公开(公告)号：WO2011084294A1

公开(公告)日：2011-07-14

申请号：PCT/US2010/059053

申请日：2010-12-06

Applicant: BUCYRUS MINING EQUIPMENT, INC. ,  CONNELL, Stuart A.

Inventor： CONNELL, Stuart A.

IPC: E21B7/02 ,  E21B19/00

CPC classification number: F16L3/01 ,  E21C35/046

Abstract: A rock drill system may include a support arrangement including a feed channel, a rock drill assembly movably associated with the feed channel, and a fluid conductor having a first end connected to the rock drill assembly and a second end associated with the support arrangement. The system may further include a tensioning arm pivotally coupled to the support arrangement, wherein the tensioning arm is engageable with the fluid conductor to tension the fluid conductor.

Abstract translation: 凿钻系统可以包括支撑装置，其包括进料通道，与进料通道可移动地相关联的岩石钻机组件，以及具有连接到凿岩机组件的第一端和与支撑装置相关联的第二端的流体导体。 系统还可以包括枢转地联接到支撑装置的张紧臂，其中张紧臂可与流体导体接合以张紧流体导体。

公开(公告)号：WO2011005969A3

公开(公告)日：2011-01-13

申请号：PCT/US2010/041379

申请日：2010-07-08

Applicant: THE GENERAL HOSPITAL CORPORATION ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  RAINES, Douglas E. ,  COTTEN, Joseph, F. ,  FORMAN, Stuart, A. ,  MILLER, Keith, W. ,  HUSAIN, Syed, S. ,  CUNY, Gregory, D.

Inventor： RAINES, Douglas E. ,  FORMAN, Stuart, A. ,  MILLER, Keith, W. ,  HUSAIN, Syed, S. ,  CUNY, Gregory, D.

IPC: C07D207/333 ,  C07D233/64 ,  A61K31/4164 ,  A61P5/38 ,  A61P25/00

Abstract: The invention is directed to compounds according to formula (I): where R 1 is L 1 C(O)OT or L 1 C(O)OL 2 C(O)OT; R 2 is a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, or R 1 ; n is an integer from 0 to 5; each R 3 is independently halogen or R 2 ; R 4 and R 5 are independently H, halogen, CN or CF 3 ; L 1 and L 2 are each independently a bond, a substituted or unsubstituted C 1 -C 10 alkylene, C 2 -C 10 alkenylene, or C 2 -C 10 alkynylene; and T is H, a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

公开(公告)号：WO2009146024A8

公开(公告)日：2010-04-08

申请号：PCT/US2009038872

申请日：2009-03-31

Applicant: GEN HOSPITAL CORP ,  RAINES DOUGLAS E ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED SHAUKAT ,  COTTEN JOSEPH F

Inventor： RAINES DOUGLAS E ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED SHAUKAT ,  COTTEN JOSEPH F

IPC: C07D233/58 ,  A61P23/00 ,  C07D233/56

CPC classification number: C07D233/90 ,  A61K31/4174 ,  A61K45/06

Abstract: The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

Abstract translation: 本发明涉及式（I）化合物：其中R1是L1C（O）OT或L1C（O）OL2C（O）OT; R2是取代或未取代的C1-C10烷基，C2-C10烯基或C2-C10炔基，或R1; n为0〜5的整数， 每个R 3独立地是卤素或R 2; L1和L2各自独立地为键，取代或未取代的C1-C10亚烷基，C2-C10亚烯基或C2-C10亚炔基; 和T是H，取代或未取代的C 1 -C 10烷基，C 2 -C 10烯基或C 2 -C 10炔基，硝基苯酚或环丙基。 本发明还涉及包含根据式（I）的化合物和药学上可接受的载体的药物组合物，以及通过施用这种药物组合物在哺乳动物中提供麻醉的方法。

公开(公告)号：WO2007056588A3

公开(公告)日：2009-04-30

申请号：PCT/US2006043835

申请日：2006-11-09

Applicant: GSI GROUP CORP ,  MITCHELL DONALD K ,  GRIMES DONALD L ,  THORBURN WILLIAM G ,  DODSON STUART A II ,  HINRICHS KEITH M ,  GOLDMAN ANDREW ,  PETERSEN JOEL M ,  RICH CHRISTOPHER C

Inventor： MITCHELL DONALD K ,  GRIMES DONALD L ,  THORBURN WILLIAM G ,  DODSON STUART A II ,  HINRICHS KEITH M ,  GOLDMAN ANDREW ,  PETERSEN JOEL M ,  RICH CHRISTOPHER C

IPC: G01D5/347

CPC classification number: G01D5/34707 ,  G01D5/347 ,  G01D5/366

Abstract: A flexible optical marker is applied to an optical scale substrate to make an optical scale assembly for an optical position encoder. The marker may be a limit marker, index marker, or other type of marker. The marker substrate may be a plastic film such as polyester, having a microstructured pattern on one surface covered with a reflective metal coating, and an adhesive layer for affixing to the optical scale substrate. The marker may be applied with a handle portion that is separated from the marker after the marker is affixed. The marker may be especially useful with a flexible scale substrate such as a metal tape substrate. By affixing the marker to the scale substrate as a separate step of making an encoder scale, various benefits such as reduced inventory, cost, and lead time may be achieved.

