公开(公告)号：US20090273840A1

公开(公告)日：2009-11-05

申请号：US12432829

申请日：2009-04-30

Applicant: Sheldon MCLAUGHLIN

Inventor： Sheldon MCLAUGHLIN

IPC: G02B5/18

CPC classification number: G02B6/29313 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0243 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/1804 ,  G01J3/22 ,  G02B5/12 ,  G02B5/1809 ,  G02B5/1814 ,  G02B5/1866 ,  G02B6/2931 ,  G02B6/29311 ,  G02B6/2938 ,  G02B6/354 ,  G02B17/0856 ,  G02B2005/1804

Abstract: A compact wavelength dispersing device and a wavelength selective optical switch based on the wavelength dispersing device is described. The wavelength dispersing device has a folding mirror that folds the optical path at least three times. A focal length of a focusing coupler of the device is reduced and the NA is increased, while the increased optical aberrations are mitigated by using an optional coma-compensating wedge. A double-pass arrangement for a transmission diffraction grating allows further focal length and overall size reduction due to increased angular dispersion.

Abstract translation: 描述了基于波长分散装置的紧凑型波长分散装置和波长选择光开关。 波长分散装置具有将光路折叠至少三次的折叠镜。 减少了设备的聚焦耦合器的焦距，并且增加了NA，同时通过使用可选的光阑补偿楔来减轻增加的光学像差。 用于透射衍射光栅的双通道布置允许由于增加的角度分散而使焦距和总体尺寸减小。

公开(公告)号：US20090270702A1

公开(公告)日：2009-10-29

申请号：US11722822

申请日：2006-01-20

Applicant: Haishan Zeng ,  Yasser Sherif Fawzy

Inventor： Haishan Zeng ,  Yasser Sherif Fawzy

IPC: A61B5/1455 ,  A61B6/00

CPC classification number: G01N21/474 ,  A61B1/043 ,  A61B1/2676 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0261 ,  A61B5/14542 ,  A61B5/1459 ,  G01J3/02 ,  G01J3/0243 ,  G01J3/0291 ,  G01N21/359 ,  G01N21/4795 ,  G01N2021/4742

Abstract: The present invention provides a new method and device for disease detection, more particularly cancer detection, from the analysis of diffuse reflectance spectra measured in vivo during endoscopic imaging. The measured diffuse reflectance spectra are analyzed using a specially developed light-transport model and numerical method to derive quantitative parameters related to tissue physiology and morphology. The method also corrects the effects of the specular reflection and the varying distance between endoscope tip and tissue surface on the clinical reflectance measurements. The model allows us to obtain the absorption coefficient (μa) and further to derive the tissue micro-vascular blood volume fraction and the tissue blood oxygen saturation parameters. It also allows us to obtain the scattering coefficients (μs and g) and further to derive the tissue micro-particles volume fraction and size distribution parameters.

Abstract translation: 本发明提供了一种用于疾病检测，特别是癌症检测的新方法和装置，其用于在内窥镜成像期间在体内测量的漫反射光谱。 使用特别开发的光传输模型和数值方法分析测量的漫反射光谱，以得出与组织生理学和形态相关的定量参数。 该方法还可以校正镜面反射和内窥镜尖端与组织表面之间距离变化对临床反射率测量的影响。 该模型允许我们获得吸收系数（mua），并进一步导出组织微血管血液体积分数和组织血氧饱和度参数。 它还允许我们获得散射系数（mus和g），并进一步导出组织微粒体积分数和尺寸分布参数。

公开(公告)号：US20090213362A1

公开(公告)日：2009-08-27

申请号：US12067751

申请日：2006-09-21

Applicant: Katsushige Nakamura ,  Minoru Nakamura ,  Katsuhiro Miura ,  Masao Doi

Inventor： Katsushige Nakamura ,  Minoru Nakamura ,  Katsuhiro Miura ,  Masao Doi

IPC: G01N21/00

CPC classification number: G01B11/24 ,  A61B5/0062 ,  A61B5/0075 ,  A61B5/444 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0243 ,  G01J3/36 ,  G01N21/25 ,  G01N21/31 ,  G01N2021/1734 ,  G01N2021/1736 ,  G02B7/32

Abstract: An optical measuring system has a first optical measuring instrument and a second optical measuring instrument. The optical measuring system includes a first optical path to guide a first beam from a measuring region to the first optical measuring instrument, a second optical path to guide a second beam from the measuring region to the second optical measuring instrument, an optical system through which the first and second optical paths extend and in which the first and second optical paths are paraxial, a reflection area to change the direction of the first optical path, the second optical path crossing the reflection area, and a light transmission area arranged at a position where the reflection area and second optical path cross each other, the light transmission area having a higher light transmittance than the reflection area.

