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公开(公告)号：AU2016374375A1
公开(公告)日：2018-06-28
申请号：AU2016374375
申请日：2016-12-14
Applicant: UCB BIOPHARMA SPRL
Inventor： ADAMS RALPH , BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , MARSHALL DIANE
IPC: C07K16/24 , A61K39/395 , C07K14/525
Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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公开(公告)号：SG11201708151TA
公开(公告)日：2017-11-29
申请号：SG11201708151T
申请日：2016-04-22
Applicant: UCB BIOPHARMA SPRL
Inventor： HEYWOOD SAM PHILIP , WILD GAVIN BARRY , HANIF RAZWAN , LE PAGE CHRISTOPHER JOHN
Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.
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公开(公告)号：AU2016259720A1
公开(公告)日：2017-11-09
申请号：AU2016259720
申请日：2016-05-09
Applicant: UCB BIOPHARMA SPRL
Inventor： BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , SMITH BRYAN JOHN
Abstract: The disclosure relates to antibody fusion proteins specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.
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公开(公告)号：UY37035A
公开(公告)日：2017-07-31
申请号：UY37035
申请日：2016-12-16
Applicant: UCB BIOPHARMA SPRL
Inventor： MARSHALL DIANE , ADAMS RALPH , BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , SHAW STEVAN GRAHAM , LIGHTWOOD DANIEL JOHN
Abstract: La invención se refiere a moléculas de anticuerpo multiespecífico con especificidad por TNF-alfa, IL-17A e IL-17F, a usos terapéuticos de las moléculas de anticuerpo y a métodos para producir dichas moléculas de anticuerpo.
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公开(公告)号：SI2334705T1
公开(公告)日：2017-05-31
申请号：SI200931626
申请日：2009-09-25
Applicant: UCB BIOPHARMA SPRL
Inventor： ADAMS RALPH , HANCOCK LAURA , HEYWOOD SAM PHILIP
IPC: C07K16/00
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Patent Agency Ranking
公开(公告)号：AU2015279128A1
公开(公告)日：2016-12-01
申请号：AU2015279128
申请日：2015-06-25
Applicant: UCB BIOPHARMA SPRL
Inventor： BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
IPC: C07K16/46
Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH
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公开(公告)号：CA2983057A1
公开(公告)日：2016-10-27
申请号：CA2983057
申请日：2016-04-20
Applicant: UCB BIOPHARMA SPRL
Inventor： HEYWOOD SAM PHILIP , WILD GAVIN BARRY
Abstract: The present invention provides a method for recovering a human VH3domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human VH3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.
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公开(公告)号：SI1644412T1
公开(公告)日：2015-12-31
申请号：SI200432279
申请日：2004-07-01
Applicant: UCB BIOPHARMA SPRL
Inventor： HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP
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公开(公告)号：HRP20151252T1
公开(公告)日：2015-12-18
申请号：HRP20151252
申请日：2015-11-23
Applicant: UCB BIOPHARMA SPRL
Inventor： HUMPHREYS DAVID PAUL , HEYWOOD SAM PHILIP
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公开(公告)号：DK1644412T3
公开(公告)日：2015-12-14
申请号：DK04743158
申请日：2004-07-01
Applicant: UCB BIOPHARMA SPRL
Inventor： HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
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