公开(公告)号：AT307820T

公开(公告)日：2005-11-15

申请号：AT02738658

申请日：2002-06-12

Applicant: UBE INDUSTRIES ,  CHUGAI PHARMACEUTICAL CO LTD

Inventor： MIYATA HIROYUKI ,  TAKAMA AKIRA ,  YAMAMOTO YASUHITO ,  ATAKA KIKUO

IPC: C07H17/08

Abstract: Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. [Image] R 1, R 2lower alkyl.

公开(公告)号：DE60205912D1

公开(公告)日：2005-10-06

申请号：DE60205912

申请日：2002-06-12

Applicant: UBE INDUSTRIES ,  CHUGAI PHARMACEUTICAL CO LTD

Inventor： MIYATA HIROYUKI ,  TAKAMA AKIRA ,  KAWAGUCHI TATSUYA ,  SAKATA KAZUMA ,  ATAKA KIKUO ,  OKU MASAYOSHI ,  SUENAGA HIROYUKI

IPC: C07H17/08

Abstract: Preparation of a 2'-O-acetyl-4''-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound (IV) comprises formylating a 2'-O-acetyl-8,9-anhydroerythromycin A compound (II) to give a 2'-O-acetyl-4''-O-formyl-erythromycin A compound (III); reacting (III) with an acid to give the corresponding hemiketal compound; and adding aqueous base to precipitate (IV) in free form as crystals. Preparation of a 2'-O-acetyl-4''-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (IV) comprises: (i) formylating a 2'-O-acetyl-8,9-anhydroerythromycin A compound of formula (II) to give a 2'-O-acetyl-4''-O-formyl-erythromycin A compound of formula (III); (ii) reacting (III) with an acid to give the corresponding hemiketal compound; and (iii) adding aqueous base to precipitate (IV) in free form as crystals. [Image] [Image] R1, R2lower alkyl.

公开(公告)号：DE60206921T2

公开(公告)日：2006-07-20

申请号：DE60206921

申请日：2002-06-12

Applicant: UBE INDUSTRIES ,  CHUGAI PHARMACEUTICAL CO LTD

Inventor： MIYATA HIROYUKI ,  TAKAMA AKIRA ,  YAMAMOTO YASUHITO ,  ATAKA KIKUO

IPC: C07H17/08

Abstract: Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. Preparation of a 2'-O-acetyl-4''-O-formyl-11-oxo-12-alkoxy-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (III) comprises reacting a 2'-O-acetyl-4''-O-formyl-11-oxo-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (I) with an alkylating agent in a mixed solvent comprising 0.18-1.05 equivalents water to (I) and an organic solvent. [Image] R 1, R 2lower alkyl.

公开(公告)号：AT303395T

公开(公告)日：2005-09-15

申请号：AT02736057

申请日：2002-06-12

Applicant: UBE INDUSTRIES ,  CHUGAI PHARMACEUTICAL CO LTD

Inventor： MIYATA HIROYUKI ,  TAKAMA AKIRA ,  KAWAGUCHI TATSUYA ,  SAKATA KAZUMA ,  ATAKA KIKUO ,  OKU MASAYOSHI ,  SUENAGA HIROYUKI

IPC: C07H17/08

Abstract: Preparation of a 2'-O-acetyl-4''-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound (IV) comprises formylating a 2'-O-acetyl-8,9-anhydroerythromycin A compound (II) to give a 2'-O-acetyl-4''-O-formyl-erythromycin A compound (III); reacting (III) with an acid to give the corresponding hemiketal compound; and adding aqueous base to precipitate (IV) in free form as crystals. Preparation of a 2'-O-acetyl-4''-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound of formula (IV) comprises: (i) formylating a 2'-O-acetyl-8,9-anhydroerythromycin A compound of formula (II) to give a 2'-O-acetyl-4''-O-formyl-erythromycin A compound of formula (III); (ii) reacting (III) with an acid to give the corresponding hemiketal compound; and (iii) adding aqueous base to precipitate (IV) in free form as crystals. [Image] [Image] R1, R2lower alkyl.

公开(公告)号：DE69716962T2

公开(公告)日：2003-07-03

申请号：DE69716962

申请日：1997-08-19

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  YONEDA YASUHIRO ,  ATAKA KIKUO ,  YOKOTA NAOYUKI

IPC: C07C63/70 ,  C07C69/76 ,  C07C67/307 ,  C07C51/363

Abstract: The present invention is to provide a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid, esters thereof, which are useful as a starting material for synthesizing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.

