公开(公告)号：WO1997043950A1

公开(公告)日：1997-11-27

申请号：PCT/GB1997001388

申请日：1997-05-21

Applicant: MOOR INSTRUMENTS LIMITED ,  BOGGETT, David ,  HUANG, Xiabing

Inventor： MOOR INSTRUMENTS LIMITED

IPC: A61B05/026

CPC classification number: A61B5/0261

Abstract: An apparatus for measuring and imaging blood perfusion in tissue comprises a monochromatic laser light source (A2); means for shaping the laser light beam; means for irradiating a section of the surface of the tissue (A4) with the laser light beam; means for collecting (A5, A1, A8) light scattered from the irradiated section; an image sensor (A3) comprising a plurality of photodetectors, each photodetector of the sensor being able to receive collected light from a predetermined sub area of the section of the tissue surface and produce a corresponding electrical output signal linearly related to the detected instantaneous laser light intensity; means for processing (4) the electrical output signals from the plurality of photodetectors; means for calculating the average Doppler frequency shift for each sub area from which scattered light is detected; means for producing an image (5) of the blood perfusion in the tissue section irradiated from the processed output signals; and an image display means. The apparatus enables fast tissue blood perfusion imaging to sub second times.

Abstract translation: 用于测量和成像组织中血液灌注的装置包括单色激光源（A2）; 用于成形激光束的装置; 用于用激光照射组织（A4）表面的一部分的装置; 用于从照射部分收集（A5，A1，A8）光的装置; 包括多个光电检测器的图像传感器（A3），所述传感器的每个光电检测器能够接收来自所述组织表面的所述部分的预定子区域的收集的光，并产生与所检测的瞬时激光线性相关的对应的电输出信号 强度; 用于处理（4）来自所述多个光电检测器的电输出信号的装置; 用于计算检测散射光的每个子区域的平均多普勒频移的装置; 用于产生从经处理的输出信号照射的组织部分中的血液灌注图像（5）的装置; 和图像显示装置。 该装置能够快速组织血液灌注成像次要次。

公开(公告)号：WO1992012668A1

公开(公告)日：1992-08-06

申请号：PCT/US1992000618

申请日：1992-01-24

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  BAILIN, Steven, J. ,  WILSON, Robert, F.

IPC: A61B05/026

CPC classification number: A61B8/06 ,  A61B8/12 ,  A61B8/445

Abstract: A device and method for measuring fluid flow within a vessel having fluctuating elastic walls, such as, for example, an artery. The device includes catheter (22); an internal stabilizer or frame (30) for establishing an invariant cross-section in the vessel wall; and a fluid velocity detecting system, such as, for example, a Doppler crystal transducer (32). The method for measuring includes the steps of stabilizing the vessel wall and measuring the velocity of fluid passing through the stabilized cross-section of the vessel wall. A method of treating and a method of diagnosing vascular disease by employing the device of this invention is also part of the invention.

公开(公告)号：WO1995026677A1

公开(公告)日：1995-10-12

申请号：PCT/EP1995001171

申请日：1995-03-29

Applicant: PACESETTER AB ,  FEREK-PETRIC, Bozidar ,  BREYER, Branko

Inventor： PACESETTER AB

IPC: A61B05/026

CPC classification number: A61N1/36514 ,  A61B5/026 ,  A61N1/36571

Abstract: An intracardiac blood flow velocity measurement device comprises a catheter means (10) adapted to be inserted through a blood vessel (31) into the heart, at least two electrodes (12, 13) made of two different biocompatible materials being mounted onto the catheter means (10) at a detecting position which is located in the desired detecting area (35) when said catheter means (10) is inserted into the heart for detecting the blood flow velocity, wherein at least one of said electrodes (first electrode 13) being formed as a polarizable electrode and being arranged in said detecting position and another one (second electrode 12) being located in an axially spaced relationship to said first electrode (13). The variation of overvoltage or of galvanic voltage is used as blood flow velocity signal.

Abstract translation: 心内血流速度测量装置包括适于插入通过血管（31）进入心脏的导管装置（10），由两种不同生物相容性材料制成的至少两个电极（12,13）被安装在导管装置 （10）在所述导管装置（10）插入心脏中以检测血流速度时位于所需检测区域（35）中的检测位置，其中至少一个所述电极（第一电极13）为 形成为可极化电极并布置在所述检测位置，另一个（第二电极12）与​​所述第一电极（13）轴向间隔开。 过电压或电流电压的变化用作血流速度信号。

公开(公告)号：WO1995013741A1

公开(公告)日：1995-05-26

申请号：PCT/US1994013134

申请日：1994-11-14

Applicant: PACESETTER, INC.

