公开(公告)号：WO1991016852A1

公开(公告)日：1991-11-14

申请号：PCT/SE1991000338

申请日：1991-05-08

Applicant: CHISCAN AB ,  ROS, Mikael ,  STRIDSBERG, Lennart

Inventor： CHISCAN AB

IPC: A61B05/055

CPC classification number: G01R33/465

Abstract: A method is proposed for detecting cancer and particularly malign tumors in a person by using the NMR spectrum of blood plasma. In a recorded spectrum the resonances are determined and for these values mathematically defineable properties are calculated such as in the simplest case the height of the resonance and the value of the width of the resonance at half height. Advantageously at least two different mathematically defineable properties are used and the corresponding values are considered as entered in a multidimensional space. In this there are defined regions of expected and not expected malignancy and if the values are located within either region the corresponding conclusion can be obtained in regard of the fact if the person has or has not cancer. If the values are located outside these regions a safe conclusion cannot be obtained. Further, as a criterion can be used the difference and/or the quotient of the values determined for some characteristic property of these resonances. As a characteristic property the peak value, the width at half height of the area can be chosen. Instead of the width at half height the value can be used which is obtained by first determining the total area of a resonance over a particular level and by dividing this area by the height of the resonance line over the underlying resonances.

Abstract translation: 提出了一种通过使用血浆的NMR光谱来检测人类癌症，特别是恶性肿瘤的方法。 在记录的频谱中，确定共振，并且对于这些值，计算数学上可定义的性质，例如在最简单的情况下，谐振的高度和在一半高度处的共振的宽度的值。 有利地，使用至少两个不同的可数学定义的属性，并将相应的值视为输入到多维空间中。 在这种情况下，存在预期和未预期的恶性肿瘤的确定区域，如果这些值位于任一区域内，则可以获得关于如果该人具有或没有癌症的事实的相应结论。 如果值位于这些区域之外，则无法获得安全的结论。 此外，作为标准，可以使用为这些谐振的一些特性所确定的值的差值和/或商。 作为特征属性，可以选择峰值，该区域的半高处的宽度。 代替半高的宽度，可以使用通过首先确定在特定水平上的共振的总面积并且通过将该面积除以基础谐振之上的谐振线的高度而获得的值。

公开(公告)号：WO1991011958A1

公开(公告)日：1991-08-22

申请号：PCT/US1991001004

申请日：1991-02-13

Applicant: BRIGHAM AND WOMEN'S HOSPITAL

Inventor： BRIGHAM AND WOMEN'S HOSPITAL ,  JOLESZ, Ferenc, A. ,  JAKAB, Peter, D.

IPC: A61B05/055

CPC classification number: G10K15/043 ,  A61B17/22004 ,  A61B17/2256 ,  A61B2090/374 ,  B06B1/04 ,  G01R33/28

Abstract: A magnetic resonance imaging device (502, 504, 506, 508, 606, 608) is used to provide the static magnetic field (Bo) for transducers (120, 520, 620). The static magnetic field in combination with electric current pulses (118) energize phased arrayed transducers to generate acoustic waves or motion. The transducers (120, 520, 620) can be arranged in the magnetic resonance imaging device static magnetic field (Bo) to focus acoustic shock waves for the disintegration of target calculi in extracorporeal shock wave lithotripsy. The magnetic resonance imaging device is also used for target localization and monitoring of the mechanical energy effects of the transducers. In further embodiments, the transducers include coils that are implantable within a subject body and can be moved in the magnetic resonance imaging device's static magnetic field.

公开(公告)号：WO1991007132A1

公开(公告)日：1991-05-30

申请号：PCT/US1990006781

申请日：1990-11-21

Applicant: THE UNITED STATES OF AMERICA, represented by THE ...

Inventor： THE UNITED STATES OF AMERICA, represented by THE ... ,  DELANNOY, José ,  CHEN, Ching-nien ,  LEBIHAN, Denis ,  LEVIN, Ronald ,  TURNER, Robert

IPC: A61B05/055

CPC classification number: A61N1/403 ,  A61B5/055 ,  G01R33/28 ,  G01R33/3628 ,  G01R33/4804

Abstract: An apparatus for hyperthermia treatment of cancer comprising a combined hyperthermia applicator/MRI probe (1, 6) comprises an MRI probe that includes a tuning/matching circuit and a coil (1) for receiving and transmitting magnetic resonance signals, the tuning/matching circuit and radio frequency coil (1) being operably connected to one another and the MRI probe (1, 6) to be positioned inside a magnet to provide information which permits the control of the amount of radiant energy transmitted by the hyperthermia applicator to control and/or maintain the temperature at the subject's body part being treated within about +/-0.5 DEG C.

