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1.发明申请
公开(公告)号：WO2009015485A1
公开(公告)日：2009-02-05
申请号：PCT/CA2008001415
申请日：2008-08-01
Applicant: UNIV HEALTH NETWORK , PAULS HEINZ W , FORREST BRYAN T , SAMPSON PETER BRENT , LIU YONG , LAUFER RADOSLAW , LANG YUNHUI , FEHER MIKIOS , YAO YI , PAN GUOHUA
Inventor： PAULS HEINZ W , FORREST BRYAN T , SAMPSON PETER BRENT , LIU YONG , LAUFER RADOSLAW , LANG YUNHUI , FEHER MIKIOS , YAO YI , PAN GUOHUA
IPC: C07D211/58 , A61K31/17 , A61K31/397 , A61K31/40 , A61K31/445 , A61P3/10 , A61P35/00 , C07C275/32 , C07D205/04 , C07D207/50 , C07D211/56
CPC classification number: C07D211/58 , C07C275/36 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12
Abstract: A CPTl inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
Abstract translation: CPT1抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
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2.发明申请SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES 审中-公开合成2-（1H-吲哚-6-YL） - 吡啶并[环丙基-1,3'-吲哚] -2'-ONES
公开(公告)号：WO2011123947A8
公开(公告)日：2011-12-22
申请号：PCT/CA2011000387
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK , CUMMING GRAHAM , PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W
Inventor： CUMMING GRAHAM , PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W
IPC: C07D403/04 , C07D231/56 , C07D413/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.
Abstract translation: 本发明涉及用于制备由结构式（A）表示的螺环丙基吲哚啉酮化合物的新型合成方法：（A）或其药学上可接受的盐。 还包括本文所述的合成中间体。
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公开(公告)号：WO2008109991A8
公开(公告)日：2008-12-18
申请号：PCT/CA2008000440
申请日：2008-03-06
Applicant: UNIV HEALTH NETWORK , PAULS HEINZ W , SAMPSON PETER BRENT , FORREST BRYAN T , LAUFER RADOSLAW , LIU YONG , FEHER MIKLOS , YAO YI , PAN GUOHUA
Inventor： PAULS HEINZ W , SAMPSON PETER BRENT , FORREST BRYAN T , LAUFER RADOSLAW , LIU YONG , FEHER MIKLOS , YAO YI , PAN GUOHUA
IPC: C07C275/28 , A61K31/195 , A61K31/34 , A61K31/381 , A61K31/41 , A61K31/44 , A61K31/495 , A61P35/00 , C07C233/52 , C07C233/83 , C07C237/42 , C07C275/06 , C07C307/06 , C07C307/10 , C07C311/19 , C07C311/29 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D277/44 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04
CPC classification number: C07D409/06 , C07C1/26 , C07C17/10 , C07C2529/40 , C07D207/325 , C07D213/71 , C07D213/82 , C07D231/12 , C07D231/14 , C07D263/34 , C07D277/48 , C07D295/215 , C07D307/24 , C07D307/68 , C07D307/82 , C07D333/34 , C07D333/40 , C07D401/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07C9/00 , C07C19/075
Abstract: A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject having cancer comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
Abstract translation: CPT抑制剂化合物由结构式（I）或其药学上可接受的盐表示：或其药学上可接受的盐。 药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。 治疗患有癌症的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。
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公开(公告)号：WO2011123946A8
公开(公告)日：2011-12-08
申请号：PCT/CA2011000386
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK , SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
Abstract translation: 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：（I）。 由该结构式表示的化合物是激酶抑制剂，因此在此公开用于治疗癌症。 本文提供了结构式中变量的定义。
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5.发明公开SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES 有权合成操作员2-（1H-吲哚-6-YL） - 吡咯并[环丙烷-1,3'-吲哚] -2'-ONE
公开(公告)号：EP2556070A4
公开(公告)日：2013-10-23
申请号：EP11764989
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： CUMMING GRAHAM , PATEL NARENDA KUMAR B , FORREST BRYAN T , LIU YONG , LI SZE-WAN , SAMPSON PETER BRENT , EDWARDS LOUISE G , PAULS HEINZ W
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D231/56 , C07D403/04 , C07D403/10 , C07D403/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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Patent Agency Ranking6.发明公开
公开(公告)号：EP2766352A4
公开(公告)日：2015-06-03
申请号：EP12840107
申请日：2012-10-12
Applicant: UNIV HEALTH NETWORK UHN
Inventor： PAULS HEINZ W , LAUFER RADOSLAW , LIU YONG , LI SZE-WAN , FORREST BRYAN T , LANG YUNHUI , PATEL NARENDRA KUMAR B , EDWARDS LOUISE G , NG GRACE , SAMPSON PETER BRENT , FEHER MIKLOS , AWREY DONALD E
IPC: C07D409/12 , A61K31/416 , A61P35/00 , C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/107 , C07D493/10
CPC classification number: C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/107 , C07D493/10
Abstract: The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
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公开(公告)号：EP2556071A4
公开(公告)日：2013-09-04
申请号：EP11764988
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04 , C07D403/10 , C07D403/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：EP2417127A4
公开(公告)日：2012-08-29
申请号：EP10761154
申请日：2010-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LL SZE-WAN , LIU YONG , PAULS HEINZ W , EDWARDS LOUISE G , FORREST BRYAN T , FEHER MIKLOS , PATEL NARENDRA KUMAR B , PAN GUOHUA
IPC: C07D403/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/14
CPC classification number: A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
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9.发明公开INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLMONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER 审中-公开吲唑基，苯并咪唑基，苯并三唑 - 取代INDOLMONDERIVATE作为激酶抑制剂用于癌症治疗
公开(公告)号：EP2235004A4
公开(公告)日：2011-05-04
申请号：EP08865534
申请日：2008-12-19
Applicant: UNIV HEALTH NETWORK
Inventor： PAULS HEINZ W , FORREST BRYAN T , LAUFER RADOSLAW , FEHER MIKLOS , SAMPSON PETER BRENT , PAN GUOHUA , LIU YONG , LI SZE-WAN
IPC: C07D403/06 , A61K31/416 , A61K31/4192 , A61P35/00 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC classification number: C07D403/06 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
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公开(公告)号：HUE030651T2
公开(公告)日：2017-05-29
申请号：HUE11764988
申请日：2011-04-06
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , LIU YONG , LI SZE-WAN , FORREST BRYAN T , PAULS HEINZ W , EDWARDS LOUISE G , FEHER MIKLOS , PATEL NARENDRA KUMAR B , LAUFER RADOSLAW , PAN GUOHUA
IPC: A61P35/00
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