公开(公告)号：US5422926A

公开(公告)日：1995-06-06

申请号：US184271

申请日：1994-01-21

Applicant: Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Mark T. Dinsmore

Inventor： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Mark T. Dinsmore

IPC: A61B19/00 ,  A61N5/10 ,  H01B11/22 ,  H01J35/00 ,  H01J35/06 ,  H01J35/08 ,  H01J35/14 ,  H01J35/30 ,  H01J35/32 ,  H05G1/00 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

CPC classification number: A61N5/1001 ,  A61B90/11 ,  H01J35/065 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61B2090/101 ,  A61N2005/1005 ,  H01J2201/342

Abstract: The present invention is directed to an x-ray source for irradiating a volume in accordance with a predetermined dose distribution. The source comprises a housing, an elongated tubular probe, and a target assembly. The housing encloses an electron beam source and includes elements for generating an electron beam along a beam path. The tubular probe extends along a central axis from the housing about the beam path. The target assembly extends along the central axis and is adapted for coupling to the end of the probe distal from the housing. The target assembly includes a target element, a probe tip assembly, and a variable transmission shield. The target element is positioned in the beam path. The target element is adapted to emit x-rays in response to electrons incident thereon from the beam. The probe tip assembly and associated control electronics include elements for positioning the target element in the beam path, and is substantially x-ray transparent. The variable transmission shield is positioned on an outer surface of the probe tip assembly, and is adapted to control the position of the isodose surfaces of the x-rays emitted from the target and passing through the probe tip assembly.

Abstract translation: 本发明涉及一种用于根据预定剂量分布照射体积的x射线源。 源包括壳体，细长管状探针和目标组件。 壳体包围电子束源并且包括用于沿着光束路径产生电子束的元件。 管状探针沿着中心轴线从壳体围绕光束路径延伸。 目标组件沿着中心轴线延伸并且适于联接到远离壳体的探针的端部。 目标组件包括目标元件，探针尖端组件和可变透射屏蔽。 目标元件位于光束路径中。 目标元件适于响应于从光束入射到其上的电子而发射X射线。 探针尖端组件和相关联的控制电子器件包括用于将目标元件定位在光束路径中的元件，并且基本上是x射线透明的。 可变透射屏蔽定位在探针头组件的外表面上，并且适于控制从靶发射并穿过探针头组件的X射线的等剂量表面的位置。

公开(公告)号：US4749906A

公开(公告)日：1988-06-07

申请号：US54507

申请日：1987-05-27

Applicant: Duc T. Tran ,  Georges Faillon

Inventor： Duc T. Tran ,  Georges Faillon

IPC: H01J3/02 ,  H01J23/04 ,  H01J25/04 ,  H01J25/02

CPC classification number: H01J23/04 ,  H01J25/04 ,  H01J3/021 ,  H01J2201/342

Abstract: The invention relates to multiple beam lasertrons. The n (n: integer greater than 1) electron beams of the lasertron are obtained from the same laser beam from which n secondary laser beams are extracted, by occultation, which are deflected respectively towards the n photocathodes of the lasertron.

Abstract translation: 本发明涉及多束激光雷达。 从通过掩蔽得到n个次级激光束的相同的激光束获得激光雷达的n（n：整数大于1）的电子束，它们分别偏转到lasertron的n个光电阴极。

公开(公告)号：EP0740847B1

公开(公告)日：2003-10-01

申请号：EP95908611.7

申请日：1995-01-19

Applicant: PHOTOELECTRON CORPORATION

Inventor： HARTE, Kenneth, J. ,  OETTINGER, Peter, E.

