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    System for treating microvolume liquid
    2.
    发明专利
    System for treating microvolume liquid 有权
    微血管液体处理系统

    公开(公告)号：JP2008145434A

    公开(公告)日：2008-06-26

    申请号：JP2007307569

    申请日：2007-11-28

    Applicant: Packard Instr Co Inc ,  パッカード・インストルメント・カンパニー・インコーポレーテッドPackard Instrument Company Inc

    Inventor： PELC RICHARD E ,  CHIBUCOS NICHOLAS S ,  PAPEN ROELAND F ,  MEYER WILHELM J

    IPC: B67D3/00 ,  G01N35/10 ,  B01J4/02 ,  B01L3/02 ,  C40B60/14 ,  G01F1/48 ,  G01F3/00 ,  G01N1/00 ,  G01N35/00

    CPC classification number: G01N35/1065 ,  B01J2219/00378 ,  B01L3/0268 ,  C40B60/14 ,  G01F1/48 ,  G01F3/00 ,  G01N2035/00237 ,  G01N2035/1018 ,  G01N2035/1039 ,  G01N2035/1041

    Abstract: PROBLEM TO BE SOLVED: To provide a system handling treating liquid which can correctly measure microvolume of a transfer liquid that is to be dispensed, by measuring the corresponding change in pressure. SOLUTION: The microvolume liquid treating system 10 includes a microdispenser 16 employing a piezoelectric transducer attached to a glass capillary; a positive displacement pump 12 filling a transfer liquid into the microdispenser and sucking the transfer liquid from the microdispenser, controlling the pressure of the liquid of the system, and cleaning the microdispenser between liquid transfers; and a pressure sensor 14 for measuring the pressure of the liquid of the system and producing a corresponding electrical signal. The pressure signal is used to verify and measure the volume of the transfer liquid which is dispensed, and to perform automated calibration and diagnosis of the microdispenser. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：通过测量相应的压力变化，提供处理液体的系统，该处理液可以正确地测量待分配的转移液体的微量。 解决方案：微体积液体处理系统10包括采用附接到玻璃毛细管的压电换能器的微分离器16; 正排量泵12将转移液体填充到微型分配器中并从微型分配器吸取转移液体，控制系统的液体的压力，以及在液体转移之间清洁微量分散器; 以及压力传感器14，用于测量系统的液体的压力并产生相应的电信号。 压力信号用于验证和测量分配的转移液体的体积，并进行微分配器的自动校准和诊断。 版权所有（C）2008，JPO＆INPIT

    METHOD AND APPARATUS FOR MEASURING RADIOACTIVE DECAY
    7.
    发明申请
    METHOD AND APPARATUS FOR MEASURING RADIOACTIVE DECAY 审中-公开
    测量放射性衰变的方法和装置

    公开(公告)号：WO1985001584A1

    公开(公告)日：1985-04-11

    申请号：PCT/US1983001479

    申请日：1983-09-27

    Applicant: PACKARD INSTRUMENT COMPANY, INC.

    Inventor： PACKARD INSTRUMENT COMPANY, INC. ,  VALENTA, Robert, J.

    IPC: G01T01/208

    CPC classification number: G01T1/208 ,  G01T1/178 ,  G01T1/38

    Abstract: Method and apparatus for counting nuclear scintillations particularly the activity in a specimen containing tritium segregates the pulses which are emitted from a scintillator due on interaction with a nuclear particle from the pulses attributable to random noise. The system uses a single photomultiplier (12), the output of which is split among a two-path circuit (22, 32). A pulse height analyzer (46) provides an output when one path (32) has an integrated output signal of preselected amplitude when the other path (22) output has a preselected number of component photon response pulses occurring in a preselected period of time. The system is operable with many scintillation materials as long as the characteristic output from the scintillator is long relative to the duration of a random noise pulse. The preferred embodiment incorporates a solid scintillator although a liquid material may be substituted if the functional criteria are satisfied. Also discussed is the response of an apparatus in accordance with the present invention if some relatively high energy isotopes such as carbon-fourteen are tested.

    Abstract translation: 用于计数核闪烁的方法和装置，特别是含有氚的样品中的活性，从由于随机噪声引起的脉冲与核粒子的相互作用而分离从闪烁体发射的脉冲。 该系统使用单个光电倍增管（12），其输出在两路径电路（22,32）之间分配。 当另一个路径（22）输出具有在预选时段内出现的预选数量的分量光子响应脉冲时，脉冲高度分析器（46）提供输出，当一个路径（32）具有预选幅度的积分输出信号时。 只要来自闪烁体的特征输出相对于随机噪声脉冲的持续时间长，该系统可操作于许多闪烁材料。 如果满足功能标准，则优选实施例包含固体闪烁体，尽管液体材料可以被替代。 还讨论了如果测试了一些相对较高的能量同位素（如碳十四），则根据本发明的装置的响应。

    FLOW CELL FOR USE IN A FLOW SCINTILLATION ANALYZER
    8.
    发明申请
    FLOW CELL FOR USE IN A FLOW SCINTILLATION ANALYZER 审中-公开
    流动细胞用于流动分析分析仪

    公开(公告)号：WO1995012825A1

    公开(公告)日：1995-05-11

    申请号：PCT/US1994012036

    申请日：1994-10-21

    Applicant: PACKARD INSTRUMENT COMPANY, INC.

    Inventor： PACKARD INSTRUMENT COMPANY, INC. ,  BOROWSKI, Kenneth, J.

