC: B01D15/18 ,  B01D15/24 ,  C40B40/14 ,  G01N1/00 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/62 ,  G01N30/84 ,  G01N30/88 ,  G01N33/44 ,  G01N35/02 ,  G01N35/08 ,  G01N30/22

Abstract: High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine sequential, serial injection of a plurality of sample s into mobile-phases supplied in parallel to two or more chromatographic columns, such that staggered, parallel separation of the plurality of samples is effected. Because injecti on of samples is relatively fast as compared to separation, substantial efficiencies are gain ed with respect to overall sample throughput. The disclosed HPLC methods and systems are preferably applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials

公开(公告)号：WO0214391A2

公开(公告)日：2002-02-21

申请号：PCT/EP0109386

申请日：2001-08-14

Applicant: BASF AG ,  SYMYX TECHNOLOGIES INC

Inventor： HEGER ROBERT ,  SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  AUWETER HELMUT ,  MAECHTLE WALTER ,  IDEN RUEDIGER ,  HORN DIETER ,  NIELSEN RALPH B ,  CARLSON ERIC ,  CHANG HAN TING ,  KUEBLER SIGRID ,  PETRO MIROSLAV

IPC: B41J2/01 ,  B01F17/34 ,  B01F17/52 ,  C08F212/04 ,  C08F212/08 ,  C08F220/34 ,  C08F226/06 ,  C09B1/54 ,  C09B67/20 ,  C09B67/46 ,  C09D11/00 ,  C09D11/10 ,  C09D17/00 ,  C09D133/14 ,  C09D135/06 ,  C09D139/08 ,  C08F220/00

CPC classification number: B82Y30/00 ,  C08F212/04 ,  C08F220/34 ,  C09B67/0085 ,  C09D11/106 ,  C09D11/30 ,  C09D133/14 ,  C09D135/06 ,  C09D139/08

Abstract: Disclosed are random radical (co)polymers containing -20 to 50 mol% of styrene as component A, -15 to 35 mol% of acrylic acid as component B, and -15 to 60 mol% of dimethylaminoethylmethacrylate (DMAEM) or 4-vinyl pyridine as component C; and dispersion formulations containing said (co)polymer, a dye selected from the group consisting of a monoazo dye, a quinophtalone dye, an anthraquinone dye, optionally further assistants, and an aqueous system; solid solutions containing said (co)polmyer, a dye selected from the group consisting of a monoazo dye, a quinophthalone dye, an anthraquinone dye, optionally further assistants; and dyeing formulations and formulations of inks for ink-jets comprising said dispersion formulation and optionally conventional dyeing auxiliaries.

Abstract translation: 公开了含有作为组分A的苯乙烯-20至50mol％，作为组分B的丙烯酸-15至35mol％和甲基丙烯酸二甲基氨基乙酯（DMAEM）或4-乙烯基的-15至60mol％的无规自由基（共）聚合物 吡啶作为组分C; 和含有所述（共）聚合物的分散体制剂，选自单偶氮染料，喹诺酮染料，蒽醌染料，任选的其它辅助剂和水性体系的染料; 含有所述（共）聚偏聚物的固体溶液，选自单偶氮染料，喹酞酮染料，蒽醌染料，任选的其它辅助剂的染料; 以及用于包含所述分散体制剂和任选的常规染色助剂的喷墨的油墨的染色配方和配方。

公开(公告)号：WO2004079338A3

公开(公告)日：2004-12-29

申请号：PCT/US2004006054

申请日：2004-02-27

Applicant: SYMYX TECHNOLOGIES INC ,  CARLSON ERIC ,  PETRO MIROSLAV ,  NGUYEN SON HOAI

Inventor： CARLSON ERIC ,  PETRO MIROSLAV ,  NGUYEN SON HOAI

IPC: G01N20060101 ,  G01N1/00 ,  G01N13/00 ,  G01N33/15

CPC classification number: C40B40/04 ,  G01N33/15 ,  Y10T436/119163 ,  Y10T436/255

Abstract: Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling and evaluation of very small samples, and can be advantageously applied in connection with evaluation of drug candidates.

公开(公告)号：WO03021251A9

公开(公告)日：2003-10-16

申请号：PCT/US0227629

申请日：2002-08-28

Applicant: SYMYX TECHNOLOGIES INC ,  PETRO MIROSLAV ,  NGUYEN SON HOAI ,  CARLSON ERIC D

Inventor： PETRO MIROSLAV ,  NGUYEN SON HOAI ,  CARLSON ERIC D

IPC: B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  G01N30/02 ,  G01N30/20 ,  G01N30/32 ,  G01N30/46 ,  G01N30/86 ,  G01N33/44 ,  G01N30/88

CPC classification number: G01N30/463 ,  B01D15/1878 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01D15/424 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00389 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00736 ,  G01N30/02 ,  G01N30/20 ,  G01N30/46 ,  G01N30/461 ,  G01N30/8651 ,  G01N33/44 ,  G01N2030/027 ,  G01N2030/324 ,  G01N30/16

Abstract: Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).

