公开(公告)号：JP2002119847A

公开(公告)日：2002-04-23

申请号：JP2001233053

申请日：2001-08-01

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  LYNN VAN ERDEN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: PROBLEM TO BE SOLVED: To provide an apparatus and a method for controlling and monitoring the progress and characteristics of more than one reaction for monitoring and controlling a process and displaying/analyzing data by using a computer. SOLUTION: The apparatus includes more than one vessel 102 for holding the reaction mixture and a system for controlling the rotation speed of a stirring blade 108 and the temperature of each reaction mixture or a group of the mixtures so as to be effective in the synthesis, screening and characterization of combined chemical library and further can include equipment for controlling independently pressures of respective vessels and a system for injecting a liquid to the vessel under the pressure other than the atmospheric pressure. Respective reaction mixtures are monitored, and monitored results are fed back to a process controller, then the data for deciding various characteristics including the reaction rate, product yield, viscosity and molecular weight of the reaction product can be obtained.

公开(公告)号：JP2002143671A

公开(公告)日：2002-05-21

申请号：JP2001233054

申请日：2001-08-01

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  LYNN VAN ERDEN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: PROBLEM TO BE SOLVED: To provide a device and a method which is for controlling and monitoring the progress of plural reactions and the characteristics, particularly effective for the synthesis, screening and characterization of a combination chemical library and has important advantages as compared to the conventional experimental reactor. SOLUTION: A parallel reactor system 100 contains generally plural vessels 102 for holding reaction mixtures and a system for controlling the stirring speed and the temperature of the respective reaction mixtures or a group of the reaction mixtures of a reactor block 106 and can contain an equipment for controlling the pressure in each vessel individually and a system for injecting a liquid into the vessel under the pressure except the atmospheric pressure. The monitoring of each reaction mixture brings the feed back to a process controller and simultaneously gives data for deciding various characteristics of the reaction product, which includes the reaction rate, the product yield, the viscosity and the molecular weight.

公开(公告)号：JP2002316042A

公开(公告)日：2002-10-29

申请号：JP2002019230

申请日：2002-01-28

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DALES G CAMERON ,  DIAMOND GARY M ,  FRANK TREVOR G ,  FREITAG CHRISTOPHER J ,  HIGASHIHARA KENNETH S ,  MURPHY VINCE ,  TROTH JONAH R ,  CHANDLER WILLIAM H JR ,  HUFFMAN DAVE

IPC: B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: PROBLEM TO BE SOLVED: To provide a parallel reactor system suitable for the handling of fluid substances containing slurry substance and to provide a method concerning the same. SOLUTION: The parallel reactor system is provided with a reactor 9, a vessel to be placed in the reactor and holding a reaction mixture and a cannula for introducing fluid reaction substances to the vessel. A robot system 23 enables the operation of inserting the cannula into a cannula path in the reactor 9 for conveying the reactant containing the slurry to a corresponding vessel and pulling off the cannula from the cannula path after the conveyance. The related method and the cannula design are also disclosed.

公开(公告)号：CA2419700C

公开(公告)日：2006-10-17

申请号：CA2419700

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： NIELSEN RALPH B ,  HAJDUK DAMIAN A ,  DALES G CAMERON ,  TURNER HOWARD ,  MATSIEV LEONID ,  WANG PEI ,  VAN BEEK JOHANNES A M ,  VAN ERDEN LYNN ,  MCFARLAND ERIC ,  MANSKY PAUL

IPC: B01J19/18 ,  B01J19/00 ,  G01N31/00 ,  G01N33/00 ,  G05B19/042 ,  G05D23/19

Abstract: Devices and methods for controlling and monitoring the progress and properti es of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but als o offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixture s or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injectin g liquids into the vessels at a pressure different than ambient pressure. In situ monitorin g of individual reaction mixtures provides feedback for process controllers, and also provid es data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods a re disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：AT279973T

公开(公告)日：2004-11-15

申请号：AT01116442

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  B01F7/16

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：CA2306807C

公开(公告)日：2003-11-25

申请号：CA2306807

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MCFARLAND ERIC ,  WANG PEI ,  MANSKY PAUL ,  VAN BEEK JOHANNES A M ,  DALES G CAMERON ,  MATSIEV LEONID ,  VAN ERDEN LYNN ,  TURNER HOWARD