Abstract translation: 将柔性光学标记应用于光学尺度基板以制造用于光学位置编码器的光学尺度组件。 标记可以是限制标记，指数标记或其他类型的标记。 标记基板可以是塑料膜，例如聚酯，在一个被反射金属涂层覆盖的表面上具有微结构化图案，以及粘附层，用于固定到光刻基板。 标记物可以在标记物固定之后施加与标记物分离的手柄部分。 该标记可能对于诸如金属带基材之类的柔性标尺基底特别有用。 通过将标记附着到刻度尺基板上，作为制作编码器刻度的单独步骤，可以实现诸如减少库存，成本和提前期的各种益处。

公开(公告)号：WO2009038839A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/066439

申请日：2008-06-10

Applicant: XM SATELLITE RADIO, INC. ,  COX, Stuart, A. ,  MARKO, Paul ,  PATSIOKAS, Stelios

Inventor： COX, Stuart, A. ,  MARKO, Paul ,  PATSIOKAS, Stelios

IPC: G06F15/16

CPC classification number: H04B1/082 ,  H04B1/205

Abstract: A remote application server that operates cooperatively with an embedded radio receiver (52) in a vehicle can include a standalone portable device (12 or 60) having memory (41) for storing and independently presenting audio or data wirelessly received by the embedded receiver and a communication interface (45) in the standalone portable device for receiving audio and data received at the embedded receiver and for transferring audio or data or both to and from a computer network (49) when coupled to the network and for uploading stored audio or data or both to a user interface (57) when coupled to the embedded receiver. The server can include a processor (46) in the standalone portable device for remotely running applications on the standalone portable device that are presented on the user interface coupled to the embedded receiver via a thin client (71) resident in the user interface or embedded receiver.

Abstract translation: 与车辆中的嵌入式无线电接收机（52）协同工作的远程应用服务器可以包括具有用于存储和独立地呈现嵌入式接收机无线接收的音频或数据的存储器（41）的独立便携式设备（12或60）和 通信接口（45），用于接收在嵌入式接收器处接收的音频和数据，并且用于当耦合到网络并且用于上传存储的音频或数据时传送音频或数据或者从计算机网络（49）传送和传输音频或数据，或者 当与嵌入式接收器耦合时，它们都与用户接口（57）连接。 服务器可以包括在独立便携式设备中的处理器（46），用于通过驻留在用户接口或嵌入式接收器中的瘦客户机（71）来远程运行在独立便携式设备上呈现在与嵌入式接收器耦合的用户界面上的应用的应用 。

公开(公告)号：WO2008108825A3

公开(公告)日：2008-12-18

申请号：PCT/US2007021748

申请日：2007-10-10

Applicant: BURNHAM INST MEDICAL RESEARCH ,  LIPTON STUART A ,  SATOH TAKUMI

Inventor： LIPTON STUART A ,  SATOH TAKUMI

IPC: A01N33/02 ,  A61K31/13

CPC classification number: C07C62/32 ,  C07C62/38 ,  C07C69/757 ,  C07C2602/26

Abstract: Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keapl, a negative regulator of the transcription factor Nrf2, and prevent Keapl -mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keapl /Nrf2 complex.

Abstract translation: 神经突起伸展促进前列腺素（NEPPs）和其它电子化合物结合Keapl，转录因子Nrf2的负调节物，并防止Keapl介导的Nrf2的失活，因此，提高Nrf2的易位到神经元细胞的细胞核中。 因此，提供了神经保护组合物和相关方法，其使用这样的神经保护性化合物以及这些化合物的前体药物来引起Nrf2从Keap1 / Nrf2复合体解离。

公开(公告)号：WO2008108813A2

公开(公告)日：2008-09-12

申请号：PCT/US2007/020470

申请日：2007-09-21

Applicant: SOLAR TURBINES INCORPORATED ,  LOCKYER, John, F. ,  GREENWOOD, Stuart, A. ,  DUTTA, Partha, X. ,  GROOCOCK, Ted, E. ,  FOX, Michael, D.

Inventor： LOCKYER, John, F. ,  GREENWOOD, Stuart, A. ,  DUTTA, Partha, X. ,  GROOCOCK, Ted, E. ,  FOX, Michael, D.

