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公开(公告)号：NO20015237L
公开(公告)日：2001-12-21
申请号：NO20015237
申请日：2001-10-26
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HORNBERGER WILFRIED
IPC: C12N9/99 , A61K31/27 , A61K31/381 , A61K31/421 , A61K31/426 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/10 , A61P3/14 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07C275/42 , C07D207/34 , C07D213/56 , C07D249/14 , C07D263/34 , C07D263/48 , C07D277/20 , C07D277/48 , C07D277/56 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/02 , C07K5/023 , A61K38/06
Abstract: The invention relates to new compounds which bind to integrin receptors, as well as to their production, their use as integrin receptor antagonists and for the treatment of diseases, pharmaceutical preparations containing said compounds and pharmaceutical preparations containing at least one other active compound.
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公开(公告)号：NO20014807L
公开(公告)日：2001-12-04
申请号：NO20014807
申请日：2001-10-03
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , A61K31/4427
Abstract: The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
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公开(公告)号：NO20014807A
公开(公告)日：2001-12-04
申请号：NO20014807
申请日：2001-10-03
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , A61K31/4427
CPC classification number: C07K5/06078 , A61K38/00 , C07B43/00 , C07D401/12
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公开(公告)号：NO20014875L
公开(公告)日：2001-11-13
申请号：NO20014875
申请日：2001-10-08
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , A61K38/05
Abstract: The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.
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公开(公告)号：NO20014961A
公开(公告)日：2001-11-07
申请号：NO20014961
申请日：2001-10-12
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: C07D239/36 , A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D233/54
CPC classification number: C07D405/14 , A61K45/06 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/12 , C07D417/14
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Patent Agency Ranking
公开(公告)号：DE19948269A1
公开(公告)日：2001-04-12
申请号：DE19948269
申请日：1999-10-06
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , SUBKOWSKI THOMAS , KLING ANDREAS , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , GENESTE HERVE , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K45/06 , C07D263/34 , C07D277/48 , C07D307/68 , C07D333/38 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/02 , C07K5/08 , A61K38/06 , A61K45/00 , C07C233/00 , C07K5/097
Abstract: Compounds (I) and their salts, prodrugs, enantiomers and tautomers are new. Compounds of formula A-E-G-L (I) and their salts, prodrugs, enantiomers and tautomers are new. L = N(R )-CH(R )-(CHR )a-T; T = COOH or a group that hydrolyzes to form COOH; R = e.g. H or NHSO2R ; R = H or -(CH2)b-(X)c-R ; a, c = 0 or 1; b = 0-3; X = e.g. -SO2-, -S-, -O-, -CO- or -O-CO-; R , R = e.g. optionally substituted 1-6C alkyl; R = e.g. H or optionally substituted 1-4C alkyl; G = N(R )-(CH(CH2)dR )-CO; R = e.g. H, OH or optionally substituted 1-4C alkyl; R = e.g. H or optionally substituted 1-4C alkyl; d = 0-2; E = (NH)g-(CH2)f-Q-(CH2)e-CO; f, g = 0 or 1; e = 0-2; Q = optionally substituted heteroaryl; A = e.g. uracil-5-yl, 2-(1-pyrrolinyl), 2-(3,4,5,6-tetrahydropyridinyl) or 2-(4,5-dihydroimidazol-5-one). The full definition is given in the DEFINITION (Full Definition) Field.
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公开(公告)号：AU4551500A
公开(公告)日：2000-11-17
申请号：AU4551500
申请日：2000-04-17
Applicant: BASF AG
Inventor： KLING ANDREAS , LANGE UDO , LAUTERBACH ARNULF , GENESTE HERVE , SUBKOWSKI THOMAS , ZECHEL JOHANN-CHRISTIAN , GRAEF CLAUDIA ISABELLA , HORNBERGER WILFRIED
IPC: C12N9/99 , A61K31/27 , A61K31/381 , A61K31/421 , A61K31/426 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K38/00 , A61K45/00 , A61K45/06 , A61P3/10 , A61P3/14 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P43/00 , C07C275/42 , C07D207/34 , C07D213/56 , C07D249/14 , C07D263/34 , C07D263/48 , C07D277/20 , C07D277/48 , C07D277/56 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/02 , C07K5/023 , A61K38/04 , A61K31/33
Abstract: The invention relates to new compounds which bind to integrin receptors, as well as to their production, their use as integrin receptor antagonists and for the treatment of diseases, pharmaceutical preparations containing said compounds and pharmaceutical preparations containing at least one other active compound.
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公开(公告)号：AU4112900A
公开(公告)日：2000-11-14
申请号：AU4112900
申请日：2000-03-29
Applicant: BASF AG
Inventor： ZECHEL JOHANN-CHRISTIAN , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , SADOWSKI JENS , HORNBERGER WILFRIED
IPC: C07D239/36 , A61K31/505 , A61K45/00 , A61K45/06 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , C07D239/34 , C07D239/60 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.
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公开(公告)号：CA2370267A1
公开(公告)日：2000-10-19
申请号：CA2370267
申请日：2000-04-05
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , DELZER JURGEN , BACKFISCH GISELA , SEITZ WERNER , HORNBERGER WILFRIED
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , A61K38/05
Abstract: The invention relates to prodrugs of pharmacologically active, five-membered heterocyclic amidines from which in vivo compounds are obtained, these compounds being competitive inhibitors of trypsin-type serin proteases, especially thrombin and kininogenases such as kallikrein. The invention also relates to the production of these prodrugs and to their use as medicaments, to pharmaceutical compositions that contain the prodrugs of the active compounds as components, and to the use of the compounds as thrombin inhibitors, anticoagulants and anti-inflammatory agents.
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公开(公告)号：BR9810574A
公开(公告)日：2000-09-19
申请号：BR9810574
申请日：1998-06-23
Applicant: BASF AG
Inventor： SUBKOWSKI THOMAS , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K39/395 , A61P7/02 , A61P7/04 , A61P39/02 , C07K16/00 , C07K16/40 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/573
Abstract: Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof are used in pharmaceutical preparations and in diagnosis. Cells which express these antibodies, antibody fragments, mixtures or derivatives thereof are also disclosed.
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