Abstract translation: 包括组合的热疗施加器/ MRI探针（1,6）的癌症的热疗治疗装置包括MRI探针，其包括调谐/匹配电路和用于接收和传输磁共振信号的线圈（1），所述调谐/匹配电路 和射频线圈（1）彼此可操作地连接并且所述MRI探针（1,6）定位在磁体内部以提供信息，所述信息允许控制由所述热疗器施加器传递的辐射能量的量来控制和/ 或将受试者身体部位的温度保持在约+/- 0.5℃内进行治疗。

公开(公告)号：WO1990006081A1

公开(公告)日：1990-06-14

申请号：PCT/US1989005429

申请日：1989-12-05

Applicant: OLYMPUS CORPORATION

Inventor： OLYMPUS CORPORATION ,  COSTELLO, James, G.

IPC: A61B05/055

CPC classification number: A61B5/055 ,  G01R33/28 ,  G02B6/06 ,  G09F9/305

Abstract: A coherent fiberoptic display (9) for a region having strong magnetic field comprises transfer optics (2) which launch the image into one end of a coherent fiberoptic bundle (3) that transfers the image from (1) to a fiberoptic display (9). The image from (1) is viewed on the expanded end of a fiberoptic taper (8). The image can comprise a video image formed by a CRT (1) located in a region of low magnetic flux density (5) and the fiberoptic taper (8) can be positioned in the imaging zone of a Magnetic Resonance Imaging (MRI) apparatus (10). The video image can allow the patient (11) to watch television during magnetic resonance imaging. This distraction will reduce the anxiety experienced during magnetic resonance so that the patient is less apt to move and the magnetic resonance images are less apt to be blurred or destroyed. The efficiency of magnetic resonance imaging is thus improved.

公开(公告)号：WO1998046131A1

公开(公告)日：1998-10-22

申请号：PCT/US1998007132

申请日：1998-04-10

Applicant: NORTHWESTERN UNIVERSITY ,  JUDD, Robert, M. ,  PARRISH, Todd, B.

Inventor： NORTHWESTERN UNIVERSITY

IPC: A61B05/055

CPC classification number: A61B5/055 ,  A61B5/7285

Abstract: Methods for increasing the efficiency of Na and K imaging of biological tissue are provided. For maximum efficiency, the receiver bandwidth is set equal to or less than the quantity Nro/T 2. Methods for assessing cardiac tissue viability using Na imaging are also provided.

Abstract translation: 提供了提高生物组织的23 Na和39 K成像效率的方法。 为了最大效率，将接收机带宽设置为等于或小于Nro / T * 2的数量。 还提供了使用Na成像来评估心脏组织活力的方法。

公开(公告)号：WO1996003073A1

公开(公告)日：1996-02-08

申请号：PCT/US1994008436

申请日：1994-07-26

Applicant: LASKER, Sigmund, E.

IPC: A61B05/055

CPC classification number: G01R33/5601 ,  A61K49/18 ,  G01R33/465

Abstract: The present invention provides a process for visualizing tissue metabolism in a subject comprising injecting O2 into the peritoneal cavity of a subject and detecting formed H2 O in tissues of the subject. The O2 is injected as a gas or as microbubbles formed from an aqueous protein solution.

Abstract translation: 本发明提供了一种用于可视化受试者中的组织代谢的方法，包括将17 O 2注射到受试者的腹膜腔内并检测受试者组织中形成的H2α7。 作为气体注入<17> O 2，或作为由蛋白质水溶液形成的微泡注入。

公开(公告)号：WO1996000520A1

公开(公告)日：1996-01-11

申请号：PCT/IB1995000484

申请日：1995-06-15

Applicant: PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB

Inventor： PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB ,  MEULENBRUGGE, Hendrik, Jan ,  TUITHOF, Hans, Hermanus ,  VAN VAALS, Johannes, Jacobus

IPC: A61B05/055

CPC classification number: G01R33/4812

Abstract: The invention relates to a magnetic resonance device (1) for imaging inter alia human organs by way of magnetic resonance. When interventional techniques are applied in combination with a magnetic resonance device (1), the organs are suitably visualized, but the instruments guided to an organ via an opening in the body are not visible or only hardly so. These instruments must be imaged by means of an X-ray device (20); the patient must then be transported some distance, for example a few meters, in order to obtain distortion-free images of the instruments. Transporting the patient has some drawbacks. There is a risk of motion of the instruments within the patient and, moreover, the coordinate systems of the MR device (1) and the X-ray device (20) might deviate from one another. A solution consists in arranging the X-ray device (20) immediately adjacent to or in the MR device (1), so that the patient need not be transported at all or only over a small distance. The undesired mutual influencing of the MR device (1) and the X-ray device (20) is counteracted, for example by using a solid-state X-ray detector (22) which includes a solid-state image pick-up device and, for example by making the position of the X-ray tube (40) dependent on the static magnetic field of the magnetic resonance device.