CPC classification number: F23R3/04 ,  F23R3/002 ,  F23R2900/03044 ,  Y02T50/675

Abstract: A combustor liner assembly (46) includes a liner assembly (56), including a hot dome (82), a hot wall (78, 80), and an impingement shield (76, 96). The liner assembly further includes a convector assembly (58). The combustor liner assembly further includes an impingement dome assembly (60), including a ring-shaped portion (104) defining a plurality of apertures (106) configured to receive a plurality of fuel injectors, and a face (126). The ring- shaped portion and the face define an annular passage (128), and the face defines a plurality of apertures and a plurality of orifices (130). The convector assembly and the impingement dome assembly are operably coupled to one another, and the plurality of orifices of the face are configured such that the hot dome is exposed to air flowing in the annular passage of the impingement dome assembly. The combustor liner assembly is configured to provide flow communication between the annular passage of the impingement dome assembly and the plurality of fuel injectors.

Abstract translation: 燃烧器衬套组件（46）包括衬套组件（56），其包括热穹顶（82），热壁（78,80）和冲击屏蔽件（76,96）。 衬套组件还包括对流式组件（58）。 燃烧器衬套组件还包括冲击圆顶组件（60），其包括限定被配置为容纳多个燃料喷射器的多个孔（106）的环形部分（104）和面部（126）。 所述环形部分和所述面限定环形通道（128），并且所述面限定多个孔和多个孔（130）。 对流器组件和冲击圆顶组件可操作地彼此联接，并且面的多个孔被构造成使得热的圆顶暴露于在冲击圆顶组件的环形通道中流动的空气。 燃烧器衬套组件构造成提供冲击圆顶组件的环形通道与多个燃料喷射器之间的流动连通。

公开(公告)号：WO2008021489A3

公开(公告)日：2008-05-29

申请号：PCT/US2007018245

申请日：2007-08-17

Applicant: ATI TECHNOLOGIES INC ,  TAYLOR STUART A ,  MA VICTOR ,  PATEL BHARAT

Inventor： TAYLOR STUART A ,  MA VICTOR ,  PATEL BHARAT

IPC: G06F17/50 ,  H01L23/52

CPC classification number: G06F17/5045 ,  G06F2217/84

Abstract: An integrated circuit (IC) chip having repeaters for propagating signals along relatively long wires that extend between and among lower-level physical blocks of the IC chip, wherein the repeaters are implemented as clocked flip-flops (or "repeater flops"). A method for automatically inserting and allocating such repeater flops during the logical and physical design of the IC chip is also provided.

Abstract translation: 一种集成电路（IC）芯片，其具有用于沿着在IC芯片的下级物理块之间延伸的较长导线传播信号的中继器，其中中继器被实现为时钟触发器（或“中继器”）。 还提供了在IC芯片的逻辑和物理设计期间自动插入和分配这种中继器的方法。

公开(公告)号：WO2008021489A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/018245

申请日：2007-08-17

Applicant: ATI TECHNOLOGIES INC. ,  TAYLOR, Stuart, A. ,  MA, Victor ,  PATEL, Bharat

Inventor： TAYLOR, Stuart, A. ,  MA, Victor ,  PATEL, Bharat

IPC: G06F17/50 ,  H01L23/52

CPC classification number: G06F17/5045 ,  G06F2217/84

Abstract: An integrated circuit (IC) chip having repeaters for propagating signals along relatively long wires that extend between and among lower-level physical blocks of the IC chip, wherein the repeaters are implemented as clocked flip-flops (or "repeater flops"). A method for automatically inserting and allocating such repeater flops during the logical and physical design of the IC chip is also provided.

Abstract translation: 具有转发器的集成电路（IC）芯片用于沿着在IC芯片的较低级物理块之间延伸的较长导线传播信号，其中转发器被实现为时钟触发器（ 或“中继器触发器”）。 还提供了在IC芯片的逻辑和物理设计期间自动插入和分配这种中继器触发器的方法。

公开(公告)号：WO2007146224A3

公开(公告)日：2008-02-14

申请号：PCT/US2007013683

申请日：2007-06-07

Applicant: MERCK & CO INC ,  GOTTESDIENER KEITH M ,  GREEN STUART A ,  MACINTYRE EUAN

Inventor： GOTTESDIENER KEITH M ,  GREEN STUART A ,  MACINTYRE EUAN

IPC: A01N33/02 ,  A61K31/135

CPC classification number: A61K31/4015 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention concerns compositions for the treatment of urinary frequency, urinary urgency and urinary incontinence comprising a selected antagonist of the NK-1 receptor or a pharmaceutically acceptable salt thereof and an anti-muscarinic agent or a pharmaceutically acceptable salt thereof. This invention concerns combination therapy for urinary frequency, urinary urgency and urinary incontinence wherein one of the active agents is a selected antagonist of the NK-1 receptor or a pharmaceutically acceptable salt thereof and another is an anti-muscarinic agent or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及用于治疗尿频，尿急和尿失禁的组合物，其包含选择的NK-1受体拮抗剂或其药学上可接受的盐和抗毒蕈碱剂或其药学上可接受的盐。 本发明涉及尿频，尿急和尿失禁的联合治疗，其中一种活性剂是选择的NK-1受体拮抗剂或其药学上可接受的盐，另一种是抗毒蕈碱剂或其药学上可接受的盐 。