Abstract translation: 光学测量系统具有第一光学测量仪器和第二光学测量仪器。 所述光学测量系统包括用于将第一光束从测量区域引导到所述第一光学测量仪器的第一光路，用于将第二光束从所述测量区域引导到所述第二光学测量仪器的第二光学路径， 第一和第二光路延伸并且其中第一和第二光路是近轴的，改变第一光路的方向的反射区域，与反射区域相交的第二光路以及布置在反射区域的光透射区域 其中反射区域和第二光路彼此交叉，透光区域具有比反射区域更高的透光率。

公开(公告)号：US20090153858A1

公开(公告)日：2009-06-18

申请号：US12379343

申请日：2009-02-19

Applicant: Noam Babayoff

Inventor： Noam Babayoff

IPC: G01J4/00 ,  G01B11/24 ,  G01J3/46

CPC classification number: H04N13/15 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/0615 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/24 ,  A61B1/247 ,  A61B5/0068 ,  A61B5/0088 ,  A61B5/1077 ,  A61B5/1079 ,  A61C9/0053 ,  A61C9/0066 ,  A61C19/04 ,  G01B11/24 ,  G01B11/25 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0243 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/462 ,  G01J3/50 ,  G01J3/501 ,  G01J3/508 ,  G01J3/51 ,  G01N21/255 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10028 ,  G06T2207/30036 ,  H01L27/14868 ,  H04N13/207 ,  H04N13/257 ,  H04N13/271 ,  H04N13/296

Abstract: A device for determining the surface topology and associated color of a structure, such as a teeth segment, includes a scanner for providing depth data for points along a two-dimensional array substantially orthogonal to the depth direction, and an image acquisition means for providing color data for each of the points of the array, while the spatial disposition of the device with respect to the structure is maintained substantially unchanged. A processor combines the color data and depth data for each point in the array, thereby providing a three-dimensional color virtual model of the surface of the structure. A corresponding method for determining the surface topology and associated color of a structure is also provided.

Abstract translation: 用于确定诸如齿段的结构的表面拓扑和相关联颜色的装置包括用于为基本上与深度方向正交的二维阵列的点提供深度数据的扫描器，以及用于提供颜色的图像获取装置 数据，而阵列相对于结构的空间布置基本上保持不变。 处理器组合阵列中每个点的颜色数据和深度数据，从而提供结构表面的三维颜色虚拟模型。 还提供了用于确定结构的表面拓扑和相关联颜色的相应方法。

公开(公告)号：US07190452B2

公开(公告)日：2007-03-13

申请号：US11058045

申请日：2005-02-14

Applicant: Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

Inventor： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

Abstract: Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

Abstract translation: 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US20060268271A1

公开(公告)日：2006-11-30

申请号：US11085450

申请日：2005-03-22

Applicant: Martin Liphardt ,  Ping He

Inventor： Martin Liphardt ,  Ping He

IPC: G01J4/00

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0243 ,  G01J4/00 ,  G01N21/211 ,  G02B17/008

Abstract: Low aberration relay systems modified to perform as spatial filters in reflectometer, spectrophotometer, ellipsometer, polarimeter and the like systems.

Abstract translation: 改进的低像差继电器系统作为反射计，分光光度计，椭偏仪，偏振计等系统中的空间滤波器。

公开(公告)号：US20060170919A1

公开(公告)日：2006-08-03

申请号：US11338276

申请日：2006-01-24

Applicant: Yoshifumi Takahashi ,  Takanori Saitoh ,  Kenichi Nakamura

Inventor： Yoshifumi Takahashi ,  Takanori Saitoh ,  Kenichi Nakamura

IPC: G01J3/28

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0243 ,  G01J3/1804 ,  G01J2003/2866

Abstract: An optical spectrum analyzer measures to-be-measured light while carrying out calibration processing for correcting wavelength information of spectrum data of the to-be-measured light by a wavelength information correction device through a storage device based on the spectrum data of reference light that is obtained by causing the reference light whose wavelength is known to be incident on a tunable wavelength filter from light incident devices at all times together with the to-be-measured light. Since the optical spectrum analyzer can continuously measure the to-be-measured light in a wide wavelength range at high speed while maintaining high wavelength accuracy, it can continuously obtain the spectrum data of the to-be-measured light with high wavelength accuracy even if it is installed in a place in which an environment intensely changes.

