公开(公告)号：CA2527935C

公开(公告)日：2008-02-12

申请号：CA2527935

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： NIELSEN RALPH B ,  BENNETT JAMES ,  KUEBLER SIGRID C ,  PETRO MIROSLAV ,  SAFIR ADAM ,  CARLSON ERIC ,  FRECHET JEAN M J ,  DALES G CAMERON ,  LEE THOMAS S

IPC: G01N35/10

Abstract: A method for characterizing a polymer sample that includes the steps of withdrawing a polymer sample from a sample container into an injection probe of an auto- sampler where the probe is heated to maintain the withdrawn sample at a temperature of not less than about 75 degrees Celsius while resident in the probe. The heated injection probe resides in a first environment maintained at about ambient temperature while withdrawing the polymer sample. The method further includes loading at least a portion of the withdrawn sample into an injection port or a loading port of a liquid chromatography system where the injection port or loading port is adaptable for fluid communication with a chromatographic column. The chromatographic column resides in a heated second environment maintained at a temperature of not less than about 75 degrees Celsius. The loaded sample is injected into a mobile phase of the liquid chromatography system. The sample is maintained at a temperature but not les s than about 75 degrees Celsius during a period of time including from when the sample is withdrawn from the sample container to when the sample is within the heated second environment. The injected sample is chromatographically separated and a property of the sample or a composition thereof is detected.

公开(公告)号：AU1978102A

公开(公告)日：2002-04-22

申请号：AU1978102

申请日：2001-10-10

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KUEBLER SIGRID C ,  BENNETT JAMES

IPC: B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  C40B60/14 ,  G01N1/00 ,  G01N15/02 ,  G01N21/25 ,  G01N21/51 ,  G01N21/53 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/62 ,  G01N30/88 ,  G01N33/44 ,  G01N35/08 ,  G01N21/49

公开(公告)号：AU9599898A

公开(公告)日：1999-04-27

申请号：AU9599898

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

公开(公告)号：AU2003277429A1

公开(公告)日：2004-05-04

申请号：AU2003277429

申请日：2003-10-17

Applicant: SYMYX TECHNOLOGIES INC

Inventor： SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG ,  MATSIEV LEONID ,  BENNETT JAMES ,  PINKAS DANIEL M

IPC: G01F23/296 ,  G01N9/00 ,  G01N11/16 ,  G01N29/036 ,  G01N29/34 ,  G01N29/02

公开(公告)号：AT239227T

公开(公告)日：2003-05-15

申请号：AT98949736

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

公开(公告)号：CA2317743A1

公开(公告)日：2000-06-22

申请号：CA2317743

申请日：1999-12-10

Applicant: SYMYX TECHNOLOGIES INC

Inventor： BENNETT JAMES ,  MANSKY PAUL

IPC: B01J19/00 ,  C40B30/08 ,  C40B40/18 ,  G01N9/00 ,  G01N11/00 ,  G01N25/00 ,  G01N25/18 ,  G01N25/20 ,  G01N27/72 ,  G01N37/00 ,  G01N31/00

Abstract: A modular materials characterization apparatus includes a sensor array (10) disposed on a substrate (16), with a standardized array and contact pad (14) format; electronic test and measurement apparatus (54) for sending electrical signals to and receiving electrical signals from the sensor array (10); an apparatus for making electrical contact (50) to the sensors in the standardized array format; an apparatus for routing signals (129) between one or more selected sensors and the electronic test and measurement apparatus and a computer (52) with a computer program recorded therein for controlling the operation of the apparatus. The sensor array (10) is preferably arranged in a standardized format used in combinatorial chemistry applications for rapid deposition of sample materials on the sensor array. An interconnection apparatus (40) and sensor array (10) and contact pad (32) allow measurement of many different material properties by using substrates carrying different sensor types.

公开(公告)号：AU3742599A

公开(公告)日：1999-10-25

申请号：AU3742599

申请日：1999-04-03

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CARLSON ERIC ,  SAFIR ADAM ,  PETRO MIROSLAV ,  NIELSEN RALPH B ,  LEE THOMAS S ,  FRECHET JEAN M J ,  DALES G CAMERON ,  KUEBLER SIGRID C ,  BENNETT JAMES

IPC: G01N37/00 ,  B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  C40B40/18 ,  G01N1/00 ,  G01N15/02 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/08

Abstract: A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.

公开(公告)号：CA2527935A1

公开(公告)日：1999-10-14

申请号：CA2527935

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： LEE THOMAS S ,  FRECHET JEAN M J ,  DALES G CAMERON ,  KUEBLER SIGRID C ,  SAFIR ADAM ,  CARLSON ERIC ,  PETRO MIROSLAV ,  BENNETT JAMES ,  NIELSEN RALPH B

IPC: G01N30/54 ,  G01N30/24 ,  G01N30/30 ,  G01N30/36 ,  G01N30/74 ,  G01N35/10

Abstract: A method for characterizing a polymer sample that includes the steps of withdrawing a polymer sample from a sample container into an injection probe of an auto- sampler where the probe is heated to maintain the withdrawn sample at a temperature of not less than about 75 degrees Celsius while resident in the probe. The heated injection probe resides in a first environment maintained at about ambient temperature while withdrawing the polymer sample. The method further includes loading at least a portion of the withdrawn sample into an injection port or a loading port of a liquid chromatography system where the injection port or loading port is adaptable for fluid communication with a chromatographic column. The chromatographic column resides in a heated second environment maintained at a temperature of not less than about 75 degrees Celsius. The loaded sample is injected into a mobile phase of the liquid chromatography system. The sample is maintained at a temperature but not les s than about 75 degrees Celsius during a period of time including from when the sample is withdrawn from the sample container to when the sample is within the heated second environment. The injected sample is chromatographically separated and a property of the sample or a composition thereof is detected.

公开(公告)号：DE69814035T2

公开(公告)日：2003-10-23

申请号：DE69814035

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

公开(公告)号：AU2368900A

公开(公告)日：2000-07-03

申请号：AU2368900

申请日：1999-12-17

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAJDUK DAMIAN ,  BENNETT JAMES ,  JAIN RAKESH

IPC: B01J19/00 ,  C40B40/18 ,  G01N23/20