公开(公告)号：DE69716962T2

公开(公告)日：2003-07-03

申请号：DE69716962

申请日：1997-08-19

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  YONEDA YASUHIRO ,  ATAKA KIKUO ,  YOKOTA NAOYUKI

IPC: C07C63/70 ,  C07C69/76 ,  C07C67/307 ,  C07C51/363

Abstract: The present invention is to provide a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid, esters thereof, which are useful as a starting material for synthesizing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.

公开(公告)号：DE69716962D1

公开(公告)日：2002-12-12

申请号：DE69716962

申请日：1997-08-19

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  YONEDA YASUHIRO ,  ATAKA KIKUO ,  YOKOTA NAOYUKI

IPC: C07C63/70 ,  C07C69/76 ,  C07C67/307 ,  C07C51/363

Abstract: The present invention is to provide a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid, esters thereof, which are useful as a starting material for synthesizing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.

公开(公告)号：EP0968994A4

公开(公告)日：2000-01-05

申请号：EP97935807

申请日：1997-08-19

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  YONEDA YASUHIRO ,  ATAKA KIKUO ,  YOKOTA NAOYUKI

IPC: C07C63/70 ,  C07C69/76 ,  C07C51/363 ,  C07C67/307

CPC classification number: C07C69/76 ,  C07C63/70

Abstract: Substituted trifluorobenzoic acids and esters thereof, useful as a starting material for the synthesis of quinolonecarboxylic acid compounds useful as medicines, antibacterial agents and antiviral agents, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid and esters thereof; and processes for producing these compounds and further 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.

公开(公告)号：EP2829542A4

公开(公告)日：2015-08-26

申请号：EP13765244

申请日：2013-03-15

Applicant: UBE INDUSTRIES

Inventor： TOKITO SHIZUO ,  KUMAKI DAISUKE ,  SHIMA HIDETAKA ,  ODA HIROYUKI ,  TANAKA YASUHIRO ,  KAKITA KAZUAKI ,  MACHIDA TOSHIKAZU ,  YONEDA YASUHIRO ,  OMATA YOUJI ,  SHIMANO TETSURO

IPC: C07D513/04 ,  C09D11/00 ,  H01L29/786 ,  H01L51/05 ,  H01L51/30 ,  H01L51/50

CPC classification number: C07D513/04 ,  C08G61/123 ,  C08G61/126 ,  C08G2261/1642 ,  C08G2261/1644 ,  C08G2261/3223 ,  C08G2261/3246 ,  C08G2261/364 ,  C08G2261/414 ,  C08G2261/51 ,  C08G2261/91 ,  C08G2261/92 ,  C08G2261/95 ,  C09B57/00 ,  C09D11/52 ,  H01L27/3274 ,  H01L51/0071 ,  H01L51/0097 ,  H01L51/0545 ,  H01L51/42 ,  H01L51/5012 ,  H01L51/5056 ,  H01L51/5072 ,  H01L2251/5338 ,  Y02E10/549

Abstract: The present invention relates to a benzobis(thiadiazole) derivative represented by the formula (1): wherein R represents a group containing at least one fluorine atom (with the proviso that fluorine atom (F) and trifluoromethyl group (-CF 3 ) are excluded), and m represents an integer of from 1 to 10.

公开(公告)号：EP3048107A4

公开(公告)日：2017-05-31

申请号：EP14845080

申请日：2014-08-29

Applicant: UBE INDUSTRIES

Inventor： TOKITO SHIZUO ,  KUMAKI DAISUKE ,  MAMADA MASASHI ,  FUKUDA KENJIRO ,  TANAKA YASUHIRO ,  SHIMA HIDETAKA ,  YONEDA YASUHIRO ,  FUJITA HARUNORI ,  KAKITA KAZUAKI ,  OMATA YOUJI ,  YAMADA NATSUKO ,  HONMA TAKASHI ,  MACHIDA TOSHIKAZU

