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公开(公告)号：AU2006242476B2
公开(公告)日：2012-05-31
申请号：AU2006242476
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , WINTERS AARON GEORGE , WINKLER DAVID , ROBINSON MARTYN KIM , LU HSIENG SEN , LAWSON ALASTAIR , PASZTY CHRISTOPHER , LATHAM JOHN
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：BRPI0610197A2
公开(公告)日：2010-06-01
申请号：BRPI0610197
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , JAMES ALISTAIR , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：HUE057097T2
公开(公告)日：2022-04-28
申请号：HUE19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：LT3670528T
公开(公告)日：2021-12-27
申请号：LT19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：EA037044B1
公开(公告)日：2021-01-29
申请号：EA201400933
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: C07K16/18 , A61K39/395 , A61P19/08 , A61P19/10 , C07K14/51
Abstract: Настоящееизобретениеотноситсяк антителу, котороесвязываетсяс фрагментомсклеростина, кеговариантами различнымспособамегоприменения.
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Patent Agency Ranking
公开(公告)号：NZ591636A
公开(公告)日：2012-10-26
申请号：NZ59163606
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMAN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Provided are specified amino acid sequences for sclerostin binding agents, and corresponding specific antigens. The antibodies are useful for treating bone-related disorders in mammals. The antibody or antigen-binding fragment thereof can increase bone formation, bone mineral density, bone mineral content, bone mass, bone quality or bone strength in a mammal, and/or can block the inhibitory effect of sclerostin in a cell based mineralization assay.
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公开(公告)号：AU2012216589A1
公开(公告)日：2012-09-20
申请号：AU2012216589
申请日：2012-08-31
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： HOFFMANN KELLY SUE , HENRY ALISTAIR JAMES , WINTERS AARON GEORGE , WINKLER DAVID , ROBINSON MARTYN KIM , LU HSIENG SEN , LAWSON ALASTAIR , PASZTY CHRISTOPHER , LATHAM JOHN
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided. WO 2006/119062 PCTIUS2006/016345 00) Loop 3 LoopU2
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公开(公告)号：NO20076046A
公开(公告)日：2008-01-30
申请号：NO20076046
申请日：2007-11-23
Applicant: UCB PHARMA SA
Inventor： LATHAM JOHN , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
IPC: C07K14/51 , C07K14/435 , C07K16/18 , C07K16/28
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
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公开(公告)号：ES2902548T3
公开(公告)日：2022-03-28
申请号：ES19211623
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMAN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Un anticuerpo monoclonal que se une a esclerostina humana; aumenta al menos uno de formación de hueso, densidad mineral ósea, contenido mineral óseo, masa ósea, calidad ósea y fuerza ósea en un mamífero; y se une a una parte de la esclerostina humana que consiste en los aminoácidos 51-64, 73-90, 101-117 y 138-149 de la SEQ ID NO: 1, en donde dicha parte tiene las tres de: (a) un enlace disulfuro entre los aminoácidos 57 y 111; (b) un enlace disulfuro entre los aminoácidos 82 y 142; y (c) un enlace disulfuro entre los aminoácidos 86 y 144.
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公开(公告)号：SI3670528T1
公开(公告)日：2022-01-31
申请号：SI200632414
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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