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1.发明申请
公开(公告)号：WO2015132670A3
公开(公告)日：2015-12-23
申请号：PCT/IB2015000912
申请日：2015-03-07
Applicant: UNIV HEALTH NETWORK
Inventor： HERSHENFIELD BRIAN , MAK TAK W
IPC: C40B30/06 , C12N15/113 , C12Q1/00 , C12Q1/68 , C40B30/04 , C40B40/06 , G01N33/48 , G01N33/483
CPC classification number: C12Q1/6883 , A61K38/177 , A61K39/39541 , A61K39/39558 , A61K49/0008 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K16/2818 , C07K2317/76 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5088 , G01N2333/82 , A61K2300/00
Abstract: The present invention is directed to methods for identifying one or more target genes that modulate the activation state of dendritic cells. The methods are based on transfection of a siRNA library into immature bone marrow-derived dendritic cells and detecting the activation state of said cells. The identified one or more target genes can be further validated as candidate targets for induction of self-tolerance and treatment of autoimmune diseases.
Abstract translation: 本发明涉及用于鉴定调节树突状细胞的活化状态的一种或多种靶基因的方法。 所述方法基于将siRNA文库转染到未成熟骨髓来源的树突状细胞中并检测所述细胞的活化状态。 所鉴定的一个或多个靶基因可以进一步验证为诱导自身免疫性疾病的自我耐受和治疗的候选靶标。
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2.发明申请METHODS AND COMPOSITIONS FOR DETECTION OF TARGETS INVOLVED IN CANCER METASTASIS 审中-公开用于检测癌症参与的靶标的方法和组合物
公开(公告)号：WO2015132672A3
公开(公告)日：2015-12-17
申请号：PCT/IB2015000996
申请日：2015-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： BLASER HEIKO , MAK TAK W
CPC classification number: C12Q1/6883 , A61K38/177 , A61K39/39541 , A61K39/39558 , A61K49/0008 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K16/2818 , C07K2317/76 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5088 , G01N2333/82 , A61K2300/00
Abstract: The present application is directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis. The method comprises transfecting an immortalized cell line with one or more target cDNAs, said transfected cells further expressing a detectable reporter gene. The immortalized cell line lacks metastatic potential in absence of the transfected target cDNAs. Upon injection of said transfected cells into an animal, tumor cells are imaged, isolated and analyzed with respect to the presence of said target cDNAs thus identifying a gene(s) that modulates tumor metastasis.
Abstract translation: 本申请涉及用于鉴定参与癌症转移的靶核酸的方法和组合物。 该方法包括用一种或多种靶cDNA转染永生化细胞系，所述转染细胞进一步表达可检测的报道基因。 在不存在转染的靶cDNA的情况下，永生化细胞系缺乏转移潜力。 在将所述转染的细胞注射到动物中后，相对于所述靶cDNA的存在，对肿瘤细胞进行成像，分离和分析，从而鉴定调节肿瘤转移的基因。
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公开(公告)号：WO2013136193A3
公开(公告)日：2014-01-16
申请号：PCT/IB2013001179
申请日：2013-03-14
Applicant: UNIV HEALTH NETWORK , TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
Abstract translation: 本发明进一步涉及用于调节Toso蛋白活性的方法和组合物。 本发明还包括使用包括可溶性Toso蛋白的组合物治疗与炎症，自身免疫疾病和癌症相关的病症。
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公开(公告)号：WO2015132675A2
公开(公告)日：2015-09-11
申请号：PCT/IB2015001033
申请日：2015-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK W
IPC: A61K39/395
CPC classification number: C12Q1/6883 , A61K38/177 , A61K39/39541 , A61K39/39558 , A61K49/0008 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K16/2818 , C07K2317/76 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5088 , G01N2333/82 , A61K2300/00
Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and activity of such proteins.
Abstract translation: 本发明涉及用于调节参与免疫应答的蛋白质的方法和组合物。 本发明还提供了通过调节这些蛋白质的表达和活性来治疗自身免疫疾病和癌症的方法和组合物。
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公开(公告)号：WO2013136193A8
公开(公告)日：2014-05-08
申请号：PCT/IB2013001179
申请日：2013-03-14
Applicant: UNIV HEALTH NETWORK , TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
Abstract translation: 本发明还涉及用于调节Toso蛋白质活性的方法和组合物。 本发明还包括使用包含可溶性Toso蛋白的组合物治疗与炎症，自身免疫病和癌症相关的病症。
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Patent Agency Ranking
公开(公告)号：EP3113798A4
公开(公告)日：2017-12-06
申请号：EP15757961
申请日：2015-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK W
IPC: A61K39/395 , A61K38/17 , A61P35/00 , A61P37/00 , C07K14/705
CPC classification number: C12Q1/6883 , A61K38/177 , A61K39/39541 , A61K39/39558 , A61K49/0008 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K16/2818 , C07K2317/76 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5088 , G01N2333/82 , A61K2300/00
Abstract: The present invention is further directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis.
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公开(公告)号：EP3016982A4
公开(公告)日：2017-02-22
申请号：EP14820663
申请日：2014-07-02
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK W , LAI XIUQIU , TUSCHE MICHAEL W
CPC classification number: C07K16/2803 , C07K2317/622
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公开(公告)号：AU2019204594A1
公开(公告)日：2019-07-18
申请号：AU2019204594
申请日：2019-06-28
Applicant: UNIV HEALTH NETWORK
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Abstract: METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：AU2015225867B2
公开(公告)日：2020-02-06
申请号：AU2015225867
申请日：2015-03-06
Applicant: UNIV HEALTH NETWORK
Inventor： MAK TAK W
IPC: A61K39/395 , A61K38/17 , A61P35/00 , A61P37/00
Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response, specifically by modulating the expression and/or activity of the Toso protein. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and/or activity of the Toso protein.
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公开(公告)号：AU2017272172A1
公开(公告)日：2017-12-21
申请号：AU2017272172
申请日：2017-12-05
Applicant: UNIV HEALTH NETWORK
Inventor： TUSCHE MICHAEL W , MAK TAK W , OHASHI PAMELA S , LANG PHILIPP , LANG KARL , BRENNER DIRK , LIN GLORIA
Abstract: METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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