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: Devices and methods for controlling and monitoring the progress and properti es of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injectin g liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for proces s controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：AU3742599A

公开(公告)日：1999-10-25

申请号：AU3742599

申请日：1999-04-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CARLSON ERIC ,  SAFIR ADAM ,  PETRO MIROSLAV ,  NIELSEN RALPH B ,  LEE THOMAS S ,  FRECHET JEAN M J ,  DALES G CAMERON ,  KUEBLER SIGRID C ,  BENNETT JAMES

IPC: G01N37/00 ,  B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  C40B40/18 ,  G01N1/00 ,  G01N15/02 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/08

Abstract: A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.

公开(公告)号：CA2527935A1

公开(公告)日：1999-10-14

申请号：CA2527935

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： LEE THOMAS S ,  FRECHET JEAN M J ,  DALES G CAMERON ,  KUEBLER SIGRID C ,  SAFIR ADAM ,  CARLSON ERIC ,  PETRO MIROSLAV ,  BENNETT JAMES ,  NIELSEN RALPH B

IPC: G01N30/54 ,  G01N30/24 ,  G01N30/30 ,  G01N30/36 ,  G01N30/74 ,  G01N35/10

Abstract: A method for characterizing a polymer sample that includes the steps of withdrawing a polymer sample from a sample container into an injection probe of an auto- sampler where the probe is heated to maintain the withdrawn sample at a temperature of not less than about 75 degrees Celsius while resident in the probe. The heated injection probe resides in a first environment maintained at about ambient temperature while withdrawing the polymer sample. The method further includes loading at least a portion of the withdrawn sample into an injection port or a loading port of a liquid chromatography system where the injection port or loading port is adaptable for fluid communication with a chromatographic column. The chromatographic column resides in a heated second environment maintained at a temperature of not less than about 75 degrees Celsius. The loaded sample is injected into a mobile phase of the liquid chromatography system. The sample is maintained at a temperature but not les s than about 75 degrees Celsius during a period of time including from when the sample is withdrawn from the sample container to when the sample is within the heated second environment. The injected sample is chromatographically separated and a property of the sample or a composition thereof is detected.

公开(公告)号：DE60211760D1

公开(公告)日：2006-07-06

申请号：DE60211760

申请日：2002-01-21

Applicant: SYMYX TECHNOLOGIES INC

Inventor： DALES G CAMERON ,  TROTH JONAH R ,  HIGASHIHARA KENNETH S ,  DIAMOND GARY ,  MURPHY VINCE ,  CHANDLER WILLIAM H JR ,  FRANK TREVOR G ,  FREITAG J CHRISTOPHER ,  HUFFMAN DAVE

IPC: B01J19/00 ,  B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: A method of preparing and delivering a slurry into a series of vessels in a reactor, said method comprising: (1) mixing a particulate solid material and a liquid dispersing medium and agitating the mixture to form a substantially homogeneous first slurry in which said particulate solid material is suspended in the liquid; (2) aspirating said first slurry into a cannula carried by a robot system while the slurry is substantially homogeneous; (3) operating the robot system to insert the cannula into the reactor;(4) delivering the slurry from the cannula into the vessel while the cannula is in said reactor; and (5) repeating (2)-(4) for a second vessel with said first slurry or repeating (2)-(4) for a second vessel with a second slurry.

公开(公告)号：CA2369222C

公开(公告)日：2006-06-20

申请号：CA2369222

申请日：2002-01-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： FREITAG J CHRISTOPHER ,  DALES G CAMERON ,  HIGASHIHARA KENNETH S ,  FRANK TREVOR G ,  TROTH JONAH R ,  DIAMOND GARY M ,  HUFFMAN DAVE ,  CHANDLER WILLIAM H JR ,  MURPHY VINCE

IPC: B01J19/00 ,  B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J8/14 ,  B01L3/00 ,  B01L7/00 ,  B08B3/00 ,  B25J9/02 ,  B25J11/00 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including slurries, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods and cannula designs are also disclosed.