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公开(公告)号：WO2011123946A8
公开(公告)日：2011-12-08
申请号：PCT/CA2011000386
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK , SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
Abstract translation: 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：（I）。 由该结构式表示的化合物是激酶抑制剂，因此在此公开用于治疗癌症。 本文提供了结构式中变量的定义。
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2.发明申请SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES 审中-公开合成2-（1H-吲哚-6-YL） - 吡啶并[环丙基-1,3'-吲哚] -2'-ONES
公开(公告)号：WO2011123947A8
公开(公告)日：2011-12-22
申请号：PCT/CA2011000387
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK , CUMMING GRAHAM , PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W
Inventor： CUMMING GRAHAM , PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W
IPC: C07D403/04 , C07D231/56 , C07D413/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
Abstract translation: 本发明涉及用于制备由结构式（A）表示的螺环丙基吲哚啉酮化合物的新型合成方法：（A）或其药学上可接受的盐。 还包括本文所述的合成中间体。
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3.发明公开SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES 有权合成操作员2-（1H-吲哚-6-YL） - 吡咯并[环丙烷-1,3'-吲哚] -2'-ONE
公开(公告)号：EP2556070A4
公开(公告)日：2013-10-23
申请号：EP11764989
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： CUMMING GRAHAM , PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D231/56 , C07D403/04 , C07D403/10 , C07D403/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：EP2417127A4
公开(公告)日：2012-08-29
申请号：EP10761154
申请日：2010-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LL SZE-WAN , LIU YONG , PAULS HEINZ W , EDWARDS LOUISE G , FORREST BRYAN T , FEHER MIKLOS , PATEL NARENDRA KUMAR B , PAN GUOHUA
IPC: C07D403/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/14
CPC classification number: A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
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5.发明公开
公开(公告)号：EP2766352A4
公开(公告)日：2015-06-03
申请号：EP12840107
申请日：2012-10-12
Applicant: UNIV HEALTH NETWORK UHN
Inventor： PAULS HEINZ W , LAUFER RADOSLAW , LIU YONG , LI SZE-WAN , FORREST BRYAN T , LANG YUNHUI , PATEL NARENDRA KUMAR B , EDWARDS LOUISE G , NG GRACE , SAMPSON PETER BRENT , FEHER MIKLOS , AWREY DONALD E
IPC: C07D409/12 , A61K31/416 , A61P35/00 , C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/107 , C07D493/10
CPC classification number: C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/107 , C07D493/10
Abstract: The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
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Patent Agency Ranking
公开(公告)号：EP2556071A4
公开(公告)日：2013-09-04
申请号：EP11764988
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04 , C07D403/10 , C07D403/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：SMT201600430B
公开(公告)日：2017-01-10
申请号：SM201600430
申请日：2016-11-24
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
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公开(公告)号：EA023173B1
公开(公告)日：2016-04-29
申请号：EA201270752
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
Abstract: Изобретениеотноситсяк соединению, представленномуследующейструктурнойформулой, иегофармацевтическиприемлемымсолям:Указанныесоединенияявляютсяингибиторами polo-подобныхкиназ 4 (PLK4) и Aurora кинази могутбытьиспользованыдлялечениязлокачественнойопухоли.
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公开(公告)号：AU2011238384B2
公开(公告)日：2015-02-19
申请号：AU2011238384
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D403/04 , A61K31/5377 , A61P35/00 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：HUE030651T2
公开(公告)日：2017-05-29
申请号：HUE11764988
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: A61P35/00
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