公开(公告)号：CA2554539A1

公开(公告)日：2005-08-11

申请号：CA2554539

申请日：2004-11-22

Applicant: UBE INDUSTRIES

Inventor： MIYATA HIROYUKI ,  ATAKA KIKUO ,  MAE KAZUHIRO ,  YOSHIDA JUNICHI ,  KAWAGUCHI TATSUYA

IPC: C07C45/00 ,  C07C45/29 ,  C07C45/51 ,  C07C45/78 ,  C07C47/02 ,  C07C47/54 ,  C07C49/04 ,  C07C49/403

Abstract: A process for producing from a primary or secondary alcohol the correspondin g aldehyde or ketone compound at relatively high temperature with a short peri od of time with high yield, which process comprises the step (1) of reacting a sulfoxide compound with its activator to thereby obtain an activated compoun d, the step (2) of reacting this activated compound with a primary or secondary alcohol to thereby obtain an alkoxysulfonium salt and the step (3) of reacti ng this reaction product with a base to thereby obtain an aldehyde or ketone, wherein at least one of these steps, preferably the steps (1) and (2) are carried out with the use of a microreactor.

公开(公告)号：DE60102120D1

公开(公告)日：2004-04-01

申请号：DE60102120

申请日：2001-11-15

Applicant: UBE INDUSTRIES

Inventor： MIYATA HIROYUKI ,  HONMA TAKASHI ,  YAMAMOTO YASUHITO ,  ATAKA KIKUO

IPC: C07B61/00 ,  C07D498/04

Abstract: The present invention provides a novel 7a-alkoxy-4H-pyrano-Ä3,2-dÜ-oxazol-2(3H)-one represented by the formula (I): wherein R and R each represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group; R represents an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group or an aralkyl group, provided that a 2-alkenyl group is excluded from the alkenyl group of R ; and R represents an alkyl group, an aryl group, an alkoxycarbonyl group or a cyano group, and a process for producing the same which comprises reacting 5-alkoxy-2(3H)-oxazolone with an alpha , beta -unsaturated ketone in the presence of a Lewis acid in a solvent.

公开(公告)号：DE69526443T2

公开(公告)日：2002-12-12

申请号：DE69526443

申请日：1995-10-04

Applicant: UBE INDUSTRIES

Inventor： ATAKA KIKUO ,  MIYATA HIROYUKI ,  KONO MASAHIKO ,  YOKOTA NAOYUYKI ,  YAMAMOTO YASUHITO

IPC: C07F7/18 ,  C07D495/04

Abstract: The present invention relates to a 2-silyloxy-4,5,6,7-tetrahydrothienoÄ3,2-cÜpyridine represented by the formula (I): wherein R , R and R each independently represent an alkyl group having 1 to 10 carbon atoms or an aryl group, and a salt thereof and a process for preparing the same, and a 5-alkyl-2-silyloxy-4,5,6,7-tetrahydrothienoÄ3,2-cÜ-pyridine represented by the formula (IV): wherein R , R and R represent the same meanings as described above; R represents a hydrogen atom, an alkoxycarbonyl group having 2 to 10 carbon atoms, an acyl group having 2 to 10 carbon atoms or a cycloalkylcarbonyl group having 4 to 10 carbon atoms; and R represents a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, which is useful as a synthetic intermediate of an antiplatelet medicine and an elastase inhibitor, etc., and a process for preparing the same.

公开(公告)号：FR2473508A1

公开(公告)日：1981-07-17

申请号：FR8100163

申请日：1981-01-07

Applicant: UBE INDUSTRIES

Inventor： UMEMURA SUMIO ,  IWATA FUMIO ,  ATAKA KIKUO ,  SHIRAISHI HIROSHI

IPC: B01J23/00 ,  C07B61/00 ,  C07C51/00 ,  C07C51/347 ,  C07C51/367 ,  C07C59/64 ,  C07C67/00

Abstract: 3-Alkoxy-4-hydroxyphenylacetic acid useful as intermediate for preparation of pharmaceuticals is prepared by catalytic reduction with hydrogen using a palladium catalyst of corresponding 3-alkoxy-4-hydroxymandelic acid occurring as the reaction product between 2-alkoxyphenol and glyoxylic acid at high conversion and yield.

公开(公告)号：CA2554539C

公开(公告)日：2012-10-23

申请号：CA2554539

申请日：2004-11-22

Applicant: UBE INDUSTRIES

Inventor： ATAKA KIKUO ,  MIYATA HIROYUKI ,  KAWAGUCHI TATSUYA ,  YOSHIDA JUNICHI ,  MAE KAZUHIRO

IPC: C07C45/00 ,  C07C45/29 ,  C07C45/51 ,  C07C45/78 ,  C07C47/02 ,  C07C47/54 ,  C07C49/04 ,  C07C49/403

Abstract: The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield including a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.