Abstract translation: 本发明涉及一种用于通过磁共振对人体器官进行成像的磁共振装置（1）。 当介入技术与磁共振装置（1）组合使用时，器官被适当地可视化，但是通过身体中的开口引导到器官的器械是不可见的，或者几乎不可见。 这些仪器必须通过X射线装置（20）成像; 然后必须将患者运送一些距离，例如几米，以获得乐器的无变形图像。 运送病人有一些缺点。 在患者体内存在仪器运动的风险，此外，MR装置（1）和X射线装置（20）的坐标系可能彼此偏离。 解决方案在于将X射线装置（20）直接设置在MR装置（1）附近，或者放置在MR装置（1）中，使得患者不需要全部输送，也可以仅在一小段距离内进行运送。 MR装置（1）和X射线装置（20）的不期望的相互影响被抵消，例如通过使用固态X射线检测器（22），其包括固态图像拾取装置和 ，例如通过使X射线管（40）的位置取决于磁共振装置的静磁场。

公开(公告)号：WO1995020909A1

公开(公告)日：1995-08-10

申请号：PCT/US1995001354

申请日：1995-01-31

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY

Inventor： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY ,  KERR, Adam, B. ,  PAULY, John, M.

IPC: A61B05/055

CPC classification number: G01R33/446 ,  G01R33/586

Abstract: Selective RF pulses are applied for segmented k-space imaging sequences with the tip-angle profiles of the pulses varying for stabilizing the entire signal profile and reducing ghosting and blurring artifacts in slice images.

Abstract translation: 选择性RF脉冲被应用于分段的k空间成像序列，其中脉冲的尖角分布变化以稳定整个信号分布并减少切片图像中的重影和模糊伪像。

公开(公告)号：WO1995014428A1

公开(公告)日：1995-06-01

申请号：PCT/US1994013749

申请日：1994-11-23

Applicant: MAGNA-LAB INC. ,  MARANDOS, Thomas, A.

Inventor： MAGNA-LAB INC.

IPC: A61B05/055

CPC classification number: G01R33/34084 ,  A61B5/0555 ,  A61B2017/00557 ,  G01R33/285

Abstract: An inflatable coil positioning device (10) includes a coil (38), a first inflatable sleeve (12) disposed radially about the coil (38) and a second inflatable sleeve (14) disposed radially within the coil (38). The first inflatable sleeve (12) and the second inflatable sleeve (14) each include at least two sections. The coil (38) is placed about a target section (22) of the patient to be imaged. The second inflatable sleeve (14) is inflated until the coil (38) is securely mounted on the target section (22). The mounted coil (38) and target section of the patient are then placed within a predetermined section of a nuclear magnetic resonance imaging magnet (24). The first inflatable sleeve (12) is inflated until the mounted coil (38) and target section (22) of the patient are securely retained within the predetermined section of the magnet (24).

Abstract translation: 可充气线圈定位装置（10）包括线圈（38），围绕线圈（38）径向设置的第一可充气套筒（12）和径向设置在线圈（38）内的第二可膨胀套筒（14）。 第一可充气套筒（12）和第二可充气套筒（14）各自包括至少两个部分。 围绕要成像的患者的目标部分（22）放置线圈（38）。 第二可充气套筒（14）被充气，直到线圈（38）牢固地安装在目标部分（22）上。 然后将安装的线圈（38）和患者的目标部分放置在核磁共振成像磁体（24）的预定部分内。 第一可膨胀套筒（12）被充气，直到患者的安装线圈（38）和目标部分（22）牢固地保持在磁体（24）的预定部分内。

公开(公告)号：WO1995004499A1

公开(公告)日：1995-02-16

申请号：PCT/US1994008988

申请日：1994-08-04

Applicant: SPECTRAL PHARMACEUTICALS, INC.

Inventor： SPECTRAL PHARMACEUTICALS, INC. ,  BLOCK, Ronald, E.

IPC: A61B05/055

CPC classification number: G01R33/5601 ,  A61K49/10 ,  A61K49/12 ,  Y10T436/24

Abstract: This invention is directed to a magnetic resonance imaging composition for imaging of an organ or organ system comprising an organic silicon compound. Preferably, the organ system is the gastrointestinal tract. The present invention is further directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of an organic silicon compound suspended or dispersed in a physiologically tolerable carrier and generating a magnetic resonance image of said mammal. In a preferred embodiment, the organic silicon compound is a silane. In another preferred embodiment, the organic silicon compound is a siloxane. In yet another preferred embodiment, the organic silicon compoud is a polysiloxane.

Abstract translation: 本发明涉及用于对包含有机硅化合物的器官或器官系统进行成像的磁共振成像组合物。 优选地，器官系统是胃肠道。 本发明进一步涉及一种诊断方法，其包括给予哺乳动物有效量的有机硅化合物，其悬浮或分散在生理上可耐受的载体中并产生所述哺乳动物的磁共振图像。 在优选的实施方案中，有机硅化合物是硅烷。 在另一个优选的实施方案中，有机硅化合物是硅氧烷。 在另一个优选的实施方案中，有机硅组合物是聚硅氧烷。