Inventor： PACESETTER, INC. ,  MOUCHAWAR, Gabriel ,  McCLURE, Kelly, H. ,  MOBERG, Sheldon, B.

IPC: A61B05/026

CPC classification number: A61N1/36542 ,  A61N1/3956

Abstract: A processing system (50) and method are provided for deriving an improved hemodynamic indicator from cardiac wall acceleration signals. The cardiac wall acceleration signals are provided by a cardiac wall motion sensor (52) that responds to cardiac mechanical activity. The cardiac wall acceleration signals are integrated over time by an integrator circuit (56) to derive cardiac wall velocity signals, which are further integrated over time by an integrator circuit (60) to derive cardiac wall displacement signals. The cardiac wall displacement signals correlate to known hemodynamic indicators, and are shown to be strongly suggestive of hemodynamic performance. An implantable cardiac stimulating device (300) which uses cardiac wall displacement signals to detect and discriminate cardiac arrhythmias is also provided.

Abstract translation: 提供了一种处理系统（50）和方法，用于从心脏壁加速度信号导出改进的血液动力学指标。 心脏壁加速度信号由响应于心脏机械活动的心脏壁运动传感器（52）提供。 心脏壁加速度信号由积分器电路（56）随时间被积分以导出心脏壁速度信号，随着时间的推移，积分器电路（60）进一步积分以产生心脏壁位移信号。 心脏壁位移信号与已知的血液动力学指标相关，并且显示出强烈地提示血流动力学性能。 还提供了使用心脏壁位移信号来检测和区分心律不齐的可植入心脏刺激装置（300）。

公开(公告)号：WO1993003667A1

公开(公告)日：1993-03-04

申请号：PCT/SE1992000570

申请日：1992-08-21

Applicant: NILSSON, Gert

IPC: A61B05/026

CPC classification number: G01P5/26 ,  A61B5/0261

Abstract: The invention relates to a method and to a system for reducing the distance-dependent amplification factor when measuring fluid flow movements with the aid of an image-producing laser-Doppler technique, in particular when measuring blood perfusion through tissue. A laser beam source (1) directs a laser beam (2) onto a measurement object (5), which scatters and reflects the beam (2). The reflected light is received by a detector (9) which senses the broadening in frequency caused by the Doppler effect. Means, preferably in the form of one or more lenses (12: 15, 16) are placed in the path of the beam (2) and are intended to maintain constant the number of coherence areas on the detecting surface of the detector and independent of the distance between detector and measurement object.

Abstract translation: 本发明涉及一种方法和系统，用于借助于图像产生激光多普勒技术，特别是当测量通过组织的血液灌注来测量流体流动时，减小距离相关的放大因子。 激光束源（1）将激光束（2）引导到测量对象（5）上，测量对象（5）散射并反射光束（2）。 反射光被检测器（9）接收，检测器（9）感测由多普勒效应引起的频率变宽。 优选以一个或多个透镜（12：15,16）的形式放置在光束（2）的路径中的装置，旨在保持检测器的检测表面上的相干区域的数量不变，并且独立于 探测器与测量对象之间的距离。

公开(公告)号：WO1992015239A1

公开(公告)日：1992-09-17

申请号：PCT/US1992000194

申请日：1992-01-13

Applicant: KENSEY NASH CORPORATION

Inventor： KENSEY NASH CORPORATION ,  CHO, Young ,  KENSEY, Kenneth

IPC: A61B05/026

CPC classification number: A61B5/02035 ,  A61B5/0275 ,  A61B5/15003 ,  A61B5/153 ,  A61B5/157 ,  A61B5/6848 ,  A61B5/6876

Abstract: An apparatus (20) for determining the viscosity of the whole blood of a living being comprises a monitor unit (22) arranged to be coupled to a blood vessel (26) for monitoring the transit time of a portion of the blood when it flows through the vessel. In one embodiment the sampling unit (22) is implantable in the blood vessel (26) and uses a pair of transducers (34, 36) for measuring a pressure drop within the vessel, a device (42) for determining the instantaneous blood velocity therein, and circuitry (24) for calculating the blood viscosity. In another embodiment a sampling unit includes a needle (110) and associated syringe-like body (108), plural pairs of pressure transducers (120-122 and 126-128) and associated calculation circuitry (40) to determine the pressure drop at different flow rates so that blood viscosity can be calculated therefrom.

