公开(公告)号：WO2011149972A3

公开(公告)日：2012-01-19

申请号：PCT/US2011037785

申请日：2011-05-24

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YOO HONGKI ,  SHISHKOV MILEN ,  GARDECKI JOSEPH ,  SHUBOCHKIN ROMAN ,  MORSE THEODORE ,  JAFFER AMIN FAROUC

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YOO HONGKI ,  SHISHKOV MILEN ,  GARDECKI JOSEPH ,  SHUBOCHKIN ROMAN ,  MORSE THEODORE ,  JAFFER AMIN FAROUC

IPC: A61B5/00 ,  G01B9/02 ,  G01N21/64

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract translation: 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光学芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：US09915819B2

公开(公告)日：2018-03-13

申请号：US15169917

申请日：2016-06-01

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： Xingde Li ,  Yicong Wu ,  Wenxuan Liang

IPC: G02B23/26 ,  G02B23/24 ,  G01N21/64 ,  G01N33/483 ,  G02B21/00 ,  G02B26/10 ,  A61B5/00 ,  G01N21/63 ,  G02B3/00 ,  A61B1/00

CPC classification number: G02B23/26 ,  A61B1/0017 ,  A61B5/0068 ,  A61B5/0084 ,  G01N21/636 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/0866 ,  G01N2201/10 ,  G02B3/0087 ,  G02B21/0008 ,  G02B23/243 ,  G02B23/2469 ,  G02B26/103

Abstract: The present invention is directed to a fiber optic device that enables multiphoton imaging with improved signal-to-noise ratio having a single piece of double-clad fiber (DCF). The device also includes all components for focusing, scanning and signal collection within an endomicroscope probe of 2.1 mm outer diameter (OD). The unprecedented imaging capability of this miniature endomicroscope is demonstrated herein via both ex vivo and in vivo experiments.

公开(公告)号：US20170135584A1

公开(公告)日：2017-05-18

申请号：US15359279

申请日：2016-11-22

Applicant: The General Hospital Corporation ,  Boston University

Inventor： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC: A61B5/00 ,  G01B9/02 ,  G01N21/65 ,  G01N21/64

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

公开(公告)号：US20120101374A1

公开(公告)日：2012-04-26

申请号：US13114845

申请日：2011-05-24

Applicant: Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

Inventor： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC: A61B6/00

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract translation: 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置成经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：US5307146A

公开(公告)日：1994-04-26

申请号：US962394

申请日：1992-10-16

Applicant: Marc D. Porter ,  Thomas P. Jones ,  Shelley J. Coldiron

Inventor： Marc D. Porter ,  Thomas P. Jones ,  Shelley J. Coldiron

IPC: G01N21/27 ,  G01J1/16 ,  G01N21/31 ,  G01N21/77 ,  G01N21/80 ,  G01J3/427

CPC classification number: G01N21/7703 ,  G01J2001/1636 ,  G01N2021/3181 ,  G01N2021/772 ,  G01N21/80 ,  G01N2201/062 ,  G01N2201/084 ,  G01N2201/0866

Abstract: A dual wavelength optical sensor for measuring chemical properties of a particular quantity, the optical sensor including a sensor probe having a thin sensing film whose optical characteristics are responsive to the chemical properties of the measured quantityThe United States Government has certain rights in this invention pursuant to Contract No. ITA87-02 between the U.S. Department of Commerce and Iowa State University.

Abstract translation: 一种用于测量特定量的化学性质的双波长光学传感器，所述光学传感器包括具有薄的感测膜的传感器探针，所述传感器探针的光学特性响应于所述测量量在至少两个不同波长的光的化学特性 当对至少两个不同波长的响应进行组合时，提供了测量的化学性质的自校准测量。 光源产生至少两个不同波长的光，并且单个光纤将来自光源的光传送到传感器探针。 样品检测器在传感器探头经过薄膜感测膜并从薄膜传感器接收来自传感器探针的光，并产生至少两个不同波长的光的光强度读数。 光学传感器还包括用于组合来自样本检测器的光强度读数的信号处理系统，以产生自校准的测量，其考虑到薄传感膜的光学特性的变化，否则这将有助于传感器响应中的不稳定性。