IPC: H01J35/08 ,  H01J35/32 ,  A61N5/10

CPC classification number: A61N5/1001 ,  A61B90/11 ,  A61B2090/101 ,  A61N2005/1005 ,  H01J35/065 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H01J2201/342 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

Abstract: This invention is directed to an x-ray source comprising a housing (12), a power supply (12A), an elongated tubular probe (14), a target assembly (26), and a beam steering assembly (29). The housing encloses an electron beam source (22), and has elements for generating an electron beam along a beam path. The power supply (12A) is programmable to control the voltage, current and timing of an electron beam. The elongated tubular probe (14) extends along a central axis from the housing (12) about the beam path. The target assembly (26) extends along the central axis and is adapted for coupling to end of the probe (14) distal from the housing (12). The target assembly (26) includes target element (26A) positioned along the beam path, wherein the target element (26A) is adapted to emit x-rays in a predetermined spectral range in response to incident electrons. The beam steering assembly (29) includes a deflection element (30), a feedback network (31) and a deflection controller (144). The deflection element (30) deflects the beam from a nominal axis to a selected surface region on the target element (26) in response to a deflection control signal. The feedback network (31) includes deflection sensing elements for sensing the deflection of the beam and elements for generating a feedback signal representative thereof.

公开(公告)号：EP0770258B1

公开(公告)日：2001-10-24

申请号：EP95925598.5

申请日：1995-07-11

Applicant: PHOTOELECTRON CORPORATION

Inventor： SMITH, Donald, O. ,  SLISKI, Alan, P. ,  HARTE, Kenneth, J.

IPC: G21K5/00 ,  G21K5/10

CPC classification number: A61N5/1001 ,  A61N2005/1005 ,  G21K5/04 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H01J2201/342 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

Abstract: The present invention is directed to an x-ray source (10) for irradiating a surface defining a body cavity. The source comprises a housing (12), an elongated tubular probe (14), a target assembly (26), and an inflatable balloon (410). The housing (12) encloses an electron beam source (22) and includes elements (23) for generating an electron beam along a beam path. The tubular probe (14) extends along a central axis from the housing (12) about the beam path. The target assembly (26) extends along the central axis and is coupled to the probe distal end. The target assembly (26) includes a target element (26A, 26B) adapted to emit x-rays in response to electrons incident thereon. The probe tip assembly and associated control electronics include elements for positioning the target element in the beam path, and is substantially x-ray transparent. The balloon (410) affixed to the distal end is inflatable so as to be inflated to stretch the cavity to a shape, thus allowing a uniform delivery of dose of radiation to the surface defining a body cavity.

公开(公告)号：US20130341527A1

公开(公告)日：2013-12-26

申请号：US14003030

申请日：2012-03-15

Applicant: Jean Berney

Inventor： Jean Berney

IPC: G21K5/04

CPC classification number: G21K5/04 ,  H01J37/073 ,  H01J2201/342 ,  H01J2237/06333 ,  H01J2237/065

Abstract: A method suitable for preparing a specimen for inspection, the method comprising the steps of: irradiating a photocathode so that the photocathode emits electrons from a surface of the photocathode, wherein the emitted electrons each follow a trajectory, and the trajectories of the electrons are such that they can be extrapolated to intersect at a region within the photocathode, the region defining a virtual source, and wherein the photocathode comprises a rounded tip which has a radius of curvature; configuring the emitted electrons so that they form an electron beam; focusing the electron beam onto a specimen to form an image of the virtual source on the specimen. There is further provided a corresponding electron beam apparatus.

Abstract translation: 一种适于制备用于检查的样品的方法，所述方法包括以下步骤：照射光电阴极，使得光电阴极从光电阴极的表面发射电子，其中发射的电子各自遵循轨迹，并且电子的轨迹为 它们可以外推到在光电阴极内的区域相交，所述区域限定虚拟源，并且其中所述光电阴极包括具有曲率半径的圆形尖端; 配置发射的电子，使它们形成电子束; 将电子束聚焦到样本上以形成样本上的虚拟源的图像。 还提供了相应的电子束装置。

公开(公告)号：US5768337A

公开(公告)日：1998-06-16

申请号：US688468

申请日：1996-07-30

Applicant: Weston A. Anderson

Inventor： Weston A. Anderson

IPC: H01J35/06 ,  H01J35/26 ,  H01J35/14

CPC classification number: H01J35/24 ,  H01J35/065 ,  H01J2201/342 ,  H01J2235/1266 ,  H01J2235/162

Abstract: An X-ray tube has an anode and a photocathode inside a vacuum envelope and an electron multiplier is disposed between them. Such an electron multiplier may be a plurality of sequentially disposed dynodes or a microchannel plate. Because of the secondary electron emission from such an electron multiplier, a higher-power radiation is obtained without requiring a high optical power level to generate photoelectrons. The vacuum envelope may be of a rotary type with the anode and photocathode having annular regions.

