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1.发明专利
公开(公告)号：PE15472014A1
公开(公告)日：2014-10-25
申请号：PE0003532014
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVE KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
CPC classification number: C07K16/1282 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/56911 , G01N33/573 , G01N33/6854 , G01N2333/91097
Abstract: SE REFIERE A UN ANTICUERPO MONOCLONAL ESPECIFICO FRENTE AL ANTIGENO TCDA O TCDB, QUE COMPRENDE UNA CADENA PESADA EN EL DOMINIO VARIABLE QUE TIENE UNA CDR QUE COMPRENDE LA SECUENCIA DADA EN SEQ ID NO: 44 PARA CDR-H1, UNA CDR EN SEQ ID NO: 45 PARA CDR-H2 Y UNA CDR EN SEQ ID NO: 46 PARA CDR-H3; Y UNA CADENA LIGERA EN EL DOMINIO VARIABLE QUE TIENE UNA CDR QUE COMPRENDE LA SECUENCIA DADA EN SEQ ID NO: 41 PARA CDR-L1, UNA CDR EN SEQ ID NO: 42 PARA CDR-L2 Y UNA CDR EN SEQ ID NO:43 PARA CDR-L3. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO O LA PROFILAXIS DE LA INFECCION POR CLOSTRIDIUM DIFFICILE.
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2.发明专利
公开(公告)号：CO6930310A2
公开(公告)日：2014-04-28
申请号：CO14082286
申请日：2014-04-15
Applicant: UCB PHARMA SA
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3.发明专利
公开(公告)号：ECSP14013316A
公开(公告)日：2014-08-29
申请号：ECSP14013316
申请日：2014-04-16
Applicant: UCB PHARMA SA
Inventor： COX MATTHEW , TYSON KERRY LOUISE , HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , KNIGHT DAVID EDWARD ORMONDE , HERVÉ KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON
Abstract: La presente invención describe la derivación y selección de anticuerpos capaces de neutralizar las principales exotoxinas; TcdA y TcdB de Clostridium difficile. La invención también describe nuevas propiedades de neutralización y de unión de antígeno de Mabs individuales y mezclas de los mismos.
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公开(公告)号：EA032475B1
公开(公告)日：2019-06-28
申请号：EA201400345
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVE KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: Визобретенииописаныфармацевтическаякомпозициядлясниженияпродолжительностии/илитяжестидиареи, заболеваемостии/илисмертностипациента, инфицированного Clostridium difficile илиимеющегорискуказанногозаражения, включающаяодноилиболеемоноклональныхантител, специфичныхв отношенииантигена TcdA123, атакжеееприменениедляполучениялекарственногосредствадлялеченияилипрофилактикиинфекции Clostridium difficile илисвязанныхс нейосложнений.
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公开(公告)号：ZA201402760B
公开(公告)日：2016-03-30
申请号：ZA201402760
申请日：2014-04-15
Applicant: UCB PHARMA SA
Inventor： COX MATTHEW , MACKENZIE BRENDON , FISHER NICOLA LOUISE , PAYNE ANDREW CHARLES , PAGE MATTHEW JON TIMOTHY , COMPSON JOANNE ELIZABETH , HERVE KARINE JEANNINE MADELEINE , KNIGHT DAVID EDWARD ORMONDE , TYSON KERRY LOUISE , LIGHTWOOD DANIEL JOHN , HUMPHREYS DAVID PAUL
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.
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Patent Agency Ranking
公开(公告)号：AU2012307157A1
公开(公告)日：2014-04-24
申请号：AU2012307157
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVE KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of
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公开(公告)号：CA2848611A1
公开(公告)日：2013-03-21
申请号：CA2848611
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVE KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
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公开(公告)号：SG10201701055WA
公开(公告)日：2017-03-30
申请号：SG10201701055W
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVÉ KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotox-in; TcdA of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of in-dividual Mabs and mixtures thereof.
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公开(公告)号：NZ623293A
公开(公告)日：2016-05-27
申请号：NZ62329312
申请日：2012-09-10
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVÉ KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: Disclosed is a pharmaceutical composition comprising a monoclonal antibody suitable for reducing the duration and/or severity of diarrhoea or morbidity and/or mortality in a patient with Clostridium difficile infection or at risk of said infection wherein the antibody is specific to: antigen Clostridium difficile toxin A (TcdA) and binds 3 or more times in the range S1827-D2249 or G2205-R2608 of SEQ ID NO: 171 with an EC50 in the range 0.1 to 10 ng/ml when toxin is used at an LD80 or higher.
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公开(公告)号：TN2014000101A1
公开(公告)日：2015-07-01
申请号：TN2014000101
申请日：2014-03-07
Applicant: UCB PHARMA SA
Inventor： HUMPHREYS DAVID PAUL , LIGHTWOOD DANIEL JOHN , TYSON KERRY LOUISE , KNIGHT DAVID EDWARD ORMONDE , HERVE KARINE JEANNINE MADELEINE , COMPSON JOANNE ELIZABETH , PAGE MATTHEW JON TIMOTHY , PAYNE ANDREW CHARLES , FISHER NICOLA LOUISE , MACKENZIE BRENDON , COX MATTHEW
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
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