公开(公告)号：CA2867444C

公开(公告)日：2021-04-13

申请号：CA2867444

申请日：2013-03-14

Applicant: UNIV HEALTH NETWORK

Inventor： TUSCHE MICHAEL W ,  MAK TAK W ,  OHASHI PAMELA S ,  LANG PHILIPP ,  LANG KARL ,  BRENNER DIRK ,  LIN GLORIA

IPC: A61K38/17 ,  A61P3/10 ,  A61P19/02 ,  A61P37/00

Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.

公开(公告)号：CA3050551A1

公开(公告)日：2018-07-26

申请号：CA3050551

申请日：2017-12-19

Applicant: UNIV HEALTH NETWORK

Inventor： ST-PAUL MICHAEL ,  OHASHI PAMELA S

IPC: C12N5/0783 ,  A61K35/17 ,  A61P35/00 ,  C07K14/54 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28

Abstract: There is described herein a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population of CD8+ T cells; and c) culturing or contacting the population of CD8+ T cells with IL-6.

公开(公告)号：CA2867444A1

公开(公告)日：2013-09-19

申请号：CA2867444

申请日：2013-03-14

Applicant: UNIV HEALTH NETWORK

Inventor： TUSCHE MICHAEL W ,  MAK TAK W ,  OHASHI PAMELA S ,  LANG PHILIPP ,  LANG KARL ,  BRENNER DIRK ,  LIN GLORIA

IPC: A61K38/17 ,  A61P3/10 ,  A61P19/02 ,  A61P37/00

Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.