公开(公告)号：EP1099107B1

公开(公告)日：2009-01-07

申请号：EP99934902.0

申请日：1999-07-20

Applicant: PACKARD INSTRUMENT COMPANY

Inventor： RUSHBROOKE, John Gordon ,  HOOPER, Claire, Elizabeth

IPC: G01N21/64 ,  G01N21/76

CPC classification number: G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/0866

Abstract: Apparatus for detecting light emitted by assay samples is provided, in which light emitted by the sample is collected for transmission to a charge coupled device camera (74) by an optical fibre bundle. The cross-sectional area of the optical fibre bundle corresponds to the area of the sample, the end of which is located close to the sample for detecting any light emitted therefrom, and selected fibres (30) of those making up the bundle are separated from the remainder and extend to a source of excitation radiation (76) and serve to convey excitation radiation (if required) directly to a corresponding plurality of points distributed over the area of the end face of the bundle and therefore over the area of the sample. The remaining fibres (32, 38) of the bundle serve to collect emitted light (whether generated by fluorescence caused by excitation or otherwise) and provide a light path to the charge coupled device camera, wherein the ends of the excitation fibres and the ends of the emitted light collecting fibres are distributed uniformly over the area of the fibre bundle presented to the reaction site.

公开(公告)号：EP0604582A4

公开(公告)日：1994-04-28

申请号：EP92920962

申请日：1992-09-17

Applicant: UNIV IOWA STATE RES FOUND INC

Inventor： PORTER MARC D ,  JONES THOMAS P

IPC: G01N21/27 ,  G01J1/16 ,  G01N21/31 ,  G01N21/77 ,  G01N21/80 ,  G01N21/59 ,  G01N21/64 ,  G01N21/78

CPC classification number: G01N21/7703 ,  G01J2001/1636 ,  G01N21/80 ,  G01N2021/3181 ,  G01N2021/772 ,  G01N2201/062 ,  G01N2201/084 ,  G01N2201/0866

Abstract: A dual wavelength optical sensor for measuring the optical characteristics of sensing films which are responsive to a particular quantity to be measured. The optical sensor includes a light source (16, 18) for producing light outputs at two distinct wavelengths and transmitting twin components of light to first and second outputs. A time-shared optical fiber (26) receives the two distinct wavelengths of light from the first output and carries the light on a time-shared basis to a sensor probe (14). A sample detector (30) receives the two distinct wavelengths of light transmitted from the thin sensing film. A reference detector (34) receives the two distinct wavelengths of light from the second output and monitors the output intensity of the light source. A signal processing system (35) combines the measurements of the optical characteristics of the thin sensing film in response to each of the two distinct wavelengths to provide measurements which account for changes in the optical properties of the thin sensing film.

Abstract translation: 一种双波长光学传感器，用于测量响应于待测量的特定量的传感膜的光学特性。 该光学传感器包括用于产生两个不同波长的光输出并将双分量光传输到第一和第二输出端的光源（16,18）。 时间共享光纤（26）接收来自第一输出的两个不同波长的光，并将光以时间共享的方式传送到传感器探头（14）。 样本检测器（30）接收从薄传感膜传输的两个不同波长的光。 参考检测器（34）接收来自第二输出的两个不同波长的光并监测光源的输出强度。 信号处理系统（35）响应于两个不同波长中的每一个将薄传感膜的光学特性的测量值组合起来，以提供解释薄传感膜的光学性质变化的测量值。

公开(公告)号：JP4303889B2

公开(公告)日：2009-07-29

申请号：JP2000561485

申请日：1999-07-20

Applicant: パッカード・インストゥルメント・カンパニー・インコーポレイテッド

Inventor： ホーパー，クレイラ・エリザベス ,  ラッシュブローク，ジョン・ゴードン

IPC: G01N21/64 ,  G01N21/76

CPC classification number: G01N21/6452 ,  G01N21/76 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833 ,  G01N2201/0866

公开(公告)号：WO2013148360A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/032517

