Device and method for analyzing samples
    11.
    发明申请
    Device and method for analyzing samples 有权
    用于分析样品的装置和方法

    公开(公告)号:US20050030541A1

    公开(公告)日:2005-02-10

    申请号:US10878895

    申请日:2004-06-28

    Abstract: The present invention relates to a device (1) and a method for determining parameters of fluid-containing samples (2) in a system (3) for individually irradiating the samples (2) with light (4) of a light source (5) in an essentially vertical irradiation direction (6). In this case, this system (3) includes a detector (7) for measuring the light (8) coming from a single sample, and this detector (7) has a detection direction (9′), which lies on an optical axis (9) that is essentially parallel to the optical axis (6) of the light source (5). This device (1) includes at least one reflective surface (10), using which the light (4) coming essentially vertically out of the light source (5) may be at least partially deflected in an essentially horizontal irradiation direction (11). The device according to the present invention and the method according to the present invention are distinguished in that the detection direction (9′) of the detector (7)—for measuring the individual light (8) coming from a single sample (2)—is positioned at an angle to the optical axis of the light (4) irradiating the sample (2) in such a way that only the light (8) coming from the individual sample (2), but not this light (4), reaches the detector (7).

    Abstract translation: 本发明涉及一种用于在系统(3)中确定用于用光源(5)的光(4)单独照射样品(2)的系统(3)中的含液样品(2)的参数的装置(1)和方法, 在基本垂直的照射方向(6)上。 在这种情况下,该系统(3)包括用于测量来自单个样品的光(8)的检测器(7),并且该检测器(7)具有位于光轴(9')上的检测方向(9' 9),其基本上平行于光源(5)的光轴(6)。 该装置(1)包括至少一个反射表面(10),基本上垂直离开光源(5)的光线可以在基本上水平的照射方向(11)上至少部分地偏转。 根据本发明的装置和根据本发明的方法的特征在于,用于测量来自单个样品(2)的单个光(8)的检测器(7)的检测方向(9') - 被定位成与照射样品(2)的光(4)的光轴成一定角度,使得仅来自各个样品(2)的光(8)而不是该光(4)到达 检测器(7)。

    MASKING TO PREVENT OVEREXPOSURE AND LIGHT SPILLAGE IN MICROARRAY SCANNING
    12.
    发明申请
    MASKING TO PREVENT OVEREXPOSURE AND LIGHT SPILLAGE IN MICROARRAY SCANNING 审中-公开
    阻止在微波扫描中防止过度曝光和光泄漏

    公开(公告)号:WO2007070277A2

    公开(公告)日:2007-06-21

    申请号:PCT/US2006/046286

    申请日:2006-12-04

    Inventor: CHU, Daniel Y.

    CPC classification number: G01N21/253 G01N2201/0446 G01N2201/1042

    Abstract: Scanning of a microarray is performed through a mask that exposes a plurality, but not all, of the sites of the microarray, and either the mask is movable relative to the microarray or the microarray is movable relative to the mask, or both. The mask is useful as a means of restricting the illumination of sites on the microarray to those that can be illuminated while the scan head is traveling at a steady, target velocity, blocking the passage of light between the scan head and the microarray at those points in the scan head trajectory where the scan head is either accelerating or decelerating. The mask is also useful for reducing background noise in the microarray image by preventing light spillage to sites adjacent to those being scanned.

    Abstract translation: 微阵列的扫描通过暴露微阵列的多个但不是全部的掩模进行,并且掩模可以相对于微阵列移动,或者微阵列相对于掩模或两者均可移动。 该掩模可用作将扫描头以稳定的目标速度行进的情况下将微阵列上的部位的照明限制于可被照亮的装置,阻止在那些点处扫描头和微阵列之间的光通过 在扫描头轨迹中扫描头正在加速或减速。 该掩模也可用于通过防止光泄漏到与被扫描的位置相邻的位置来减少微阵列图像中的背景噪声。

    System and method for multimode imaging
    15.
    发明授权
    System and method for multimode imaging 失效
    多模成像系统和方法

    公开(公告)号:US07567346B2

    公开(公告)日:2009-07-28

    申请号:US11363938

    申请日:2006-03-01

    Abstract: A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved elative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

    Abstract translation: 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术将至少一个样品移动到光学系统。 该方法包括以下步骤:(1)选择成像系统的操作模式; (2)从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; (3)使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和(4)用检测器选择性地读取像素。

    Device and method for analyzing samples
    16.
    发明授权
    Device and method for analyzing samples 有权
    用于分析样品的装置和方法

    公开(公告)号:US07202945B2

    公开(公告)日:2007-04-10

    申请号:US10878895

    申请日:2004-06-28

    Abstract: The present invention relates to a device (1) and a method for determining parameters of fluid-containing samples (2) in a system (3) for individually irradiating the samples (2) with light (4) of a light source (5) in an essentially vertical irradiation direction (6). In this case, this system (3) includes a detector (7) for measuring the light (8) coming from a single sample, and this detector (7) has a detection direction (9′), which lies on an optical axis (9) that is essentially parallel to the optical axis (6) of the light source (5). This device (1) includes at least one reflective surface (10), using which the light (4) coming essentially vertically out of the light source (5) may be at least partially deflected in an essentially horizontal irradiation direction (11). The device according to the present invention and the method according to the present invention are distinguished in that the detection direction (9′) of the detector (7)—for measuring the individual light (8) coming from a single sample (2)—is positioned at an angle to the optical axis of the light (4) irradiating the sample (2) in such a way that only the light (8) coming from the individual sample (2), but not this light (4), reaches the detector (7).

    Abstract translation: 本发明涉及一种用于在系统(3)中确定用于用光源(5)的光(4)单独照射样品(2)的系统(3)中的含液样品(2)的参数的装置(1)和方法, 在基本垂直的照射方向(6)上。 在这种情况下,该系统(3)包括用于测量来自单个样品的光(8)的检测器(7),并且该检测器(7)具有位于光轴(9')上的检测方向(9' 9),其基本上平行于光源(5)的光轴(6)。 该装置(1)包括至少一个反射表面(10),基本上垂直离开光源(5)的光线可以在基本上水平的照射方向(11)上至少部分地偏转。 根据本发明的装置和根据本发明的方法的特征在于,用于测量来自单个样品(2)的单个光(8)的检测器(7)的检测方向(9') - 被定位成与照射样品(2)的光(4)的光轴成一定角度,使得仅来自各个样品(2)的光(8)而不是该光(4)到达 检测器(7)。

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