    IPC: G01T01/29

    CPC classification number: G01T1/003 ,  G01N30/62 ,  G01N2030/77

    Abstract: A flow cell (10) for use in a flow scintillation analyzer, the flow cell having first and second solid scintillators, a sample channeling element (18) for accepting a radioactive fluid sample containing positron emitting nuclides and directing the sample between a surface of the first solid scintillator and a surface of the second solid scintillator, and a first opaque, reflective coating (20) on the surface of the first solid scintillator.

    Abstract translation: 一种用于流动闪烁分析仪的流动池（10），该流动池具有第一和第二固态闪烁体，一个样品通道元件（18），用于接受含有正电子发射核素的放射性液体样品，并将样品引导至 第一固体闪烁体和第二固体闪烁体的表面，以及第一固体闪烁体表面上的第一不透明反射涂层。

    IMPROVED IMAGING METHOD AND APPARATUS
    9.
    发明申请
    IMPROVED IMAGING METHOD AND APPARATUS 审中-公开
    改进的成像方法和装置

    公开(公告)号：WO1995011461A1

    公开(公告)日：1995-04-27

    申请号：PCT/GB1994002301

    申请日：1994-10-20

    Applicant: CAMBRIDGE IMAGING LIMITED ,  PACKARD INSTRUMENT COMPANY ,  RUSHBROOKE, John, Gordon ,  HOOPER, Claire, Elizabeth ,  NEALE, William, Wray ,  ANSORGE, Richard, Eric

    Inventor： CAMBRIDGE IMAGING LIMITED ,  PACKARD INSTRUMENT COMPANY

    IPC: G01T01/28

    CPC classification number: G01T1/28 ,  G01T1/2928

    Abstract: A method of detecting the presence and position of radio isotope material in a sample is described comprising the steps of: exposing the sample to a phosphor, repetitively imaging the phosphor onto an image intensified CCD camera, scanning the camera CCD array and interrogating the charge pattern thereon following each exposure, performing measurements on the data signals obtained thereby to identify clusters of data values from adjacent regions of the array caused by light emitted by the image intensifier onto those regions and comparing the measurements with threshold values and parameter values so as to distinguish clusters resulting from light emitted as a result of radioactive decay events energising the phosphor, from other light producing events, computing the centroid of each cluster of data values identified as a radioactive decay event with reference to the camera array and storing the centroid coordinates in a memory together with the centroid coordinates of any other radioactive decay produced clusters identified during the same interrogation. Coordinates from each of a succession of interrogations of the same sample are stored in an accumulation store, which can be read out to give a list of recorded events and/or used to produce a display of the events superimposed on an outline of the sample. The samples are carried on fibre optic plates in conctact with the photocathode and event coordinates are stored in memory as they are detected, so that the dispaly is updated as the events occur. Low noise bi-alkali material is used for the photocathode and the CCD camera is operated in inverted mode to reduce noise.

    Abstract translation: 描述了一种检测样品中放射性同位素材料的存在和位置的方法，包括以下步骤：将样品暴露于磷光体，将磷光体重复成像到图像增强CCD相机上，扫描相机CCD阵列并询问电荷模式 在每次曝光之后，对由此获得的数据信号执行测量，从而识别由图像增强器发射到那些区域上的光引起的阵列的相邻区域的数据值簇，并将该测量与阈值和参数值进行比较，以区分 由于由于其他光产生事件激发磷光体的放射性衰变事件而发射的光而产生的光束，参考相机阵列计算被识别为放射性衰变事件的每个数据集群的质心并将质心坐标存储在 记忆以及任何其他放射天体的质心坐标 在同样的询问中确定了猝灭产生的簇。 来自相同样本的一系列询问中的每一个的坐标存储在累积存储器中，其可以被读出以给出记录事件的列表和/或用于产生叠加在样本轮廓上的事件的显示。 将样品携带在与光电阴极对应的光纤板上，并且事件坐标在被检测时存储在存储器中，使得随着事件发生而更新显示。 低噪声双碱性材料用于光电阴极，CCD相机以反相模式工作，以减少噪音。

    MICRODROP DISPENSING APPARATUS
    10.
    发明申请
    MICRODROP DISPENSING APPARATUS 审中-公开
    MICRODROP分配装置

    公开(公告)号：WO2002070999A2

    公开(公告)日：2002-09-12

    申请号：PCT/US2002/001916

    申请日：2002-01-23

    Applicant: PACKARD INSTRUMENT COMPANY, INC.

    Inventor： ZWEIFEL, Ronald, A. ,  HAHN, Christopher, M.

    IPC: G01F1/00

    CPC classification number: B01L3/0268 ,  B01L3/0262 ,  G01N35/1011 ,  G01N35/1016 ,  G01N2035/1039 ,  Y10T436/11

    Abstract: A method and apparatus for preventing or limiting damage to capillaries used to dispense microdrops measures the voltage produced by a piezoelectric transducer when the capillary contacts a solid surface or the phase shift occurring when the piezoelectric transducer is operated at its resonant frequency. After distinguishing the voltage created from such contact from the voltage produced from unrelated random sources, corrective action is taken, in one aspect by stopping the relative movement of the capillary and the surface being contacted. The method and apparatus may also be employed to determine the position of a solid or liquid surface.

    Abstract translation: 用于防止或限制用于分配微滴的毛细管损伤的方法和装置测量当毛细管接触固体表面时由压电换能器产生的电压或当压电换能器以其谐振频率操作时发生的相移。 在将这种接触产生的电压与不相关随机源产生的电压进行区分之后，采取纠正措施，一方面是通过停止毛细管和被接触表面的相对运动。 该方法和装置也可用于确定固体或液体表面的位置。

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