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公开(公告)号：EP3286205A1
公开(公告)日：2018-02-28
申请号：EP16717915
申请日：2016-04-20
Applicant: UCB BIOPHARMA SPRL
Inventor： HEYWOOD SAM PHILIP , WILD GAVIN BARRY
CPC classification number: C07K1/22 , C07K16/065 , C07K16/18 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/62 , C07K2317/622 , C07K2317/624
Abstract: The present invention provides a method for recovering a human VH3domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human VH3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.
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公开(公告)号：EP3286204A1
公开(公告)日：2018-02-28
申请号：EP16719824
申请日：2016-04-22
Applicant: UCB BIOPHARMA SPRL
Inventor： HEYWOOD SAM PHILIP , WILD GAVIN BARRY , HANIF RAZWAN , LE PAGE CHRISTOPHER JOHN
CPC classification number: C07K1/1136 , A61K39/39591 , C07K1/1133 , C07K16/18 , C07K16/2878 , C07K2317/31
Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.
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3.发明公开
公开(公告)号：EP3286220A1
公开(公告)日：2018-02-28
申请号：EP16721103
申请日：2016-04-22
Applicant: UCB BIOPHARMA SPRL
Inventor： HEYWOOD SAM PHILIP , WILD GAVIN BARRY , LE PAGE CHRISTOPHER JOHN , HANIF RAZWAN
CPC classification number: C07K16/2878 , C07K16/18 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/55 , C07K2317/624 , C07K2317/66
Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a)a thermal conversion stepof holding the composition comprising the antibody molecule at a temperature in the range 30 to 60°C for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.
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公开(公告)号：EP3294767A1
公开(公告)日：2018-03-21
申请号：EP16720869
申请日：2016-05-09
Applicant: UCB BIOPHARMA SPRL
Inventor： BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , SMITH BRYAN JOHN
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/18 , C07K16/283 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The disclosure relates to antibody fusion proteins specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.
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公开(公告)号：MX392543B
公开(公告)日：2025-03-19
申请号：MX2017013333
申请日：2017-10-16
Applicant: UCB BIOPHARMA SPRL
Inventor： WILD GAVIN BARRY , HEYWOOD SAM PHILIP
Abstract: La presente invención se refiere a un método para recuperar un anticuerpo que contiene un dominio VH3 humano en forma monomérica. En particular, la presente invención proporciona un nuevo método que permite la recuperación de anticuerpos monoméricos que contienen el dominio VH3 humano a partir de una mezcla que contiene formas monoméricas y multiméricas del anticuerpo.
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Patent Agency Ranking
公开(公告)号：PL3161007T3
公开(公告)日：2020-02-28
申请号：PL15732228
申请日：2015-06-25
Applicant: UCB BIOPHARMA SPRL
Inventor： BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
IPC: C07K16/46
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公开(公告)号：DK1644412T4
公开(公告)日：2018-11-12
申请号：DK04743158
申请日：2004-07-01
Applicant: UCB BIOPHARMA SPRL
Inventor： HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL
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公开(公告)号：CL2018001661A1
公开(公告)日：2018-10-19
申请号：CL2018001661
申请日：2018-06-18
Applicant: UCB BIOPHARMA SPRL
Inventor： ADAMS RALPH , BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , MARSHALL DIANE , LIGHTWOOD DANIEL JOHN
IPC: A61K39/395 , C07K14/525 , C07K16/24
Abstract: LA INVENCIÓN SE REFIERE A MOLÉCULAS DE ANTICUERPO QUE TIENEN ESPECIFICIDAD PARA TNF ALFA, USOS TERAPÉUTICOS DE LAS MOLÉCULAS DE ANTICUERPO Y MÉTODOS PARA PRODUCIR DICHAS MOLÉCULAS DE ANTICUERPO.
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9.发明专利
公开(公告)号：CL2018001660A1
公开(公告)日：2018-10-19
申请号：CL2018001660
申请日：2018-06-18
Applicant: UCB BIOPHARMA SPRL
Inventor： SHAW STEVAN GRAHAM , ADAMS RALPH , BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , MARSHALL DIANE , LIGHTWOOD DANIEL JOHN
Abstract: LA INVENCIÓN ESTÁ RELACIONADA CON LAS MOLÉCULAS DE ANTICUERPOS MULTIESPECÍFICAS QUE TIENEN ESPECIFICIDAD PARA TNF-ALFA, IL-17A E IL-17F, USOS TERAPÉUTICOS DE LAS MOLÉCULAS DE ANTICUERPOS Y MÉTODOS PARA PRODUCIR TALES MOLÉCULAS DE ANTICUERPOS.
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公开(公告)号：AU2016369307A1
公开(公告)日：2018-07-12
申请号：AU2016369307
申请日：2016-12-14
Applicant: UCB BIOPHARMA SPRL
Inventor： ADAMS RALPH , BHATTA PALLAVI , DAVE EMMA , HEYWOOD SAM PHILIP , HUMPHREYS DAVID PAUL , MARSHALL DIANE , SHAW STEVAN GRAHAM , LIGHTWOOD DANIEL JOHN
Abstract: The invention relates to multi-specific antibody molecules having specificity for TNF alpha, IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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