公开(公告)号：US11697833B2

公开(公告)日：2023-07-11

申请号：US16464681

申请日：2017-11-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Omai Garner ,  Dino Di Carlo ,  Steve Wei Feng

IPC: G01N21/25 ,  C12M1/32 ,  C12M1/34 ,  C12Q1/18 ,  G06V10/12 ,  G06V20/69 ,  G01N21/64

CPC classification number: C12Q1/18 ,  G01N21/253 ,  G06V10/12 ,  G06V20/69 ,  G01N2201/0221 ,  G01N2201/0833

Abstract: A method of performing antimicrobial susceptibility testing (AST) on a sample uses a reader device that mounts on a mobile phone having a camera. A microtiter plate containing wells preloaded with the bacteria-containing sample, growth medium, and drugs of differing concentrations is loaded into the reader device. The wells are illuminated using an array of illumination sources contained in the reader device. Images of the wells are acquired with the camera of the mobile phone. In one embodiment, the images are transmitted to a separate computing device for processing to classify each well as turbid or not turbid and generating MIC values and a susceptibility characterization for each drug in the panel based on the turbidity classification of the array of wells. The MIC values and the susceptibility characterizations for each drug are transmitted or returned to the mobile phone for display thereon.

公开(公告)号：US11668653B2

公开(公告)日：2023-06-06

申请号：US15776649

申请日：2016-11-16

Applicant: ChemImage Corporation

Inventor： Patrick Treado ,  Shona Stewart ,  Aaron Smith ,  Heather Gomer

IPC: G01N21/65 ,  G01J3/44 ,  G01N21/17 ,  G01J3/02 ,  G01J3/28 ,  G16H50/20 ,  G01N33/53

CPC classification number: G01N21/65 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/17 ,  G01N33/53 ,  G16H50/20 ,  G01N2201/0833 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60

Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

公开(公告)号：US20180313758A1

公开(公告)日：2018-11-01

申请号：US15583899

申请日：2017-05-01

Applicant: Wyatt Technology Corporation

Inventor： Vincent Hsieh ,  Mario Yasa, Jr. ,  Steven C Minne

IPC: G01N21/64 ,  G01N21/51

CPC classification number: G01N21/6452 ,  G01N21/474 ,  G01N21/51 ,  G01N2021/4747 ,  G01N2021/475 ,  G01N2021/6484 ,  G01N2201/0833

Abstract: An apparatus for the high throughput measurement of optical properties of liquid samples placed into the wells of a multiwell plate is disclosed. An optical fiber within a fiber bundle containing no corrective optics between the fiber ends and the well plate bottom illuminates the sample in order to induce fluorescence, and multiple fibers collect emission radiation and transmit it to a fluorescence detector such as a spectrometer. Other embodiments involve a light scattering illumination source with detection fibers located in either the same bundle containing the fluorescence monitoring fibers or an independent light scattering detection bundle for the measurement of static and/or dynamic light scattering. Some embodiments of the invention permit the measurement of phase analysis light scattering. Thus the measurement of multiple optical properties of a liquid sample may be made simultaneously or in succession. A method for these measurements is also disclosed.

公开(公告)号：US10082425B2

公开(公告)日：2018-09-25

申请号：US15282305

申请日：2016-09-30

Applicant: UNITY SEMICONDUCTOR

Inventor： Philippe Gastaldo

IPC: G01J3/02 ,  G01J3/453 ,  G01J3/18

CPC classification number: G01J3/0208 ,  G01B11/022 ,  G01B11/0608 ,  G01B11/22 ,  G01B11/245 ,  G01B2210/50 ,  G01B2210/56 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/453 ,  G01N21/8806 ,  G01N21/8851 ,  G01N21/9501 ,  G01N21/956 ,  G01N2201/063 ,  G01N2201/0833 ,  G01N2201/105 ,  G02B21/0064 ,  H01L22/12

Abstract: A confocal chromatic device is provided, including at least one chromatic lens with an extended axial chromatism; at least one broadband light source; at least one optical detector; and at least one measurement channel with a planar Y-junction made with a planar waveguide optics technology, and arranged for transferring light from the at least one light source towards the at least one chromatic lens and for transferring light reflected back through the at least one chromatic lens towards the at least one optical detector.

公开(公告)号：US20180266962A1

公开(公告)日：2018-09-20

申请号：US15982373

申请日：2018-05-17

Applicant: SciAps, Inc.

Inventor： David R. Day

IPC: G01N21/71 ,  G01J3/443

CPC classification number: G01N21/718 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/443 ,  G01N2201/0221 ,  G01N2201/0833

Abstract: A spectrometer system and method including a laser source for directing a laser beam to a sample producing plasma radiation on the sample. At least one fiber of a fiber bundle is connected to an illumination source for directing light to the sample. A spectrometer subsystem receives plasma radiation from the sample via the detection fiber bundle and receives light from the illumination source reflected off the sample also via the detection fiber bundle for detecting the presence of the sample.

