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公开(公告)号：DE602005026577D1
公开(公告)日：2011-04-07
申请号：DE602005026577
申请日：2005-10-11
Applicant: UBE INDUSTRIES
Inventor： KONEGAWA TADAYOSHI , MIYATA HIROYUKI , YAMAMOTO YASUHITO
IPC: C12P41/00 , C07C227/18 , C07C229/34 , C12P13/22
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公开(公告)号：ES2249588T3
公开(公告)日：2006-04-01
申请号：ES02738658
申请日：2002-06-12
Applicant: UBE INDUSTRIES , CHUGAI PHARMACEUTICAL CO LTD
Inventor： MIYATA HIROYUKI , TAKAMA AKIRA , YAMAMOTO YASUHITO , ATAKA KIKUO
IPC: C07H17/08
Abstract: Un procedimiento para preparar un compuesto de eritromicina que comprende someter el compuesto 1 6, 9- hemicetal de 2¿-O-acetil-4¿¿- O-formil-11-oxo-8, 9- anhidroeritromicina A representado por la fórmula (1): en la que R1 y R2 cada uno de ellos representa un grupo alquilo inferior, a alquilación, en la que el compuesto 1 se hace reaccionar con un agente alquilante en presencia de una base en un disolvente mixto de 0, 18 a 1, 05 equivalentes de agua basándose en la cantidad de compuesto 1 y un disolvente orgánico, proporcionando el compuesto 6, 9- hemiacetal de 2¿-O- acetil-4¿¿-O-formil-11-oxo-12-alcoxi- 8, 9-anhidroeritromicina A (compuesto 3) representado por la fórmula (3): en la que R representa un grupo alquilo inferior, R1 y R2 tienen los mismos significados que se han definido anteriormente.
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公开(公告)号：DE60206921D1
公开(公告)日：2005-12-01
申请号：DE60206921
申请日：2002-06-12
Applicant: UBE INDUSTRIES , CHUGAI PHARMACEUTICAL CO LTD
Inventor： MIYATA HIROYUKI , TAKAMA AKIRA , YAMAMOTO YASUHITO , ATAKA KIKUO
IPC: C07H17/08
Abstract: Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. [Image] R 1, R 2lower alkyl.
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公开(公告)号：DE69716962D1
公开(公告)日：2002-12-12
申请号：DE69716962
申请日：1997-08-19
Applicant: UBE INDUSTRIES
Inventor： YAMAMOTO YASUHITO , YONEDA YASUHIRO , ATAKA KIKUO , YOKOTA NAOYUKI
IPC: C07C63/70 , C07C69/76 , C07C67/307 , C07C51/363
Abstract: The present invention is to provide a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid, esters thereof, which are useful as a starting material for synthesizing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.
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15.发明专利
公开(公告)号：AU2016265801B2
公开(公告)日：2020-10-08
申请号：AU2016265801
申请日：2016-05-19
Applicant: UBE INDUSTRIES LTD
Inventor： IWAMURA RYO , TSUZAKI YASUNORI , SETOGUCHI HIROYUKI , AKAZA HIROTO , YAMAMOTO YASUHITO , TAKAMA AKIRA , KUNO YUKA
IPC: C07D209/52 , A61K31/403 , A61P1/00 , A61P1/10 , A61P3/04 , A61P17/04 , A61P25/18 , A61P25/24 , A61P25/30 , A61P25/36 , A61P43/00
Abstract: The objective of the present invention is to provide: a crystal having high purity and excellent properties (such as stability and solubility) of a highly safe compound with few side effects, said compound having μ-opioid receptor antagonist activity; and a method for producing this crystal. A crystal of a salt or hydrate thereof, said salt being composed of a compound represented by formula (I) and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid and oxalic acid. (In the formula, R
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Patent Agency Ranking
公开(公告)号：AT499449T
公开(公告)日：2011-03-15
申请号：AT05793727
申请日：2005-10-11
Applicant: UBE INDUSTRIES
Inventor： KONEGAWA TADAYOSHI , MIYATA HIROYUKI , YAMAMOTO YASUHITO
IPC: C12P13/04 , C07C227/18 , C07C229/34 , C12P13/22 , C12P41/00
Abstract: The present invention relates to a process for preparing an optically active (S or R)-²-amino acid represented by the formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, aryl group or heteroaryl group each of which may have a substituent(s), and * represents an asymmetric carbon atom, and an optically active (R or S)-²-amino acid ester represented by the formula (III): wherein R has the same meaning as defined above, R 1 represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has a reverse absolute configuration to that of the compound of the formula (II), which comprises selectively hydrolyzingwater and one of enantiomers of a ²-amino acid ester represented by the formula (I): wherein R and R 1 have the same meanings as defined above, which is a racemic mixture, in the presence of a hydrolase in an organic solvent.
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公开(公告)号：DE60206921T2
公开(公告)日：2006-07-20
申请号：DE60206921
申请日：2002-06-12
Applicant: UBE INDUSTRIES , CHUGAI PHARMACEUTICAL CO LTD
Inventor： MIYATA HIROYUKI , TAKAMA AKIRA , YAMAMOTO YASUHITO , ATAKA KIKUO
IPC: C07H17/08
Abstract: Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. [Image] R 1, R 2lower alkyl.
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公开(公告)号：CA2583322A1
公开(公告)日：2006-04-13
申请号：CA2583322
申请日：2005-10-11
Applicant: UBE INDUSTRIES
Inventor： MIYATA HIROYUKI , KONEGAWA TADAYOSHI , YAMAMOTO YASUHITO
IPC: C12P41/00 , C07B53/00 , C07C227/18 , C07C229/34
Abstract: The present invention relates to a process for preparing an optically active (S or R)-²-amino acid represented by the formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, aryl group or heteroaryl group each of which may have a substituent(s), and * represents an asymmetric carbon atom, and an optically active (R or S)-²-amino acid ester represented by the formula (III): wherein R has the same meaning as defined above, R 1 represents an alkyl group which may have a substituent(s), and * represents an asymmetric carbon atom, provided that it has a reverse absolute configuration to that of the compound of the formula (II), which comprises selectively hydrolyzingwater and one of enantiomers of a ²-amino acid ester represented by the formula (I): wherein R and R 1 have the same meanings as defined above, which is a racemic mixture, in the presence of a hydrolase in an organic solvent.
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公开(公告)号：AU2003235253A1
公开(公告)日：2003-11-03
申请号：AU2003235253
申请日：2003-04-18
Applicant: UBE INDUSTRIES
Inventor： YAMAMOTO YASUHITO , MIYATA HIROYUKI , KONEGAWA TADAYOSHI , SAKATA KAZUMA
Abstract: The present invention is to provide a 3-substituted oxyglutaric acid diester compound represented by the following formula (I): wherein R may be the same or different from each other, and represents a substituted or unsubstituted alkyl group, R represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aralkyl group or a substituted or unsubstituted aryl group, and an optically active 3-substituted oxyglutaric acid monoester compound represented by the following formula (IV) : wherein R and R have the same meanings as defined above, and processes for preparing the same.
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公开(公告)号：DE69716962T2
公开(公告)日：2003-07-03
申请号：DE69716962
申请日：1997-08-19
Applicant: UBE INDUSTRIES
Inventor： YAMAMOTO YASUHITO , YONEDA YASUHIRO , ATAKA KIKUO , YOKOTA NAOYUKI
IPC: C07C63/70 , C07C69/76 , C07C67/307 , C07C51/363
Abstract: The present invention is to provide a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid, esters thereof, which are useful as a starting material for synthesizing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.
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