公开(公告)号：US08128871B2

公开(公告)日：2012-03-06

申请号：US11112807

申请日：2005-04-22

Applicant: Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

IPC: G01N33/00

CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

Abstract: In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

Abstract translation: 一方面，诊断测试系统包括壳体，读取器和数据分析器。 壳体包括用于接收测试条的端口。 读取器从暴露于光学检查的检测区域的区域的局部区域获得可分离的光强度测量值，其中每个局部区域的特征在于至少一个小于第一维度的表面尺寸。 数据分析器识别从至少一个测试区域获得的光强度测量结果中的一个，并从所识别的光强测量中计算至少一个参数。 在另一方面，读取器从检测区域的暴露表面区域的多个对应区域中的每一个获得相应的一组光强度测量值，并且数据分析器从至少一个光强度测量集合中计算至少一个参数 。

公开(公告)号：US20120021525A1

公开(公告)日：2012-01-26

申请号：US13031146

申请日：2011-02-18

Applicant: Adrian FEHR ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

Inventor： Adrian FEHR ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

IPC: G01N21/64 ,  H01L27/144 ,  G01J3/50

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

Abstract translation: 提供光学收集和检测系统，用于随着时间的推移从光源阵列测量光信号。 还描述了使用光学器件收集和检测系统的方法。

公开(公告)号：US20120019828A1

公开(公告)日：2012-01-26

申请号：US13031122

申请日：2011-02-18

Applicant: Nathaniel Joseph McCAFFREY ,  Stephen Turner ,  Ravi Saxena ,  Scott Edward Helgesen

Inventor： Nathaniel Joseph McCAFFREY ,  Stephen Turner ,  Ravi Saxena ,  Scott Edward Helgesen

IPC: G01N21/00 ,  H01R12/70 ,  G02B6/02

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  G02B6/1226 ,  Y10T436/143333

Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.

Abstract translation: 用于集成到分析系统中的统一设备结构内的分析组件。 分析组件是可扩展的，并且包括多个分析装置，每个分析装置包括反应池，光学传感器和定位成与反应池和传感器两者光学通信的至少一个光学元件， 电池到传感器。 额外的元件可选地集成到分析组件中。 还公开了形成和操作分析系统的方法。

公开(公告)号：US08043867B2

公开(公告)日：2011-10-25

申请号：US12409871

申请日：2009-03-24

Applicant: Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

IPC: G01N33/53

CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

Abstract: An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

Abstract translation: 测定试片包括流路，样品接收区，标签，包括感兴趣区域的检测区和至少一个位置标记。 所述至少一个位置标记相对于所述感兴趣区域对齐，使得所述至少一个位置标记的位置指示所述感兴趣区域的位置。 诊断测试系统包括从测试条的暴露区域获得光强度测量的读取器，以及数据分析器，其执行以下至少一个：（a）基于至少一个（a）识别从测试区域获得的光强度测量中的一个 测量从所述至少一个参考特征获得的，以及（b）基于从所述至少一个参考特征获得的至少一个测量值生成修改所述读取器的至少一个操作参数的控制信号。

公开(公告)号：US07973921B2

公开(公告)日：2011-07-05

申请号：US12145708

申请日：2008-06-25

Applicant: Shai Silberstein ,  Tsafrir Avni

Inventor： Shai Silberstein ,  Tsafrir Avni

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N21/9503 ,  G01N21/95607 ,  G01N21/95623 ,  G01N2021/8825 ,  G01N2201/067 ,  G01N2201/0675 ,  G01N2201/0697 ,  G01N2201/1241

Abstract: An optical inspection system or tool can be configured to inspect objects using dynamic illumination where one or more characteristics of the illumination is/are adjusted to meet the inspection needs of different areas. For example, the illumination intensity may be increased or decreased as the tool inspects areas of memory and periphery features in a wafer die. In some embodiments, the adjustment can be based on data obtained during a pre-inspection setup sequence in which images taken based on illumination with varying characteristics are evaluated for suitability in the remainder of the inspection process.

Abstract translation: 光学检查系统或工具可以被配置为使用动态照明来检查物体，其中调整照明的一个或多个特征以满足不同区域的检查需要。 例如，当工具检查晶片管芯中的存储器区域和外围特征时，可以增加或减小照明强度。 在一些实施例中，调整可以基于在预检查设置顺序期间获得的数据，其中基于具有变化特性的照明拍摄的图像被评估为在检查过程的其余部分中的适用性。

公开(公告)号：US07800753B1

公开(公告)日：2010-09-21

申请号：US12399743

申请日：2009-03-06

Applicant: William F. Hug ,  Ray D. Reid

Inventor： William F. Hug ,  Ray D. Reid

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/10 ,  G01J3/36 ,  G01J3/44 ,  G01N21/645 ,  G01N27/44721 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/0612 ,  G01N2201/067

Abstract: Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor lasers, incoherent wide bandgap semiconductor light emitting devices, and hollow cathode metal ion lasers to perform non-contact, non-invasive detection of unknown chemical analytes. These deep ultraviolet sources enable dramatic size, weight and power consumption reductions of chemical analysis instruments. Chemical analysis instruments employed in some embodiments include capillary and gel plane electrophoresis, capillary electrochromatography, high performance liquid chromatography, flow cytometry, flow cells for liquids and aerosols, and surface detection instruments. In some embodiments, Raman spectroscopic detection methods and apparatus use ultra-narrow-band angle tuning filters, acousto-optic tuning filters, and temperature tuned filters to enable ultra-miniature analyzers for chemical identification. In some embodiments Raman analysis is conducted simultaneously with native fluorescence spectroscopy to provide high levels of sensitivity and specificity in the same instrument.