申请日：2013-03-15

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： MERTZ, Jerome, Charles ,  FORD, Timothy, Nehiley ,  CHU, Kengyeh, Ken

IPC: G02B21/00 ,  G01N21/00 ,  G01N33/483

CPC classification number: G06T5/009 ,  A61B1/00009 ,  A61B1/00172 ,  A61B1/04 ,  G01N21/255 ,  G01N21/27 ,  G01N21/4795 ,  G01N2021/4797 ,  G01N2201/062 ,  G01N2201/0866 ,  G02B21/0012 ,  G02B21/06 ,  G02B21/14 ,  G06T2207/10068 ,  G06T2207/20208 ,  G06T2207/20221

Abstract: A method of creating a phase contrast image is provided. In some embodiments the method comprises illuminating the target region of a sample with a first light source to provide a first oblique back illumination of the target region of the sample, and detecting a first phase contrast image from light originating from the first light source and back illuminating the target region of the sample. In some embodiments the method further comprises illuminating the sample with a second light source to provide a second oblique back illumination of the target region of the sample, and detecting a second phase contrast image from light originating from the second light source and back illuminating the target region of the sample. In some embodiments a difference image of the target region of the sample is created by subtracting the second phase contrast image of the target region of the sample from the first phase contrast image of the target region of the sample. Apparatus for carrying out the methods are also provided. The methods and apparatus find use, for example, in endoscopy.

Abstract translation: 提供了创建相位对比图像的方法。 在一些实施例中，该方法包括用第一光源照射样品的目标区域，以提供样品的目标区域的第一倾斜背照射，以及从源自第一光源和背部的光检测第一相位对比图像 照亮样品的目标区域。 在一些实施例中，该方法还包括用第二光源照亮样品以提供样品的目标区域的第二倾斜背照射，以及从源自第二光源的光检测第二相位对比图像，并且反射照射目标 样品区域。 在一些实施例中，通过从样本的目标区域的第一相位对比图像中减去样本的目标区域的第二相位对比图像来创建样本的目标区域的差异图像。 还提供了用于执行方法的装置。 该方法和装置可用于例如内窥镜检查。

公开(公告)号：WO1993006459A1

公开(公告)日：1993-04-01

申请号：PCT/US1992007883

申请日：1992-09-17

Applicant: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

Inventor： IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  PORTER, Marc, D. ,  JONES, Thomas, P.

IPC: G01N21/31

CPC classification number: G01N21/7703 ,  G01J2001/1636 ,  G01N21/80 ,  G01N2021/3181 ,  G01N2021/772 ,  G01N2201/062 ,  G01N2201/084 ,  G01N2201/0866

Abstract: A dual wavelength optical sensor for measuring the optical characteristics of sensing films which are responsive to a particular quantity to be measured. The optical sensor includes a light source (16, 18) for producing light outputs at two distinct wavelengths and transmitting twin components of light to first and second outputs. A time-shared optical fiber (26) receives the two distinct wavelengths of light from the first output and carries the light on a time-shared basis to a sensor probe (14). A sample detector (30) receives the two distinct wavelengths of light transmitted from the thin sensing film. A reference detector (34) receives the two distinct wavelengths of light from the second output and monitors the output intensity of the light source. A signal processing system (35) combines the measurements of the optical characteristics of the thin sensing film in response to each of the two distinct wavelengths to provide measurements which account for changes in the optical properties of the thin sensing film.

Abstract translation: 一种双波长光学传感器，用于测量响应于要测量的特定量的感测膜的光学特性。 光学传感器包括用于产生两个不同波长的光输出的光源（16,18），并将光的双分量传输到第一和第二输出。 时分共享的光纤（26）从第一输出接收两个不同波长的光，并将时间共享的光传送到传感器探头（14）。 样本检测器（30）接收从薄感测膜传输的两种不同波长的光。 参考检测器（34）接收来自第二输出端的两个不同波长的光，并监视光源的输出强度。 信号处理系统（35）响应于两个不同波长中的每一个组合了薄感测膜的光学特性的测量，以提供考虑薄感测膜的光学性质变化的测量。