公开(公告)号：BR112012016305A2

公开(公告)日：2017-05-02

申请号：BR112012016305

申请日：2010-12-31

Applicant: STC UNM

Inventor： BRYCE CHACKERIAN ,  DAVID S PEABODY

IPC: C07K14/005 ,  A61K39/12 ,  C12N7/01 ,  C12N15/33

Abstract: patente de invenção: "plasmídeos e métodos para exibição de peptídeo e seleção de afinidade em partículas semelhantes a vírus de bacteriófagos de rna". a presente invenção refere-se a um sistema e a métodos para controlar a valência de exibição de pepídeos em particulas semelhantes a vírus (vlps), especialmente incluindo vlps ms2. neste método, grandes quantidades de proteínas revestidas do tipo selvagem e baixas quantidades de proteínas revestidas de dímero de cadeia única podem ser produzidas de um único rna. a valência é controlada na produção de imunògeno (vacina), proporcionando um sistema que permite a produção de grandes quantidades de proteínas revestidas do tipo selvagem e baixas quantidades de proteínas revestidas de dímero de cadeia única podem ser produzidas de um único rna, permitindo o ajuste fácil de niveis de valência de exibição em vlps, especialmente vlps ms2 por uma ampla gama de um, em média, até tantoquanto 90 por partícula. isto facilita a produção de imunógenos e vacinas, incluindo vlps exibindo valência baixa. as construções de ácido nucleico úteis na expressão de partículas semelhantes a vírus são apresentadas, compreendendo um polipeptídeo revestido de ms2 modoficado pela inserção de um peptídeo heterólogo, em que o peptídeo heterólogo é exibido sobre a partícula semelante a vírus e encapsula o ms2 de nirna. as construções de ácido nucleico são tmbém apresentadas, as quais são úteis na expressão de partículas semelhantes a vírus compreendendo um polipepeptídeo revestido de pp7 modificado pela inserção de um peptídeo heterólogo, em que o peptídeo heterólogo é exibido sobre a particula semelhante a vírus e encapsula o pp7 de mrna.

公开(公告)号：HK1219074A1

公开(公告)日：2017-03-24

申请号：HK16107096

申请日：2016-06-21

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B

IPC: B01J20060101 ,  H01M20060101

公开(公告)号：CA2979531A1

公开(公告)日：2016-09-22

申请号：CA2979531

申请日：2016-03-14

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B

IPC: H01M8/1004 ,  H01M4/86 ,  H01M4/92

Abstract: Methods for optimizing, designing, making, and assembling various component parts and layers to produce optimized MEAs. Optimization is generally achieved by producing multi-layered MEAs wherein characteristics such as catalyst composition and morphology, ionomer concentration, and hydrophobicity/hydophilicity are specifically tuned in each layer. The MEAs are optimized for use with a variety of catalysts including catalysts with specifically designed and controlled morphology, chemical speciation on the bulk, chemical speciation on the surface, and/or specific hydrophobic or hydrophilic or other characteristics. The catalyst can incorporate non-platinum group metal (non-PGM) and/or platinum group metal (PGM) materials.

公开(公告)号：AU2014312200A8

公开(公告)日：2016-05-05

申请号：AU2014312200

申请日：2014-08-28

Applicant: STC UNM

Inventor： PLUSQUELLIC JAMES

IPC: G06F11/30 ,  H05B44/00 ,  G06F11/16

Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.

公开(公告)号：CA2961372A1

公开(公告)日：2016-03-24

申请号：CA2961372

申请日：2015-09-16

Applicant: CARBO CERAMICS INC ,  SANDIA CORP ,  STC UNM

Inventor： CANNAN CHAD ,  PALISCH TERRENCE ,  KEMP RICHARD A ,  BOYLE TIMOTHY J ,  HERNANDEZ-SANCHEZ BERNADETTE A ,  MILLER JAMES E

IPC: C09K8/80 ,  E21B43/267 ,  E21B47/11

Abstract: Proppant compositions for use in hydraulic fracturing and methods of using same are disclosed herein. The proppant compositions include a plurality of proppant particulates and at least one particulate of the plurality of proppant particulates containing at least one tracer, wherein the at least one tracer separates from the at least one particulate located inside a fracture of a subterranean formation after a period of time.

公开(公告)号：IL240441D0

公开(公告)日：2015-09-24

申请号：IL24044115

申请日：2015-08-09

Applicant: STC UNM

IPC: B01J20060101

Abstract: Novel active supports, novel catalysts, and methods of preparing active supports using a sacrificial template particles and methods of preparing the same are all described.

公开(公告)号：AU2013331477A1

公开(公告)日：2015-04-16

申请号：AU2013331477

申请日：2013-10-15

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B ,  HALEVI BARR ,  SHORT PAUL

IPC: B01J37/08 ,  B01J23/745

Abstract: Novel catalytic materials and novel methods of preparing M-N-C catalytic materials utilizing a sacrificial support approach and using inexpensive active polymers as the carbon and nitrogen source and readily available metal precursors are described.

公开(公告)号：AU2012284147A1

公开(公告)日：2014-02-27

申请号：AU2012284147

申请日：2012-07-18

Applicant: STC UNM

Inventor： ZEINELDEN REEMA

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/22 ,  A61K47/30 ,  A61K47/48 ,  A61P35/00

Abstract: In one embodiment, the invention provides a new design of nanocarrier compositions that release their therapeutic load specifically at intraperitoneal cancers' site. These nanocarriers are administered intraperitoneally and comprise a plurality of porous nanoparticulates that (a) are loaded with one or more pharmaceutically-active agents alone or in combination with imaging agents thus providing a theranostic value and (b) that are encapsulated by and that support a lipid bilayer which is disrupted upon contact with a reactive oxygen species generated within the environment of the cancer. In other embodiments, the invention provides methods of treatment and pharmaceutical compositions comprising nanocarriers as described herein.

公开(公告)号：AU2012249474A1

公开(公告)日：2013-11-07

申请号：AU2012249474

申请日：2012-04-27

Applicant: STC UNM ,  SANDIA CORP

Inventor： BRINKER JEFFREY C ,  CARNES ERIC C ,  ASHLEY CARLEE ERIN

IPC: A61K9/16 ,  A61K38/17 ,  A61K47/30 ,  A61K47/48 ,  A61K48/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：NZ570678A

公开(公告)日：2010-10-29

申请号：NZ57067807

申请日：2007-03-09

Applicant: STC UNM

Inventor： HERSEE STEPHEN M ,  WANG XIN ,  SUN XINYU

IPC: H01L21/20

Abstract: A method of making nanowires comprising: forming a selective growth mask over a substrate, wherein the selective growth mask comprises a plurality of patterned apertures that expose a plurality of portions of the substrate; using a selective non-pulsed growth mode to grow a semiconductor material on each of the plurality of portions of the substrate exposed in each of the patterned apertures; performing a growth-mode transition from the non-pulsed growth mode to a pulsed growth mode; and forming a plurality of semiconductor nanowires by continuing the pulsed growth mode of the semiconductor material. Also disclosed is a group III-N nanowire array comprising: a substrate; a selective growth mask over the substrate, wherein the selective growth mask comprises a plurality of patterned apertures that expose a plurality of portions of the substrate; and a group III-N nanowire connected to and extending from each of the plurality of portions of the substrate, wherein the group III-N nanowire Is oriented along a single direction and maintains a cross-sectional feature of one of the plurality of selected surface regions, and wherein the group Ill-N nanowire extends over a top of the selective growth mask.