公开(公告)号：US10024799B2

公开(公告)日：2018-07-17

申请号：US15122170

申请日：2015-02-13

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Siva Umapathy ,  Sanchita Sil ,  Gagan Dhal ,  Freek Ariese

IPC: G01J3/44 ,  G01N21/65 ,  G01B11/00 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01B11/00 ,  G01J3/0221 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/4795 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: The invention provides a method for chemical signature resolved detection of a concealed object within a system. The method includes irradiating the system at a plurality of positions with aplurality of electromagnetic radiation of specific wavelength; capturing a certain component of the scattered electromagnetic radiation from the object at a plurality of locations along various 3D planes around the system; obtaining a plurality of profiles from the captured component of the scattered electromagnetic radiation; filtering the profiles to obtain a chemical signature specific to the object; and resolving the chemical signatures to detect the concealed object, wherein, the step of detection includes determination of the shape, size and location of the object.

公开(公告)号：US20180100800A1

公开(公告)日：2018-04-12

申请号：US15805123

申请日：2017-11-06

Applicant: KUANTAG NANOTEKNOLOJILER GELISTIRME VE URETIM A.S. ,  KOC UNIVERSITESI

Inventor： HAKAN UREY ,  OSMAN VEDAT AKGUN ,  EMRE HEVES ,  FEHMI CIVITCI ,  BASARBATU CAN

IPC: G01N21/64 ,  G01N21/85

CPC classification number: G01N21/643 ,  G01N21/645 ,  G01N21/8507 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0624 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: In the present invention, a fluorescent substance detection system (S) for detecting fluorescent substances in any environment is provided. Said detection system (S) comprises at least one illumination unit (1) which emits light to said environment in order to excite said substances; detection units (2), at least at a number equal to the number of types of fluorescent substances, for detecting emissions coming from said excited fluorescent substances and bandpass filters (3), each connected to detection units (2) one by one, wherein bandpass filters (3) have a center wavelength matched to the center emission wavelength of corresponding fluorescent substance.

公开(公告)号：US09939383B2

公开(公告)日：2018-04-10

申请号：US15016489

申请日：2016-02-05

Applicant: SciAps, Inc.

Inventor： David R. Day

IPC: G01J3/30 ,  G01N21/71 ,  G01J3/443

CPC classification number: G01N21/718 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/443 ,  G01N2201/0221 ,  G01N2201/0833

Abstract: An analysis (e.g., LIBS) system includes a source of radiation, an optical emission path for the radiation from the source of radiation to a sample, and an optical detection path for photons emitted by the sample. A detector fiber bundle transmits photons to the spectrometer subsystem. At least one fiber of the fiber bundle is connected to an illumination source (e.g., an LED) for directing light via at least a portion of the detection path in a reverse direction to the sample for aligning, sample presence detection, localizing, and/or focusing based on analysis of the resulting illumination spot on the sample.

公开(公告)号：US09921149B2

公开(公告)日：2018-03-20

申请号：US15027536

申请日：2015-04-24

Applicant: Otsuka Electronics Co., Ltd.

Inventor： Tsutomu Mizuguchi

IPC: G01N33/00 ,  G01N21/27 ,  G01N21/25

CPC classification number: G01N21/27 ,  G01N21/255 ,  G01N21/8422 ,  G01N33/00 ,  G01N2021/8411 ,  G01N2033/0096 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A controller of an optical measurement apparatus causes, in a condition that a rotational speed of a rotary body is controlled so that the speed is a specified value, a light source to generate light having a constant intensity and apply the light to an irradiation region, and acquires first timing information based on a change with time of an intensity of reflected light or transmitted light that is output from a second detection unit receiving the reflected light or transmitted light of the applied light. The controller causes the light source to periodically generate pulsed light in accordance with the first timing information and apply the pulsed light to the irradiation region, and acquires second timing information based on a result which is output from the first detection unit whose measurement is periodically enabled in accordance with the first timing information.

公开(公告)号：US09833147B2

公开(公告)日：2017-12-05

申请号：US14361428

申请日：2012-11-09

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Toshihiko Suzuki ,  Yutaka Yamashita ,  Yukio Ueda ,  Etsuko Yamaki ,  Daisuke Yamashita ,  Kenji Yoshimoto ,  Harumi Sakahara ,  Hiroyuki Ogura ,  Hatsuko Nasu

IPC: A61B5/00 ,  A61B8/08 ,  A61B8/00 ,  G01N21/47

CPC classification number: A61B5/0091 ,  A61B5/0035 ,  A61B5/708 ,  A61B8/0825 ,  A61B8/4416 ,  A61B2562/046 ,  A61B2562/146 ,  A61B2562/168 ,  G01N21/4795 ,  G01N2021/4797 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A mammography device is disclosed. The mammography device includes a container configured to surround the breast and a plurality of optical fibers attached to be directed inward in the container and configured to perform radiation and detection of light. The container has a base member having an opening, a plurality of annular members continuously disposed to come in communication with the opening, and a bottom member disposed inside the annular member spaced the farthest distance from the base member. The annular members and the bottom member are configured to relatively displace the adjacent annular member on the side of the base member or the base member in a communication direction. Some of the plurality of optical fibers is attached to the plurality of annular members.