Abstract translation: X射线管在真空外壳内具有阳极和光电阴极，并且在它们之间设置电子倍增器。 这种电子倍增器可以是多个顺序设置的倍增电极或微通道板。 由于来自这种电子倍增器的二次电子发射，获得更高功率的辐射而不需要高的光功率电平来产生光电子。 真空外壳可以是具有阳极和光电阴极具有环形区域的旋转型。

公开(公告)号：US5452720A

公开(公告)日：1995-09-26

申请号：US104338

申请日：1993-08-09

Applicant: Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Peter J. Biggs ,  John F. Beatty

Inventor： Donald O. Smith ,  Alan P. Sliski ,  Kenneth J. Harte ,  Peter J. Biggs ,  John F. Beatty

IPC: A61N5/10 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61B6/12 ,  A61M36/00

CPC classification number: A61N5/1001 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61N2005/1005 ,  H01J2201/342

Abstract: A method of treating brain tumors in a patient, comprising the steps of: identifying and locating a brain tumor in vivo by affixing a stereotactic frame to the head of the patient, performing a computer tomographic (CT) scan of the skull of the patient to determine the location, size, and shape of the tumor with respect to the stereotactic frame, performing a biopsy by inserting an extraction tool along a path measured with respect to the frame to the tumor location, extracting a tissue from the location, removing the needle and the extracted tissue and analyzing the tissue; implanting at least a portion of an adjustable x-ray radiation source in the patient proximate the tumor, the adjustable radiation source including an electron beam source outside the head of the patient, and directing an electron beam produced by the source outside the head of the patient along the path to the location; and controlling the source to generate an x-ray radiation pattern characterized by a spatial and temporal distribution, to selectively irradiate the tumor.

Abstract translation: 一种治疗患者脑肿瘤的方法，包括以下步骤：通过将立体定向框架固定在患者的头部来识别和定位脑肿瘤，对患者的头骨进行计算机断层扫描（CT）扫描 确定相对于立体定向框架的肿瘤的位置，大小和形状，通过沿着相对于框架测量的路径将提取工具插入到肿瘤位置进行活检，从该位置提取组织，移除针 和提取的组织并分析组织; 在靠近肿瘤的患者中植入至少一部分可调节X射线辐射源，所述可调节辐射源包括位于患者头部外部的电子束源，并且将源头产生的电子束引导到患者头部外部 患者沿着路径到位置; 并且控制源以产生以空间和时间分布为特征的X射线辐射图，以选择性地照射肿瘤。

公开(公告)号：US5428658A

公开(公告)日：1995-06-27

申请号：US184296

申请日：1994-01-21

Applicant: Peter E. Oettinger ,  Kenneth J. Harte

Inventor： Peter E. Oettinger ,  Kenneth J. Harte

IPC: A61B19/00 ,  A61N5/10 ,  H01B11/22 ,  H01J35/00 ,  H01J35/06 ,  H01J35/08 ,  H01J35/14 ,  H01J35/30 ,  H01J35/32 ,  H05G1/00 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

CPC classification number: A61N5/1001 ,  A61B90/11 ,  H01J35/065 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61B2090/101 ,  A61N2005/1005 ,  H01J2201/342

Abstract: This invention is directed to an x-ray source comprising a power supply, a flexible fiber optic cable assembly, a light source, and a target assembly. The power supply includes a first terminal and a second terminal, and elements for establishing an output voltage between the first terminal and the second terminal. The flexible fiber optical cable assembly has an originating end and a terminating end, and includes a fiber optical element extending from the originating end to the terminating end. The cable is adapted for transmitting light incident on the originating end to the terminating end. The light source includes elements for generating a beam of light at and directed to the originating end of the fiber optical cable assembly. The target assembly is affixed to the terminating end of the fiber optical cable assembly and is electrically coupled to the power supply by way of the first terminal and the second terminal. The target assembly includes elements for emitting x-rays in a predetermined spectral range, in response to light transmitted to the terminating end.