IPC: H01L51/30 ,  C07D513/02 ,  C07D513/04 ,  C09D11/52 ,  H01L27/32 ,  H01L29/786 ,  H01L51/46 ,  H01L51/54

CPC classification number: H01L51/0071 ,  C07D513/02 ,  C07D513/04 ,  C09D11/52 ,  H01L27/3274 ,  H01L51/0068 ,  H01L51/0097 ,  H01L51/0558 ,  H01L51/0566 ,  H01L51/4253 ,  H01L51/5056 ,  H01L51/5072 ,  Y02E10/549

Abstract: The present invention relates to a benzobis(thiadiazole) derivative represented by the following general formula (1): wherein R 1 represents a linear or branched alkyl group, or any one of the groups of the following formula (2): wherein R represents a linear or branched alkyl group; R 2 represents a hydrogen atom; and R 3 represents a hydrogen atom, a linear or branched alkyl group, or any one of the groups of the formula (2); with the proviso that at least one of R 1 and R 3 represents any one of the groups of the formula (2); and two R 1 groups, two R 2 groups, and two R 3 groups may be the same as, or different from each other.

Abstract translation: 本发明涉及下述通式（1）所示的苯并双（噻二唑）衍生物，式中，R 1表示直链状或支链状的烷基或下述式（2）的基团中的任一种：式中，R表示 直链或支链烷基; R 2代表氢原子; 并且R 3表示氢原子，直链或支链烷基或式（2）的任何一个基团; 条件是R 1和R 3中的至少一个表示式（2）的任何一个基团; 并且两个R 1基团，两个R 2基团和两个R 3基团可以彼此相同或不同。

公开(公告)号：JPH08283217A

公开(公告)日：1996-10-29

申请号：JP8903695

申请日：1995-04-14

Applicant: UBE INDUSTRIES

Inventor： ATAKA KIKUO ,  YONEDA YASUHIRO ,  KONO MASAHIKO

IPC: B01J23/46 ,  B01J27/045 ,  C07B61/00 ,  C07C213/02 ,  C07C217/76 ,  C07C221/00 ,  C07C223/06

Abstract: PURPOSE: To obtain 3-fluoro-4-chloro-6-aminobenzaldehyde (acetal) as a new compound capable of giving quinolines having antiallergic activity in high yield, thus useful as an intermediate for antiallergic agents. CONSTITUTION: This new compound is 3-fluoro-4-chloro-6-aminobenzaldehyde of formula I or a compound of formula II (R and R are each a 1-4C alkyl and may be bound to each other) (e.g. 3-fluoro-4-chloro-6-aminobenzaldehyde ethyleneacetal). The compound of formula I or formula II is obtained by catalyst hydrogen reduction of a compound of formula III [X is F; X is Cl; Y is formyl or an acetal group of the formula CH(OR )(OR )] in the presence of a platinum- or ruthenium-contg. catalyst in an organic solvent under pressure.

公开(公告)号：JPH08268974A

公开(公告)日：1996-10-15

申请号：JP6959095

申请日：1995-03-28

Applicant: UBE INDUSTRIES

Inventor： ATAKA KIKUO ,  YONEDA YASUHIRO ,  KONO MASAHIKO

IPC: C07C201/14 ,  C07C205/34 ,  C07C205/44

Abstract: PURPOSE: To obtain 3-fluoro-4-chloro-6-nitrobenzaldehyde and its acetal which can give a quinoline in high yield and is useful as a synthetic intermediate for an antiallergic. CONSTITUTION: 3-Fluoro-4-chloro-6-nitrobenzaldehyde of formula I. The compound of formula I is obtained by nitrating 3-fluoro-4-chloro-benzaldehyde with the mixed acid. 3-Fluoro-4-chloro-6-nitrobenzaldehyde acetal of formula II is prepared by reaction of 3,4-dichlor-6-nitrobenzaldehyde acetal with an alkali metal fluoride in a polar solvent or by reaction of the compound of formula I with an aliphatic alcohol or an ortho-acid trialkyl ester in the presence of an acid catalyst.

