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公开(公告)号：LT2556071T
公开(公告)日：2017-01-25
申请号：LT11764988
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04 , C07D403/10 , C07D403/14
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公开(公告)号：AU2011238384A1
公开(公告)日：2012-09-27
申请号：AU2011238384
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D403/04 , A61K31/5377 , A61P35/00 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：CA2791324A1
公开(公告)日：2011-10-13
申请号：CA2791324
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：CA2792641C
公开(公告)日：2018-05-01
申请号：CA2792641
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W , CUMMING GRAHAM
IPC: C07D403/04 , C07D231/56 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
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公开(公告)号：CA2756568C
公开(公告)日：2018-02-13
申请号：CA2756568
申请日：2010-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LI SZE WAN , LIU YONG , PAULS HEINZ W , EDWARDS LOUISE G , FORREST BRYAN T , FEHER MIKLOS , PATEL NARENDRA KUMAR B , PAN GUOHUA
IPC: C07D403/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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Patent Agency Ranking
公开(公告)号：PL2556071T3
公开(公告)日：2017-02-28
申请号：PL11764988
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04 , C07D403/10 , C07D403/14
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公开(公告)号：NZ602350A
公开(公告)日：2014-05-30
申请号：NZ60235011
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
Abstract: Disclosed herein are spiro-cyclopropyl-indolinone compounds, and the use thereof as kinase inhibitors in the treatment of a cancer, such as lung cancer, breast cancer, colon cancer, brain cancer, neuroblastoma, prostate cancer, melanoma, glioblastoma multiform, ovarian cancer, lymphoma, leukemia, melanoma, sarcoma, paraneoplasia, osteosarcoma, germinoma, glioma and mesothelioma. In one embodiment the compound is (1R,2S)-(E)-5’-fluoro-2-{ 3-(4-(morpholinomethyl)styryl-1H-indazol-6-yl)spiro[cyclopropane-1,3’-indolin]-2’-one 2,2,2-trifluoroacetate.
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公开(公告)号：CA2792641A1
公开(公告)日：2011-10-13
申请号：CA2792641
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W , CUMMING GRAHAM
IPC: C07D403/04 , C07D231/56 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
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公开(公告)号：CA2756568A1
公开(公告)日：2010-10-14
申请号：CA2756568
申请日：2010-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LI SZE-WAN , LIU YONG , PAULS HEINZ W , EDWARDS LOUISE G , FORREST BRYAN T , FEHER MIKLOS , PATEL NARENDRA KUMAR B , PAN GUOHUA
IPC: C07D403/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：CY1118610T1
公开(公告)日：2017-07-12
申请号：CY161101184
申请日：2016-11-17
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04 , C07D403/10 , C07D403/14
Abstract: Ηεφεύρεσηαφοράένωσηπουαντιπροσωπεύεταιαπόταφαρμακευτικώςαποδεκτάάλατααυτήςμετονακόλουθοσυντακτικότύπο: (I). Ενώσειςπουαντιπροσωπεύονταιαπότονενλόγωσυντακτικότύποείναιαναστολείςκινάσεωνκαισυνεπώςκοινοποιούνταιεδώγιατηθεραπευτικήαγωγήτουκαρκίνου. Ορισμοίγιατιςμεταβλητέςστοσυντακτικότύποπαρέχονταιστοπαρόν.
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