Abstract translation: 本发明涉及一种包括电源，柔性光缆组件，光源和目标组件的x射线源。 电源包括第一端子和第二端子，以及用于在第一端子和第二端子之间建立输出电压的元件。 柔性光纤光缆组件具有起始端和终止端，并且包括从起始端延伸到终端的光纤元件。 电缆适用于将入射在起始端的光线发射到终端。 光源包括用于在光纤光缆组件的起始端处产生光束并被引导到光纤光缆组件的始端的元件。 目标组件固定到光纤光缆组件的终端，并通过第一终端和第二终端电耦合到电源。 目标组件包括响应于传输到终端的光在预定光谱范围内发射X射线的元件。

公开(公告)号：US5049753A

公开(公告)日：1991-09-17

申请号：US549885

申请日：1990-06-28

Applicant: Larry D. Flesner

Inventor： Larry D. Flesner

IPC: H01J3/02 ,  H01J27/00 ,  H01J37/073 ,  H01J37/248 ,  H02J17/00 ,  H05H5/00

CPC classification number: H02J17/00 ,  H01J27/00 ,  H01J3/021 ,  H01J37/073 ,  H01J37/248 ,  H05H5/00 ,  H01J2201/342

Abstract: A charged particle control apparatus provides very high voltage particle beams. One or more photocell arrays provide bias voltages for beam accelerating stages. The arrays are made from a number of microfabricated photocells connected in series to produce a voltage output that is the sum of the voltages from the individual cells. Arrays of each stage are connected in series to produce a cumulative stage voltage that is applied to an accelerating electrode made part of the stage.These accelerating stages are disposed within a transparent vacuum chamber and are spaced from a charged particle source stage disposed near one end of the chamber. This charged particle source stage includes an emission source such as a photocathode. The photo arrays of the accelerating stages are connected in series to produce a potential that is applied to the particle source stage.Optical power illuminates the stages to generate desired voltage biases to the accelerating electrodes. A light source is used to excite the photocathode when this emission source is used. Electrons from the emission source are accelerated by the accelerating electrodes and are emitted from the chamber which is typically conjoined with other apparatus.By utilizing photocell arrays to generate beam current and accelerating biases, as well as a photocathode for providing a source of electrons, the apparatus of the invention is completely optically isolated thereby requiring no direct electrical connections to the apparatus even though multiple accelerating stages are used to facilitate the achievement of very high voltage particle beams.

Abstract translation: 带电粒子控制装置提供非常高电压的粒子束。 一个或多个光电池阵列为光束加速阶段提供偏置电压。 阵列由多个串联连接的微细胞光电池制成，以产生电压输出，该电压输出是来自各个单元的电压之和。 每个级的阵列串联连接以产生累加级电压，该电压施加到制成该级的一部分的加速电极。 这些加速阶段设置在透明真空室内并与设置在室的一端附近的带电粒子源级间隔开。 该带电粒子源级包括诸如光电阴极的发射源。 加速级的光阵列被串联连接以产生施加到粒子源级的电位。 光功率照亮阶段以产生对加速电极的期望的电压偏压。 当使用该发射源时，使用光源来激发光电阴极。 来自发射源的电子被加速电极加速并且从通常与其他装置结合的室发射。 通过利用光电池阵列产生射束电流和加速偏置，以及用于提供电子源的光电阴极，本发明的装置是完全光学隔离的，因此即使使用多个加速阶段也不需要与设备的直接电连接 有助于实现非常高电压的粒子束。

公开(公告)号：JP5849108B2

公开(公告)日：2016-01-27

申请号：JP2013558428

申请日：2012-03-15

Applicant: エコール ポリテクニック フェデラル ドゥ ローザンヌ (ウペエフエル) ,  ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Inventor： ベルネイ,ジャン

IPC: H01J37/063 ,  H01J37/21 ,  H01J37/073

CPC classification number: G21K5/04 ,  H01J37/073 ,  H01J2201/342 ,  H01J2237/06333 ,  H01J2237/065