Abstract translation: 光谱分析仪在进行基于参考光的频谱数据的基于光的参考光的频谱数据的波长信息校正装置进行用于校正待测光的光谱数据的波长信息的校准处理时， 通过使波长已知的参考光与待测光一起入射到可调谐波长滤光器上，并从光入射装置始终进入。 由于光谱分析仪可以在保持高波长精度的同时高速连续地测量宽波长范围内的被测光，所以即使在高频波长精度的情况下也可以连续获得待测光的光谱数据 它安装在环境剧烈变化的地方。

公开(公告)号：US20060001739A1

公开(公告)日：2006-01-05

申请号：US11154520

申请日：2005-06-17

Applicant: Noam Babayoff

Inventor： Noam Babayoff

IPC: H04N13/02 ,  H04N15/00

CPC classification number: H04N13/15 ,  A61B1/00009 ,  A61B1/00096 ,  A61B1/0615 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/0676 ,  A61B1/0684 ,  A61B1/24 ,  A61B1/247 ,  A61B5/0068 ,  A61B5/0088 ,  A61B5/1077 ,  A61B5/1079 ,  A61C9/0053 ,  A61C9/0066 ,  A61C19/04 ,  G01B11/24 ,  G01B11/25 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/0243 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/462 ,  G01J3/50 ,  G01J3/501 ,  G01J3/508 ,  G01J3/51 ,  G01N21/255 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10028 ,  G06T2207/30036 ,  H01L27/14868 ,  H04N13/207 ,  H04N13/257 ,  H04N13/271 ,  H04N13/296

Abstract: A device for determining the surface topology and associated color of a structure, such as a teeth segment, includes a scanner for providing depth data for points along a two-dimensional array substantially orthogonal to the depth direction, and an image acquisition means for providing color data for each of the points of the array, while the spatial disposition of the device with respect to the structure is maintained substantially unchanged. A processor combines the color data and depth data for each point in the array, thereby providing a three-dimensional color virtual model of the surface of the structure. A corresponding method for determining the surface topology and associated color of a structure is also provided.

公开(公告)号：US20050203421A1

公开(公告)日：2005-09-15

申请号：US11053263

申请日：2005-02-07

Applicant: Haishan Zeng ,  Stephen Lam ,  Branko Palcic

Inventor： Haishan Zeng ,  Stephen Lam ,  Branko Palcic

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N23/00 ,  A61B6/00 ,  G21K1/12 ,  H05G1/60

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

Abstract: Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

Abstract translation: 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US06885445B2

公开(公告)日：2005-04-26

申请号：US10211558

申请日：2002-08-05

Applicant: Robert Bennett ,  Andrew Mark Woolfrey ,  John Charles Clifford Day ,  Angus Bewick

Inventor： Robert Bennett ,  Andrew Mark Woolfrey ,  John Charles Clifford Day ,  Angus Bewick

IPC: G01J3/02 ,  G01J3/44 ,  G01Q20/02 ,  G01Q60/00 ,  H01J37/22 ,  H01J37/256 ,  G01J3/28 ,  H01J37/30

CPC classification number: H01J37/228 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0243 ,  G01J3/44 ,  H01J37/256 ,  H01J2237/2445 ,  H01J2237/2808

Abstract: An electron microscope 10 is adapted to enable spectroscopic analysis of a sample 16. A parabolic mirror 18 has a central aperture 20 through which the electron beam can pass. The mirror 18 focuses laser illumination from a transverse optical path 24 onto the sample, and collects Raman and/or other scattered light, passing it back to an optical system 30. The mirror 18 is retractable (within the vacuum of the electron microscope) by a sliding arm assembly 22.

Abstract translation: 电子显微镜10适于使得能够对样品16进行光谱分析。 抛物面反射镜18具有中心孔20，电子束可以穿过中心孔20。 反射镜18将来自横向光路24的激光照明聚焦到样品上，并收集拉曼和/或其他散射光，将其返回到光学系统30。 镜子18可以通过滑动臂组件22缩回（在电子显微镜的真空中）。