Abstract translation: 公开了在综合的直接耦合的多维液相色谱系统中用于表征聚合物样品的方法和装置，并且在优选实施方案中，聚合物样品的文库。 第一和第二维度优选是高效液相色谱尺寸，例如，适于确定组合物的第一维度。 适用于流动相梯度洗脱色谱法，包括反相色谱法，吸附色谱法等），以及适用于测定分子量或粒度的第二维度（例如适用于尺寸排阻色谱法，包括凝胶渗透色谱法）。

公开(公告)号：WO0109204A9

公开(公告)日：2002-09-26

申请号：PCT/US0020850

申请日：2000-07-31

Applicant: SYMYX TECHNOLOGIES INC ,  KLAERNER GERRIT ,  PETRO MIROSLAV ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE

Inventor： KLAERNER GERRIT ,  PETRO MIROSLAV ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE

IPC: C08F2/38 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F220/56 ,  C08F293/00

CPC classification number: C08F220/58 ,  C08F220/54 ,  G01N27/44747 ,  G01N33/54353

Abstract: Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make them particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.

Abstract translation: 用活性型或半活性型自由基聚合制备优选用丙烯酰胺型单体制备的受控结构聚合物，其结构优选不是线性的，如星形，支化，接枝或超支化。 受控结构聚合物具有高重均分子量和低粘度，这使得它们在用于生物分子如DNA片段的可置换毛细管电泳分离介质中特别有用。

公开(公告)号：WO0109204A2

公开(公告)日：2001-02-08

申请号：PCT/US0020850

申请日：2000-07-31

Applicant: SYMYX TECHNOLOGIES INC ,  KLAERNER GERRIT ,  PETRO MIROSLAV ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE

Inventor： KLAERNER GERRIT ,  PETRO MIROSLAV ,  BENOIT DIDIER ,  CHARMOT DOMINIQUE

IPC: C08F2/38 ,  C08F220/54 ,  C08F220/58 ,  G01N27/447 ,  G01N33/543 ,  C08F20/00

CPC classification number: C08F220/58 ,  C08F220/54 ,  G01N27/44747 ,  G01N33/54353

Abstract: Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make them particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.

Abstract translation: 在活性型或半活性型自由基聚合中制备优选用丙烯酰胺型单体制备的受控结构聚合物，其结构优选不是直链的，如星形，支链，接枝或超分支。 受控的结构聚合物具有高重均分子量和低粘度，这使得它们在用于生物分子例如DNA片段的可更换毛细管电泳分离介质中特别有用。

公开(公告)号：WO0214377A3

公开(公告)日：2002-06-20

申请号：PCT/EP0109469

申请日：2001-08-16

Applicant: BASF AG ,  SYMYX TECHNOLOGIES INC

Inventor： SCHROF WOLFGANG ,  SEUFERT MICHAEL ,  HEGER ROBERT ,  IDEN RUEDIGER ,  HORN DIETER ,  KOLTZENBURG SEBASTIAN ,  NIELSEN RALPH B ,  CARLSON ERIC ,  CHANG HAN-TING ,  PETRO MIROSLAV ,  KUEBLER SIGRID

IPC: B82B3/00 ,  C08F2/00 ,  C08F212/08 ,  B01J19/00

CPC classification number: C08F2/00 ,  C08F212/08 ,  C08F220/06 ,  C08F226/06

Abstract: Disclosed is a method of making an array of n nanoparticular dispersion formulations, wherein said nanoparticular dispersion formulations each comprise -at least one nanodispersant, -at least one application media, -an active ingredient said method comprising the following steps: c) making said array of n nanoparticular dispersion formulations by c1) a parallelized solid solution route, or c2) a parallelized general precipitation route, or c3) a parallelized reactive precipitation route, d) parallelized, rapid serial or semi-parallel characterizing of said obtained n nanoparticular dispersion formulations; an array of at least 8 different nanoparticular dispersion formulations; a method of making an array of m nanodipersants by a parallel polymerization process; an array of at least 8 different nanodispersants; a method of making an array of n solid solutions by a parallelized solid solution route; and an array of at least 8 different.

Abstract translation: 公开了制备n个纳米颗粒分散体制剂阵列的方法，其中所述纳米颗粒分散体制剂各自包含至少一个纳米分散剂 - 至少一种施用介质 - 活性成分，所述方法包括以下步骤：c）制备所述阵列 通过c1）平行化固溶体途径，或c2）平行化的一般沉淀途径，或c3）平行化的反应沉淀途径，d）所述获得的n个纳米颗粒分散体配方的平行，快速连续或半平行表征 ; 至少8种不同的纳米粒子分散体配方的阵列; 通过平行聚合方法制备m纳米二极体阵列的方法; 至少8种不同的纳米分散剂阵列; 通过并行固溶途径制备n个固溶体阵列的方法; 和至少8个不同的阵列。