Abstract translation: 一种用于确定生物的全血的粘度的装置（20）包括：监测单元（22），其布置成联接到血管（26），用于监测血液流过一部分血液的通过时间 船只。 在一个实施例中，采样单元（22）可植入血管（26）中并且使用一对换能器（34,36）来测量血管内的压降，用于确定血管内瞬时血液速度的装置（42） 以及用于计算血液粘度的电路（24）。 在另一个实施例中，采样单元包括针（110）和相关联的注射器状体（108），多对压力换能器（120-122和126-128）和相关联的计算电路（40），以确定不同的压力 流速，从而可以计算血液粘度。

公开(公告)号：WO1998008435A1

公开(公告)日：1998-03-05

申请号：PCT/FR1997001536

申请日：1997-08-29

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ,  DURET, Denis

Inventor： COMMISSARIAT A L'ENERGIE ATOMIQUE

IPC: A61B05/026

CPC classification number: G01B7/13 ,  A61B5/027 ,  A61B5/0295 ,  A61B5/1076 ,  A61N1/36514 ,  G01F17/00

Abstract: The invention concerns a method for measuring at least one dimension of a conductive volume, in which a measuring sensor (10) is placed inside a cavity present in a conductive or non-conductive homogeneous body (11), this cavity having large dimensions and high resistivity compared to the respective dimensions and resistivity of the volume to be measured, the sensor having features which vary according to the immediate volume in which it is found, this medium being a medium with electromagnetic losses. The invention also concerns a device for implementing this method.

Abstract translation: 本发明涉及一种用于测量导电体积的至少一个维度的方法，其中将测量传感器（10）放置在存在于导电或非导电均质体（11）中的空腔内，该空腔具有大的尺寸和高度 电阻率与要测量的体积的相应尺寸和电阻率相比，传感器具有根据其发现的即时体积而变化的特征，该介质是具有电磁损耗的介质。 本发明还涉及一种用于实现该方法的装置。

公开(公告)号：WO1996028088A3

公开(公告)日：1996-09-19

申请号：PCT/US1996003092

申请日：1996-03-08

Applicant: VNUS MEDICAL TECHNOLOGIES, INC.

Inventor： VNUS MEDICAL TECHNOLOGIES, INC. ,  LAUFER, Michael, D. ,  MILLER, Gary, H.

IPC: A61B05/026

公开(公告)号：WO1992021284A1

公开(公告)日：1992-12-10

申请号：PCT/US1992004542

申请日：1992-06-02

Applicant: APPLIED BIOMETRICS, INC.

Inventor： APPLIED BIOMETRICS, INC. ,  CZAR, Carl, T. ,  MIKOLAJCZYK, Edward, J.

IPC: A61B05/026

CPC classification number: A61B8/06 ,  A61B8/12

Abstract: A removable implanted device (10) is provided which monitors the blood flow in a vessel (22) and can be removed through the insertion wound (20) without additional surgery. The device has an elongated probe body (12) which contains a Doppler-type ultrasonic transducer (40) attached to the probe body at an angle so as to enable monitoring of blood flow when attached to the vessel (22). The device has a flexible tube (18) which extends out of the body through the insertion wound (20). The device is held in place against the vessel (22) by sutures (38) which are secured to the probe body (12) by a suture attachment wire (24, 26) which may be bent or looped to form two substantially equal lengths (24, 26). Alternate embodiments use a release wire (62) or a balloon (70) to secure the sutures (38) to the probe body (12).

公开(公告)号：WO1992015240A1

公开(公告)日：1992-09-17

申请号：PCT/US1992001429

申请日：1992-02-20

Applicant: KENSEY NASH CORPORATION

Inventor： KENSEY NASH CORPORATION ,  CHO, Young ,  KENSEY, Kenneth

IPC: A61B05/026

CPC classification number: A61B5/02035 ,  A61B5/026 ,  A61B5/0275

Abstract: An apparatus (20) for determining the instantaneous shear stress produced on a portion of the inner wall of a blood vessel (26) by the blood flow through that vessel comprises a tube (28) arranged longitudinally within the vessel (26) which has a pair of longitudinally spaced pressure transducers (34, 36) for measuring the pressure drop therein. Electronic circuitry (24) receives a signal from a sampling unit (22), and a signal indicative of the inner diameter of the blood vessel, and a signal indicative of the distance between the longitudinally spaced pressure transducers (34, 36) to calculate the instantaenous shear stress.

Abstract translation: 一种用于确定通过血管通过该容器的血流在血管内壁的一部分上产生的瞬时剪切应力的装置（20）包括纵向排列在容器（26）内的管（28），该管 一对纵向间隔的压力传感器（34,36），用于测量其中的压降。 电子电路（24）接收来自采样单元（22）的信号和指示血管内径的信号，以及指示纵向间隔开的压力传感器（34,36）之间的距离的信号，以计算出 瞬时剪切应力。