公开(公告)号：JP2011153094A

公开(公告)日：2011-08-11

申请号：JP2010015155

申请日：2010-01-27

Applicant: Ube Industries Ltd ,  宇部興産株式会社

Inventor： NISHINO SHIGEYOSHI ,  YONEDA YASUHIRO ,  ODA HIROYUKI

IPC: C07C319/24 ,  C07C321/28 ,  C07C323/09

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a diaryl disulfide compound in high yield without requiring complicated operation by using an easily available reaction reagent.
SOLUTION: The method for producing the diaryl disulfide compound represented by the formula: Ar-S-S-Ar (wherein, Ar is aryl or heteroaryl which may have a substituent) includes reacting an arylsulfonyl compound represented by the formula: Ar-SO
2 -L (wherein, Ar has the same meanings as the above; and L is a leaving group), a reducing agent of a bromide represented by the formula: M-Br (wherein, M is a metal ion, a quaternary ammonium ion or a phosphonium ion) or a bromonium ion, and sulfuric acid in the presence of an organic acid.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供一种以高产率制备二芳基二硫化物化合物的方法，而不需要使用容易获得的反应试剂的复杂操作。 解决方案：由式Ar-SS-Ar（其中Ar是可以具有取代基的芳基或杂芳基）表示的二芳基二硫化物的制备方法包括使下式表示的芳基磺酰基化合物：Ar-SO （其中，Ar具有与上述相同的含义; L为离去基团），由式M-Br表示的溴化还原剂（其中，M为 金属离子，季铵离子或鏻离子）或溴鎓离子，和硫酸在有机酸存在下进行。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JPH1067706A

公开(公告)日：1998-03-10

申请号：JP22284696

申请日：1996-08-23

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  YONEDA YASUHIRO ,  ATAKA KIKUO

IPC: C07C51/363 ,  C07B61/00 ,  C07C63/70 ,  C07C67/08 ,  C07C69/78

Abstract: PROBLEM TO BE SOLVED: To produce a 2,4,5-trifluoro-3-iodobenzoic acid and its ester which are useful as a material for 2,4,5-trifluoro-3-trifluoromethyl benzoic acids used as a starting material for production of antimicrobial and antiviral agents, easily and at a high yield. SOLUTION: This 2,4,5-trifluoro-3-iodobenzoic acid of formula I (R is an alkyl, cycloalkyl or aralkyl) is produced by making a 2,4,5-trifluoroiodobenzoic acid of formula II with a N-iodosuccinimide of formula III in the presence of trifluoromethane sulfonic acid. Furthermore, a 2,4,5-trifluoro-3-iodobenzoic ester of formula IV is obtained by reaction of a reactant mixture that contains a compound of formula I with an alcohol of the formula of R-OH.

公开(公告)号：JPH1059896A

公开(公告)日：1998-03-03

申请号：JP21704696

申请日：1996-08-19

Applicant: UBE INDUSTRIES

Inventor： YOKOTA NAOYUKI ,  YONEDA YASUHIRO ,  ATAKA KIKUO

IPC: B01J27/122 ,  C07B61/00 ,  C07C51/363 ,  C07C63/70

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing 2,4,5-trifluoro-3-iodobenzoic acid useful as a raw material for the production of 2,4,5-trifluoro-3- trifluoromethylbenzoic acid which is an important intermediate for synthesizing quinolone carboxylic acid compounds useful as medicines, antibacterial agents and antiviral agents. SOLUTION: A method for producing 2,3,4-trifluoro-3-iodobenzoic acid comprises reacting 3-amino-2,4,5-trifluorobenzoic acid with hydroiodic acid in the presence of sodium nitrite and a cuprous halide in a solvent.