Abstract translation: 公开了使用深紫外线（例如在200nm至300nm光谱范围内）的电子束泵浦宽带隙半导体激光器，非相干宽带隙半导体发光器件和空心阴极金属离子激光器的光谱化学分析方法和装置， 接触，未知化学分析物的非侵入性检测。 这些深紫外线源可以显着降低化学分析仪器的体积，重量和功耗。 在一些实施方案中使用的化学分析仪器包括毛细管和凝胶平面电泳，毛细管电色谱，高效液相色谱，流式细胞术，液体和气溶胶流动池以及表面检测仪器。 在一些实施例中，拉曼光谱检测方法和装置使用超窄带角度调谐滤波器，声光调谐滤波器和温度调节滤波器，以使超微型分析仪能够进行化学鉴定。 在一些实施方案中，拉曼分析与天然荧光光谱同时进行，以在同一仪器中提供高水平的灵敏度和特异性。

公开(公告)号：US07728979B2

公开(公告)日：2010-06-01

申请号：US11749142

申请日：2007-05-15

Applicant: Tzyy-Jiann Wang ,  Chih-Wuei Hsieh

Inventor： Tzyy-Jiann Wang ,  Chih-Wuei Hsieh

IPC: G01N21/55

CPC classification number: G01N21/553 ,  G01N2201/067

Abstract: A method and a device for detecting object properties using electro-optically modulated surface plasmon resonance (SPR) based on phase detection is disclosed. In the case of a surface plasmon resonance sensing device according to the present invention, the voltage is applied on the sensing device made of an electro-optic material to modulate the surface plasmon resonance condition by varying the wavevector of the incident lightwave. The relation between the phase of output optical wave and the applied voltage is measured, and the solution concentration or the material property is obtained by using the slope of a regression straight line of this relations. The invention can be used in the experimental arrangements of the attenuated-total-reflection (ATR) structure and the optical waveguide structure, and has advantages of high sensitivity, high stability, small bulk, low equipment cost, etc.

Abstract translation: 公开了一种使用基于相位检测的电光调制表面等离子体共振（SPR）检测物体特性的方法和装置。 在根据本发明的表面等离子体共振感测装置的情况下，电压被施加在由电光材料制成的感测装置上，以通过改变入射光波的波矢来调制表面等离子体共振条件。 测量输出光波相位与施加电压之间的关系，通过使用该关系的回归直线的斜率来获得溶液浓度或材料特性。 本发明可用于衰减全反射（ATR）结构和光波导结构的实验布置，具有灵敏度高，稳定性高，体积小，设备成本低等优点。

公开(公告)号：US20090180926A1

公开(公告)日：2009-07-16

申请号：US12409871

申请日：2009-03-24

Applicant: Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

IPC: G01N31/22

CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

Abstract: An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

公开(公告)号：US20080045820A1

公开(公告)日：2008-02-21

申请号：US11973790

申请日：2007-10-10

Applicant: Mihailo Rebec ,  James Smous ,  Steven Brown ,  Hu-Wei Tan

Inventor： Mihailo Rebec ,  James Smous ,  Steven Brown ,  Hu-Wei Tan

IPC: A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/726 ,  G01N21/274 ,  G01N21/359 ,  G01N2201/067

Abstract: A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.

Abstract translation: 用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。

公开(公告)号：US20070046943A1

公开(公告)日：2007-03-01

申请号：US11210633

申请日：2005-08-24

Applicant: Gregory VanWiggeren ,  Scott Corzine

Inventor： Gregory VanWiggeren ,  Scott Corzine

IPC: G01N21/55

CPC classification number: G01N21/553 ,  G01N2201/067

Abstract: A system and method of using a refractive index sensor to determine a characteristic of a sample. The operation of the system and method allow for determining a change in a bulk index of the sample, and an amount of sample adsorption, using a reflected beam from an interface of the sensor. An embodiment of a system and method further provide for identifying changes in incident angles determine from reflective measurement data of the sensor, in combination with different proportionality constants of the refractive index sensor to determine a characteristic of the sample.

Abstract translation: 一种使用折射率传感器来确定样品特征的系统和方法。 系统和方法的操作允许使用来自传感器的界面的反射光束来确定样品的体积指数的变化和样品吸附的量。 系统和方法的实施例进一步提供用于识别入射角度的变化，其根据传感器的反射测量数据，结合折射率传感器的不同比例常数来确定样本的特性。