公开(公告)号：MX2014002769A

公开(公告)日：2014-06-11

申请号：MX2014002769

申请日：2012-09-10

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  LIGTHWOOD DANIEL JOHN ,  TYSON KERRY LOUISE ,  KNIGHT DAVID EDWARD ORMONDE ,  HERVÉ KARINE JEANNINE MADELEINE ,  COMPSON JOANNE ELIZABETH ,  PAGE MATTHEW JON TIMOTHY ,  PAYNE ANDREW CHARLES ,  FISHER NICOLA LOUISE ,  MACKENZIE BRENDON ,  COX MATTHEW

IPC: C07K16/12 ,  A61K39/40 ,  A61P31/04

Abstract: La presente invención describe la derivación y selección de anticuerpos capaces de neutralizar las exotoxinas principales; TcdA y TcdB de Clostridium dificcile. La invención también describe nuevas propiedades de neutralización y unión a antígeno de Mab individuales y mezclas de estos.

公开(公告)号：SG11201400193SA

公开(公告)日：2014-05-29

申请号：SG11201400193S

申请日：2012-09-10

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  LIGHTWOOD DANIEL JOHN ,  TYSON KERRY LOUISE ,  KNIGHT DAVID EDWARD ORMONDE ,  HERVÉ KARINE JEANNINE MADELEINE ,  COMPSON JOANNE ELIZABETH ,  PAGE MATTHEW JON TIMOTHY ,  PAYNE ANDREW CHARLES ,  FISHER NICOLA LOUISE ,  MACKENZIE BRENDON ,  COX MATTHEW

IPC: C07K16/12 ,  A61K39/40 ,  A61P31/04

Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.

公开(公告)号：SG10201701055WA

公开(公告)日：2017-03-30

申请号：SG10201701055W

申请日：2012-09-10

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  LIGHTWOOD DANIEL JOHN ,  TYSON KERRY LOUISE ,  KNIGHT DAVID EDWARD ORMONDE ,  HERVÉ KARINE JEANNINE MADELEINE ,  COMPSON JOANNE ELIZABETH ,  PAGE MATTHEW JON TIMOTHY ,  PAYNE ANDREW CHARLES ,  FISHER NICOLA LOUISE ,  MACKENZIE BRENDON ,  COX MATTHEW

Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.

公开(公告)号：NZ623293A

公开(公告)日：2016-05-27

申请号：NZ62329312

申请日：2012-09-10

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  LIGHTWOOD DANIEL JOHN ,  TYSON KERRY LOUISE ,  KNIGHT DAVID EDWARD ORMONDE ,  HERVÉ KARINE JEANNINE MADELEINE ,  COMPSON JOANNE ELIZABETH ,  PAGE MATTHEW JON TIMOTHY ,  PAYNE ANDREW CHARLES ,  FISHER NICOLA LOUISE ,  MACKENZIE BRENDON ,  COX MATTHEW

IPC: C07K16/12 ,  A61K39/40 ,  A61P31/04

Abstract: Disclosed is a pharmaceutical composition comprising a monoclonal antibody suitable for reducing the duration and/or severity of diarrhoea or morbidity and/or mortality in a patient with Clostridium difficile infection or at risk of said infection wherein the antibody is specific to: antigen Clostridium difficile toxin A (TcdA) and binds 3 or more times in the range S1827-D2249 or G2205-R2608 of SEQ ID NO: 171 with an EC50 in the range 0.1 to 10 ng/ml when toxin is used at an LD80 or higher.

公开(公告)号：TN2014000101A1

公开(公告)日：2015-07-01

申请号：TN2014000101

申请日：2014-03-07

Applicant: UCB PHARMA SA

Inventor： HUMPHREYS DAVID PAUL ,  LIGHTWOOD DANIEL JOHN ,  TYSON KERRY LOUISE ,  KNIGHT DAVID EDWARD ORMONDE ,  HERVE KARINE JEANNINE MADELEINE ,  COMPSON JOANNE ELIZABETH ,  PAGE MATTHEW JON TIMOTHY ,  PAYNE ANDREW CHARLES ,  FISHER NICOLA LOUISE ,  MACKENZIE BRENDON ,  COX MATTHEW

IPC: A61K39/40 ,  A61P31/04 ,  C07K16/12

Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.